Project: FG/007/25
Duration: 09.2025 - 08.2029

Obesity is one of the greatest health challenges of our time and increases the risk of heart disease, diabetes, and liver damage. A major reason for these harmful effects is that obesity causes chronic, low-grade inflammation, which gradually damages tissues and organs. The aim of current research is to better understand how the immune system regulates this inflammation. In particular, a group of molecules known as inhibitory receptors is in the focus, as they play a key role in maintaining immune balance. By deciphering the molecular mechanisms of these receptors and their function in controlling inflammatory processes, the team led by Dr. Mariano Malamud Guillan (Institute of Experimental Pathology, ZMBE) hopes to identify new strategies to reduce harmful immune responses and to protect people from the health problems associated with obesity and related metabolic diseases.