Einfluss von Alter und Genetik auf die Vaterschaft | by Dr. Marcus Mau
[translated from German into English]
Influence of age and genetics on fatherhood
-from the article-
...The sperm of affected men appear normal and motile. However, if the function of an ion channel (CatSper) is disturbed, the sperm cannot penetrate the egg coat and thus, cannot fertilize the egg.
Couples in which the man has this gene mutation can only conceive by means of assisted fertilization through intracytoplasmic sperm injection (ICSI).
Testing for this particular gene alteration saves the couple many futile attempts at fertility treatment. The CatSper test, a "rapid sperm test" is available that detects the absence of the ion channel during a routine examination...