Clinical Translation Start Trials - ClinicStarT

In the framework of promoting translational research, the IZKF Münster has developed innovative concepts to close the gap between funding basic research (e.g. mouse studies) and patient-centred research.
Since 2019, the "ClinicStarT" programme funds innovative concepts and science-driven ideas for clinical studies that will later be transferred to external funding programmes. These include clinical observation studies, early clinical feasibility studies (proof of concept) and first pilot studies on patients, which should bring knowledge from basic research and animal experiments into clinical trials.

Funded clinical trials

  • CST/007/25 - Impact of smartwatch-guided walking exercise on post-stroke fatigue and cognitive impairment with a special focus on immunological and structural correlates
    Principal Investigators: Antje Schmidt-Pogoda, Frederike Anne Riethues
    Funding period: 01/2025 - 12/2026
  • CST/005/25 - Uncovering occult invasive breast cancer in DCIS with 68Ga-FAPI breast PET/MRI for de-escalating axillary surgery
    Principal Investigators: Philipp Backhaus, Matthias Burg, Michael Schäfers
    Funding period: 01/2025 - 12/2026
  • CST/006/24 - A Randomized Controlled Study Investigating Standard Dose Continuous Renal Replacement Therapy (CRRT) Versus Low-Dose CRRT - Ketzerei Trial
    Principal Investigators: Alexander Zarbock, Noelia Alonso Gonzalez (BBB Approach)
    Funding period: 01/2024 - 12/2025
  • CST/003/22 - Effects of a combined supplementation of conjugated linoleic acid (CLA) and probiotics (Vivomixx®/VSL#3) as add-on to a first-line immunotherapy in relapsing-remitting Multiple Sclerosis
    Principal Investigators: Luisa Klotz, Thomas Vogl (BBB Approach)
    Funding period: 04/2023 - 03/2025

  • completed Clinical Translation Start Trials - ClinicStarT

    • CST/004/22 - Finding a patient individualized strategy for the initiation of renal re-placement therapy (RRT) in critically ill patients with acute kidney injury (AKI) – an observational trial
      Principal Investigators: Melanie Meersch, Johannes Roth (BBB Approach)
      Funding period: 01/2022 - 12/2023
    • CST/001/19 - Biomarker-guided implementation of glutamine to reduce the occurrence of AKI after cardiac surgery (Acronym: Glutamine to reduce cardiac surgery-associated AKI (Glacé-Trial))
      Principal investigator: Alexander Zarbock
      Funding period: 09/2019 - 08/2021
    • CST/002/19 - Phase II trial to assess the efficacy of low dose involved site radiation therapy (ISRT) with 20 Gy in localized indolent gastric or duodenal lymphoma
      Principal investigators: Gabriele Reinartz, Burkhard Greve, Hans Theodor Eich
      Funding period: 09/2019 - 02/2022