During infections, leukocytes are rapidly recruited into inflamed tissues in a coordinated sequence of events that is needed for an adequate immune response. STIM calcium sensing proteins and ORAI-calcium channels are involved in store-operated calcium entry (SOCE) regulation in immune cells. Preliminary data indicate that STIM1 and ORAI1 are required for chemokine-induced integrin activation and neutrophil arrest. Here, we will address the following questions: 1) What is the interconnection between calcium-concentration regulating proteins and GTPases in neutrophils? 2) Which role do STIM and ORAI play during the regulation of integrin activity and 3) for the different steps of neutrophil recruitment?
Research area: Leukocyte biology
Prof. Dr. med. Alexander Zarbock
Funding period: July 2012 - June 2024