This proposal consists of two parts which aim at different endothelial barriers. The first part will focus on leukocyte extravasation. In detail, we will analyze mechanims that control chemotaxis and intra- and extravasacular crawling of leukocytes. In the second part, we will analyze the endothelial barrier of a specialized vessel in the eye, the Schlemm’s canal. We will investigate how the phosphatase VE-PTP regulates the uptake of aqueous humor from the eye, a task which is essential to prevent a build up of intraocular pressure and the development of glaucoma.
Research area: Endothelial cell biology
Prof. Dr. rer. nat. Dietmar Vestweber
Funding period: July 2012 - June 2024