
© I. Kuzmanov
Our project deals with the interactions of invading immune cells with the cellular components of the blood-brain-barrier in the context of neuroinflammation. We will study interactions between human immune cells and iPS cell-derived brain endothelial cells from patients suffering from distinct neuroinflammatory diseases, and study the consequences of in vivo transfer of human immune cells in a humanized mouse model. Furthermore, we will elucidate the role of pericyte loss or dysfunction for blood-brain-barrier integrity, chronic inflammation and demyelination.
Research area: Neuroimmunology
Prof. Dr. med. Heinz Wiendl
Prof. Dr. med. Luisa Klotz (since 07/2016)
Funding period: July 2012 - June 2024
Original articles
Reviews