Publikationen 2021-…

1: Rajan R, Schepmann D, Steigerwald R, Schreiber JA, El-Awaad E, Jose J, Seebohm G, Wünsch B. [2.2]Paracyclophane-Based TCN-201 Analogs as GluN2A-Selective NMDA Receptor Antagonists. ChemMedChem. 2021 Jul 15.

2: Schreiber JA, Seebohm G. Cardiac K+ Channels and Channelopathies. Handb Exp Pharmacol. 2021 Jul 11.

3: Jeworutzki E, Tüttelmann F, Rothenberg I, Pusch M, Schreiber JA, Kliesch S, Wünsch B, Strutz-Seebohm N, Seebohm G. Can Unlikely Neanderthal Chloride Channel CLC-2 Gene Variants Provide Insights in Modern Human Infertility? Cell Physiol Biochem. 2021 Jun 19;55(3):301-310.

4: Seebohm G, Schreiber JA. Beyond Hot and Spicy: TRPV Channels and their Pharmacological Modulation. Cell Physiol Biochem. 2021 May 28;55(S3):108-130.

5: Ritter N, Korff M, Markus A, Schepmann D, Seebohm G, Schreiber JA, Wünsch B. Deconstruction - Reconstruction: Analysis of the Crucial Structural Elements of GluN2B-Selective, Negative Allosteric NMDA Receptor Modulators with 3-Benzazepine Scaffold. Cell Physiol Biochem. 2021 Mar 3;55(S3):1-13.

6: Bechthold E, Schreiber JA, Lehmkuhl K, Frehland B, Schepmann D, Bernal FA, Daniliuc C, Álvarez I, Garcia CV, Schmidt TJ, Seebohm G, Wünsch B. Ifenprodil Stereoisomers: Synthesis, Absolute Configuration, and Correlation with Biological Activity. J Med Chem. 2021 Jan 28;64(2):1170-1179.

7: Fischer B, Dittmann S, Brodehl A, Unger A, Stallmeyer B, Paul M, Seebohm G, Kayser A, Peischard S, Linke WA, Milting H, Schulze-Bahr E. Functional characterization of novel alpha-helical rod domain desmin (DES) pathogenic variants associated with dilated cardiomyopathy, atrioventricular block and a risk for sudden cardiac death. Int J Cardiol. 2021 Apr 15;329:167-174.

8: Rajan R, Schepmann D, Schreiber JA, Seebohm G, Wünsch B. Synthesis of GluN2A-selective NMDA receptor antagonists with an electron-rich aromatic B-ring. Eur J Med Chem. 2021 Jan 1;209:112939.

 

Publikationen 2016-2020 (38)

1: Renner H, Grabos M1, Becker KJ, Kagermeier TE, Wu J, Otto M, Peischard S, Zeuschner D, Tsytsyura Y, Disse P, Klingauf J, Leidel SA, Seebohm G, Schöler HR, Bruder JM. A fully automated high throughput workflow for 3D-based drug screening in human midbrain organoids. Elife. 2020 Nov 3;9:e52904.

2: Peischard S, Ho HT, Piccini I, Strutz-Seebohm N, Röpke A, Liashkovich I, Gosain H, Rieger B, Klingel K, Eggers B, Marcus K, Linke WA, Müller FU, Ludwig S, Greber B, Busch K, Seebohm G. The first versatile human iPSC-based model of ectopic virus induction allows new insights in RNA-virus disease. Sci Rep. 2020 Oct 8;10(1):16804.

3: Mecate-Zambrano A, Sukumar S, Seebohm G, Ciminski K, Schreiber A, Anhlan D, Greune L, Wixler L, Grothe S, Stein NC, Schmidt MA, Langer K, Schwemmle M, Shi T, Ludwig S, Boergeling Y. Discrete spatio-temporal regulation of tyrosine phosphorylation directs influenza A virus M1 protein towards its function in virion assembly. PLoS Pathog. 2020 Aug 31;16(8):e1008775.

4: Patrick Hansmann P, Brückner A, Kiontke S, Seebohm G, Vikkula M, Jansen FE, Nellist M, Oeckinghaus A, Kümmel D. Structure of the TSC2 GAP domain: mechanistic insight into catalysis and pathogenic mutations, Structure. 2020 Aug 4;28(8):933-942.e4.

5: Lübke M, Schreiber JA, Le Quoc T, Körber F, Müller J, Sivanathan S, Matschke V, Schubert J, Strutz-Seebohm N, Seebohm G*, Scherkenbeck J*. Rottlerin: Structure Modifications and KCNQ1/KCNE1 Ion Channel Activity. ChemMedChem. 2020 Jun 17;15(12):1078-1088.

6: Bollmann E, Schreiber JA, Ritter N, Peischard S, Ho HT, Wünsch B, Strünker T, Meuth S, Budde T, Strutz-Seebohm N, Seebohm G. 4,4'-Diisothiocyanato-2,2'-Stilbenedisulfonic Acid (DIDS) Modulates the Activity of KCNQ1/KCNE1 Channels by an Interaction with the Central Pore Region. Cell Physiol Biochem. 2020 Apr 8;54(2):321-332.

7: Temme L, Bechthold E, Schreiber JA, Gawaskar S, Schepmann D, Robaa D, Sippl W, Seebohm G, Wünsch B. Negative allosteric modulators of the GluN2B NMDA receptor with phenylethylamine structure embedded in ring-expanded and ring-contracted scaffolds. Eur J Med Chem. 2020;190:112138.

8: Hou P, Kang PW, Kongmeneck AD, Yang ND, Liu Y, Shi J, Xu X, White KM, Zaydman MA, Kasimova MA, Seebohm G, Zhong L, Zou X, Tarek M, Cui J. Two-stage electro-mechanical coupling of a K(V) channel in voltage-dependent activation. Nat Commun. 2020;11(1):676.

9: Schreiber JA, Schepmann D, Frehland B, Thum S, Datunashvili M, Budde T, Hollmann M, Strutz-Seebohm N, Wünsch B, Seebohm G. A common mechanism allows selective targeting of GluN2B subunit-containing N-methyl-D-aspartate receptors. Commun Biol. 2019;2:420.

10: Frank D, Yusuf Rangrez A, Friedrich C, Dittmann S, Stallmeyer B, Yadav P, Bernt A, Schulze-Bahr E, Borlepawar A, Zimmermann WH, Peischard S, Seebohm G, Linke WA, Baba HA, Krüger M, Unger A, Usinger P, Frey N, Schulze-Bahr E. Cardiac α-Actin (ACTC1) Gene Mutation Causes Atrial-Septal Defects Associated With Late-Onset Dilated Cardiomyopathy. Circ Genom Precis Med. 2019;12(8):e002491.

11: Peischard S, Ho HT, Theiss C, Strutz-Seebohm N, Seebohm G. A Kidnapping Story: How Coxsackievirus B3 and Its Host Cell Interact. Cell Physiol Biochem. 2019;53(1):121-140.

12: Amedonu E, Brenker C, Barman S, Schreiber JA, Becker S, Peischard S, Strutz-Seebohm N, Strippel C, Dik A, Hartung HP, Budde T, Wiendl H, Strünker T, Wünsch B, Goebels N, Meuth SG, Seebohm G, Melzer N. An Assay to Determine Mechanisms of Rapid Autoantibody-Induced Neurotransmitter Receptor Endocytosis and Vesicular Trafficking in Autoimmune Encephalitis. Front Neurol. 2019 Mar 1;10:178.

13: Kuß J, Stallmeyer B, Goldstein M, Rinné S, Pees C, Zumhagen S, Seebohm G, Decher N, Pott L, Kienitz MC, Schulze-Bahr E. Familial Sinus Node Disease Caused by a Gain of GIRK (G-Protein Activated Inwardly Rectifying K(+) Channel) Channel Function. Circ Genom Precis Med. 2019 Jan;12(1):e002238.

14: Schreiber JA, Müller SL, Westphälinger SE, Schepmann D, Strutz-Seebohm N, Seebohm G*, Wünsch B*. Systematic variation of the benzoylhydrazine moiety of the GluN2A selective NMDA receptor antagonist TCN-201. European Journal of Medicinal Chemistry 158 (2018) 259e269.

15: Möller M, Silbernagel N, Wrobel E, Stallmayer B, Amedonu E, Rinné S, Peischard S, Meuth SG, Wünsch B, Strutz-Seebohm N, Decher N, Schulze-Bahr E, Seebohm G. In Vitro Analyses of Novel HCN4 Gene Mutations. Cell Physiol Biochem. 2018 Sep 7;49(3):1197-1207.

16: Daane JM, Lanni J, Rothenberg I, Seebohm G, Higdon CW, Johnson SL, Harris MP. Bioelectric-calcineurin signaling module regulates allometric growth and size of the zebrafish fin. Sci Rep. 2018 Jul 10;8(1):10391.

17: Börgel F, Szermerski M, Schreiber JA, Temme L, Strutz-Seebohm N, Lehmkuhl K, Schepmann D, Ametamey SM, Seebohm G, Schmidt TJ, Wünsch B. Synthesis and Pharmacological Evaluation of Enantiomerically Pure GluN2B Selective NMDA Receptor Antagonists. ChemMedChem. 2018 May 27.

18: Pfeiffer MJ, Quaranta R, Piccini I, Fell J, Rao J, Röpke A, Seebohm G, Greber B. Cardiogenic programming of human pluripotent stem cells by dose-controlled activation of EOMES. Nat Commun. 2018 Jan 30;9(1):440.

19: Rinné S, Kiper AK, Schmidt C, Ortiz-Bonnin B, Zwiener S, Seebohm G, Decher N. Stress-Kinase Regulation of TASK-1 and TASK-3. Cell Physiol Biochem. 2017;44(3):1024-1037.

20: Malviya M, Barman S, Golombeck KS, Planagumà J, Mannara F, Strutz-Seebohm N, Wrzos C, Demir F, Baksmeier C, Steckel J, Falk KK, Gross CC, Kovac S, Bönte K, Johnen A, Wandinger KP, Martín-García E, Becker AJ, Elger CE, Klöcker N, Wiendl H, Meuth SG, Hartung HP, Seebohm G, Leypoldt F, Maldonado R, Stadelmann C, Dalmau J, Melzer N, Goebels N. NMDAR encephalitis: passive transfer from man to mouse by a recombinant antibody. Ann Clin Transl Neurol. 2017 Oct 3;4(11):768-783.

21: Piccini I, Fehrmann E, Frank S, Müller FU, Greber B, Seebohm G. Adrenergic Stress Protection of Human iPS Cell-Derived Cardiomyocytes by Fast K(v)7.1 Recycling. Front Physiol. 2017 Sep 14;8:705. doi: 10.3389/fphys.2017.00705.

22: Zumhagen S, Vrachimis A, Stegger L, Kies P, Wenning C, Ernsting M, Müller J, Seebohm G, Paul M, Schäfers K, Stallmeyer B, Schäfers M, Schulze-Bahr E. Impact of presynaptic sympathetic imbalance in long-QT syndrome by positron emission tomography. Heart. 2018 Feb;104(4):332-339. doi: 10.1136/heartjnl-2017-311667.

23: Gawaskar S, Temme L, Schreiber JA, Schepmann D, Bonifazi A, Robaa D, Sippl W, Strutz-Seebohm N, Seebohm G, Wünsch B. Design, Synthesis, Pharmacological Evaluation and Docking Studies of GluN2B-Selective NMDA Receptor Antagonists with a Benzo[7]annulen-7-amine Scaffold. ChemMedChem. 2017 Aug 8;12(15):1212-1222.

24: Marczenke M, Piccini I, Mengarelli I, Fell J, Röpke A, Seebohm G, Verkerk AO, Greber B. Cardiac Subtype-Specific Modeling of K(v)1.5 Ion Channel Deficiency Using Human Pluripotent Stem Cells. Front Physiol. 2017 Jul 6;8:469.

25: Dey S, Temme L, Schreiber JA, Schepmann D, Frehland B, Lehmkuhl K, Strutz-Seebohm N, Seebohm G, Wünsch B. Deconstruction - reconstruction approach to analyze the essential structural elements of tetrahydro-3-benzazepine-based antagonists of GluN2B subunit containing NMDA receptors. Eur J Med Chem. 2017 Sep 29;138:552-564.

26: Marczenke M, Fell J, Piccini I, Röpke A, Seebohm G, Greber B. Generation and cardiac subtype-specific differentiation of PITX2-deficient human iPS cell lines for exploring familial atrial fibrillation. Stem Cell Res. 2017 May;21:26-28.

27: Kaese S, Larbig R, Rohrbeck M, Frommeyer G, Dechering D, Olligs J, Schönhofer-Merl S, Wessely R, Klingel K, Seebohm G, Eckardt L. Electrophysiological alterations in a murine model of chronic coxsackievirus B3 myocarditis. PLoS One. 2017 Jun 23;12(6):e0180029.

28: Stallmeyer B, Dittmann S, Seebohm G, Müller J, Schulze-Bahr E. Molecular genetic diagnostics for ventricular arrhythmias and sudden cardiac death syndromes. Herz. 2017 Aug;42(5):476-484.

29: Peischard S, Piccini I, Strutz-Seebohm N, Greber B, Seebohm G. From iPSC towards cardiac tissue-a road under construction. Pflugers Arch. 2017 Oct;469(10):1233-1243.

30: Rothenberg I, Piccini I, Wrobel E, Stallmeyer B, Müller J, Greber B, Strutz-Seebohm N, Schulze-Bahr E, Schmitt N, Seebohm G. Structural interplay of K(V)7.1 and KCNE1 is essential for normal repolarization and is compromised in short QT syndrome 2 (K(V)7.1-A287T). HeartRhythm Case Rep. 2016 Sep 12;2(6):521-529.

31: Larbig R, Reda S, Paar V, Trost A, Leitner J, Weichselbaumer S, Motloch KA, Wernly B, Arrer A, Strauss B, Lichtenauer M, Reitsamer HA, Eckardt L, Seebohm G, Hoppe UC, Motloch LJ. Through modulation of cardiac Ca(2+) handling, UCP2 affects cardiac electrophysiology and influences the susceptibility for Ca(2+) -mediated arrhythmias. Exp Physiol. 2017 Jun 1;102(6):650-662.

32: Müller SL, Schreiber JA, Schepmann D, Strutz-Seebohm N, Seebohm G, Wünsch B. Systematic variation of the benzenesulfonamide part of the GluN2A selective NMDA receptor antagonist TCN-201. Eur J Med Chem. 2017 Mar 31;129:124-134.

33: Stallmeyer B, Kuß J, Kotthoff S, Zumhagen S, Vowinkel K, Rinné S, Matschke LA, Friedrich C, Schulze-Bahr E, Rust S, Seebohm G, Decher N, Schulze-Bahr E. A Mutation in the G-Protein Gene GNB2 Causes Familial Sinus Node and Atrioventricular Conduction Dysfunction. Circ Res. 2017 May 12;120(10):e33-e44.

34: Fernández-Orth J, Ehling P, Ruck T, Pankratz S, Hofmann MS, Landgraf P, Dieterich DC, Smalla KH, Kähne T, Seebohm G, Budde T, Wiendl H, Bittner S, Meuth SG. 14-3-3 Proteins regulate K(2P) 5.1 surface expression on T lymphocytes. Traffic. 2017 Jan;18(1):29-43.

35: Wrobel E, Rothenberg I, Krisp C, Hundt F, Fraenzel B, Eckey K, Linders JT, Gallacher DJ, Towart R, Pott L, Pusch M, Yang T, Roden DM, Kurata HT, Schulze-Bahr E, Strutz-Seebohm N, Wolters D, Seebohm G. KCNE1 induces fenestration in the Kv7.1/KCNE1 channel complex that allows for highly specific pharmacological targeting. Nat Commun. 2016 Oct 12;7:12795.

36: Piccini I, Araúzo-Bravo M, Seebohm G, Greber B. Functional high-resolution time-course expression analysis of human embryonic stem cells undergoing cardiac induction. Genom Data. 2016 Sep 28;10:71-74.

37: Nieding K, Matschke V, Meuth SG, Lang F, Seebohm G, Strutz-Seebohm N. Tau Tubulin Kinase TTBK2 Sensitivity of Glutamate Receptor GluK2. Cell Physiol Biochem. 2016;39(4):1444-52.

38: Rao J, Pfeiffer MJ, Frank S, Adachi K, Piccini I, Quaranta R, Araúzo-Bravo M, Schwarz J, Schade D, Leidel S, Schöler HR, Seebohm G, Greber B. Stepwise Clearance of Repressive Roadblocks Drives Cardiac Induction in Human ESCs. Cell Stem Cell. 2016 Apr 7;18(4):554-6.

Publikationen 2011-2015 (42)

1: Rao J, Pfeiffer MJ, Frank S, Adachi K, Piccini I, Quaranta R, Araúzo-Bravo M, Schwarz J, Schade D, Leidel S, Schöler HR, Seebohm G, Greber B. Stepwise Clearance of Repressive Roadblocks Drives Cardiac Induction in Human ESCs. Cell Stem Cell. 2015. pii: S1934-5909(15)00517-2.

2: Tülümen E, Schulze-Bahr E, Zumhagen S, Stallmeyer B, Seebohm G, Beckmann BM, Kääb S, Rudic B, Liebe V, Wolpert C, Herrera-Siklody C, Veltmann C, Schimpf R, Borggrefe M. Early repolarization pattern: a marker of increased risk in patients with catecholaminergic polymorphic ventricular tachycardia. Europace. 2015. pii: euv357.

3: Matschke V, Theiss C, Hollmann M, Schulze-Bahr E, Lang F, Seebohm G, Strutz-Seebohm N. NDRG2 phosphorylation provides negative feedback for SGK1-dependent regulation of a kainate receptor in astrocytes. Front Cell Neurosci. 2015 Oct 6;9:387. doi: 10.3389/fncel.2015.00387. eCollection 2015.

4: Piccini I, Rao J, Seebohm G, Greber B. Human pluripotent stem cell-derived cardiomyocytes: Genome-wide expression profiling of long-term in vitro maturation in comparison to human heart tissue. Genom Data. 2015;4:69-72.

5: Kim RY, Yau MC, Galpin JD, Seebohm G, Ahern CA, Pless SA, Kurata HT. Atomic basis for therapeutic activation of neuronal potassium channels. Nat Commun. 2015;6:8116.

6: Seebohm G, Piccini I, Strutz-Seebohm N. Paving the Way to Understand Autoantibody-Mediated Epilepsy on the Molecular Level. Front Neurol. 2015;6:149.

7: Kohl B, Rothenberg I, Ali SA, Alam M, Seebohm G, Kalbacher H, Voelter W, Stoll R. Solid phase synthesis, NMR structure determination of α-KTx3.8, its in silico docking to Kv1.x potassium channels, and electrophysiological analysis provide insights into toxin-channel selectivity. Toxicon. 2015;101:70-8.

8: Greber B, Verkerk AO, Seebohm G, Mummery CL, Bellin M. Reply to Christ et al.: LQT1 and JLNS phenotypes in hiPSC-derived cardiomyocytes are due to KCNQ1 mutations. Proc Natl Acad Sci U S A. 2015;112(16):E1969.

9: Zhang M, Schulte JS, Heinick A, Piccini I, Rao J, Quaranta R, Zeuschner D, Malan D, Kim KP, Röpke A, Sasse P, Araúzo-Bravo M, Seebohm G, Schöler H, Fabritz L, Kirchhof P, Müller FU, Greber B. Universal Cardiac Induction of Human Pluripotent Stem Cells in 2D and 3D formats - Implications for In-Vitro Maturation. Stem Cells. 2015.

10: Wemhöner K, Friedrich C, Stallmeyer B, Coffey AJ, Grace A, Zumhagen S, Seebohm G, Ortiz-Bonnin B, Rinné S, Sachse FB, Schulze-Bahr E, Decher N. Gain-of-function mutations in the calcium channel CACNA1C (Cav1.2) cause non-syndromic long-QT but not Timothy syndrome. J Mol Cell Cardiol. 2015;80C:186-195.

11: Kiper AK, Rinné S, Rolfes C, Ramírez D, Seebohm G, Netter MF, González W, Decher N. Kv1.5 blockers preferentially inhibit TASK-1 channels: TASK-1 as a target against atrial fibrillation and obstructive sleep apnea? Pflugers Arch. 2014 .

12: Strutz-Seebohm N, Wrobel E, Schulze-Bahr E, Seebohm G. Klotho: a new trafficking modifier of Kv7.1/KCNE1 channels. Channels (Austin). 2014;8(4):285.

13: Zhang M, D'Aniello C, Verkerk AO, Wrobel E, Frank S, Ward-van Oostwaard D, Piccini I, Freund C, Rao J, Seebohm G, Atsma DE, Schulze-Bahr E, Mummery CL, Greber B, Bellin M. Recessive cardiac phenotypes in induced pluripotent stem cell models of Jervell and Lange-Nielsen syndrome: disease mechanisms and pharmacological rescue. Proc Natl Acad Sci U S A. 2014;111(50):E5383-92.

14: Eckey K, Wrobel E, Seebohm G, Pott L, Schmitt N, Strutz-Seebohm N. Novel Kv7.1-phosphatidylinositol 4,5-bisphosphate (PIP2) interaction sites uncovered by charge neutralization scanning. J Biol Chem. 2014. PMID: 24947509.

15: Perathoner S, Daane JM, Henrion U, Seebohm G, Higdon CW, Johnson SL, Nüsslein-Volhard C, Harris MP. Bioelectric signaling regulates size in zebrafish fins. PLoS Genet. 2014;10(1):e1004080.

16: Seebohm G, Wrobel E, Pusch M, Dicks M, Terhag J, Matschke V, Rothenberg I, Ursu ON, Hertel F, Pott L, Lang F, Schulze-Bahr E, Hollmann M, Stoll R, Strutz-Seebohm N. Structural basis of PI(4,5)P(2)-dependent regulation of GluA1 by phosphatidylinositol-5-phosphate 4-kinase, type II, alpha (PIP5K2A). Pflugers Arch. 2014. PMID: 24389605.

17: Liang B, Soka M, Christensen AH, Olesen MS, Larsen AP, Knop FK, Wang F, Nielsen JB, Andersen MN, Humphreys D, Mann SA, Huttner IG, Vandenberg JI, Svendsen JH, Haunsø S, Preiss T, Seebohm G, Olesen SP, Schmitt N, Fatkin D. Genetic variation in the two-pore domain potassium channel, TASK-1, may contribute to an atrial substrate for arrhythmogenesis. J Mol Cell Cardiol. 2014; 67:69-76.

18: Seebohm G. A complex partnership: KCNQ1 and KCNE1. Biophys J. 2013;105(11):2437-8.

19: Zumhagen S, Strutz-Seebohm N, Seebohm G, Schulze-Bahr E. Pharmacological targeting in inherited arrhythmia syndromes. Curr Med Chem. 2014;21(11):1308-19.

20: Hobiger K, Utesch T, Mroginski MA, Seebohm G, Friedrich T. The Linker Pivot in Ci-VSP: The Key to Unlock Catalysis. PLoS One. 2013;8(7):e70272.

21: Strutz-Seebohm N, Henrion U, Schmitt N, Schulze-Bahr E, Seebohm G. A common structural component for β-subunit mediated modulation of slow inactivation in different KV channels. Cell Physiol Biochem. 2013;31(6):968-80.

2: Steinke K, Sachse F, Ettischer N, Strutz-Seebohm N, Henrion U, Rohrbeck M, Klosowski R, Wolters D, Brunner S, Franz WM, Pott L, Munoz C, Kandolf R, Schulze-Bahr E, Lang F, Klingel K, Seebohm G. Coxsackievirus B3 modulates cardiac ion channels. FASEB J. 2013. 27(10):4108-21.

23: Tapken D, Anschütz U, Liu LH, Huelsken T, Seebohm G, Becker D, Hollmann M. A plant homolog of animal glutamate receptors is an ion channel gated by multiple hydrophobic amino acids. Sci Signal. 2013 6(279):ra47.

24: Munoz C, Pakladok T, Almilaji A, Elvira B, Seebohm G, Voelkl J, Föller M, Shumilina E, Lang F. Klotho sensitivity of the hERG channel. FEBS Lett. 2013587(11):1663-8.

25: Vandenberg LN, Morrie RD, Seebohm G, Lemire JM, Levin M. Rab GTPases are required for early orientation of the left-right axis in Xenopus. Mech Dev. 2013.

26: Füll Y, Seebohm G, Lerche H, Maljevic S. A conserved threonine in the S1-S2 loop of K(V)7.2 and K (V)7.3 channels regulates voltage-dependent activation. Pflugers Arch. 2012.

27: Bogatikov E, Munoz C, Pakladok T, Alesutan I, Shojaiefard M, Seebohm G, Föller M, Palmada M, Böhmer C, Bröer S, Lang F. Up-Regulation of Amino Acid Transporter SLC6A19 Activity and Surface Protein Abundance by PKB/Akt and PIKfyve. Cell Physiol Biochem. 2012;30(6):1538-46.

28: Zumhagen S, Stallmeyer B, Friedrich C, Eckardt L, Seebohm G, Schulze-Bahr E. Inherited long QT syndrome: clinical manifestation, genetic diagnostics, and therapy. Herzschrittmacherther Elektrophysiol. 2012;23(3):211-9.

29: Munoz C, Saxena A, Pakladok T, Bogatikov E, Wilmes J, Seebohm G, Föller M, Lang F. Stimulation of HERG channel activity by β-catenin. PLoS One. 2012;7(8):e43353.

30: Wrobel E, Tapken D, Seebohm G. The KCNE Tango - How KCNE1 Interacts with Kv7.1. Front Pharmacol. 2012;3:142.

31: Föller M, Jaumann M, Dettling J, Saxena A, Pakladok T, Munoz C, Ruth P, Sopjani M, Seebohm G, Rüttiger L, Knipper M, Lang F. AMP-activated protein kinase in BK-channel regulation and protection against hearing loss following acoustic overstimulation. FASEB J. 2012;26(10):4243-53.

32: Henrion U, Zumhagen S, Steinke K, Strutz-Seebohm N, Stallmeyer B, Lang F, Schulze-Bahr E, Seebohm G. Overlapping cardiac phenotype associated with a familial mutation in the voltage sensor of the KCNQ1 channel. Cell Physiol Biochem. 2012;29(5-6):809-18.

33: Wilmes J, Haddad-Tóvolli R, Alesutan I, Munoz C, Sopjani M, Pelzl L, Bogatikov E, Fedele G, Faggio C, Seebohm G, Föller M, Lang F. Regulation of KCNQ1/KCNE1 by β-catenin. Mol Membr Biol. 2012;29(3-4):87-94.

34: Seebohm G, Neumann S, Theiss C, Novkovic T, Hill EV, Tavaré JM, Lang F, Hollmann M, Manahan-Vaughan D, Strutz-Seebohm N. Identification of a novel signaling pathway and its relevance for GluA1 recycling. PLoS One. 2012;7(3):e33889.

35: Munoz C, Tóvolli RH, Sopjani M, Alesutan I, Lam RS, Seebohm G, Föller M, Lang F. Activation of voltage gated K⁺ channel Kv1.5 by β-catenin. Biochem Biophys Res Commun. 2012;417(2):692-6.

36: Seebohm G, Strutz-Seebohm N, Ursu ON, Preisig-Müller R, Zuzarte M, Hill EV, Kienitz MC, Bendahhou S, Fauler M, Tapken D, Decher N, Collins A, Jurkat-Rott K, Steinmeyer K, Lehmann-Horn F, Daut J, Tavaré JM, Pott L, Bloch W, Lang F. Altered stress stimulation of inward rectifier potassium channels in Andersen-Tawil syndrome. FASEB J. 2012;26(2):513-22.

37: Strutz-Seebohm N, Pusch M, Wolf S, Stoll R, Tapken D, Gerwert K, Attali B, Seebohm G. Structural basis of slow activation gating in the cardiac I Ks channel complex. Cell Physiol Biochem. 2011;27(5):443-52.

38: Alesutan I, Munoz C, Sopjani M, Dërmaku-Sopjani M, Michael D, Fraser S, Kemp BE, Seebohm G, Föller M, Lang F. Inhibition of Kir2.1 (KCNJ2) by the AMP-activated protein kinase. Biochem Biophys Res Commun. 2011;408(4):505-10. 

39: Wrobel E, Seebohm G. Potential in targeting classical inward rectifier channels. Heart Rhythm. 2011;8(7):1081-2.

40: Alesutan I, Föller M, Sopjani M, Dërmaku-Sopjani M, Zelenak C, Fröhlich H, Velic A, Fraser S, Kemp BE, Seebohm G, Völkl H, Lang F. Inhibition of the heterotetrameric K+ channel KCNQ1/KCNE1 by the AMP-activated protein kinase. Mol Membr Biol. 2011;28(2):79-89.

41: Eckey K, Strutz-Seebohm N, Katz G, Fuhrmann G, Henrion U, Pott L, Linke WA, Arad M, Lang F, Seebohm G. Modulation of human ether a gogo related channels by CASQ2 contributes to etiology of catecholaminergic polymorphic ventricular tachycardia (CPVT). Cell Physiol Biochem. 2010;26(4-5):503-12.

42: Fröhlich H, Boini KM, Seebohm G, Strutz-Seebohm N, Ureche ON, Föller M, Eichenmüller M, Shumilina E, Pathare G, Singh AK, Seidler U, Pfeifer KE, Lang F. Hypothyroidism of gene-targeted mice lacking Kcnq1. Pflugers Arch. 2011;461(1):45-52.

Pubikationen 2006-2010 (34)

1: Cavara NA, Orth A, Hicking G, Seebohm G, Hollmann M. Residues at the tip of the pore loop of NR3B-containing NMDA receptors determine Ca2+ permeability and Mg2+ block. BMC Neurosci. 2010 Oct 19;11:133. doi: 10.1186/1471-2202-11-133.

2: Lang F, Strutz-Seebohm N, Seebohm G, Lang UE. Significance of SGK1 in the regulation of neuronal function. J Physiol. 2010 Sep 15;588(Pt 18):3349-54.

3: Maljevic S, Wuttke TV, Seebohm G, Lerche H. KV7 channelopathies. Pflugers Arch. 2010 Jul;460(2):277-88. doi: 10.1007/s00424-010-0831-3.

4: Alesutan IS, Ureche ON, Laufer J, Klaus F, Zürn A, Lindner R, Strutz-Seebohm N, Tavaré JM, Boehmer C, Palmada M, Lang UE, Seebohm G, Lang F. Regulation of the glutamate transporter EAAT4 by PIKfyve. Cell Physiol Biochem. 2010;25(2-3):187-94.

5: Gehring EM, Zurn A, Klaus F, Laufer J, Sopjani M, Lindner R, Strutz-Seebohm N, Tavaré JM, Boehmer C, Palmada M, Lang UE, Seebohm G, Lang F. Regulation of the glutamate transporter EAAT2 by PIKfyve. Cell Physiol Biochem. 2009;24(5-6):361-8.

6: Gehring EM, Lam RS, Siraskar G, Koutsouki E, Seebohm G, Ureche ON, Ureche L, Baltaev R, Tavare JM, Lang F. PIKfyve upregulates CFTR activity. Biochem Biophys Res Commun. 2009 Dec 18;390(3):952-7. doi: 10.1016/j.bbrc.2009.10.084.

7: Fedorenko O, Tang C, Sopjani M, Föller M, Gehring EM, Strutz-Seebohm N, Ureche ON, Ivanova S, Semke A, Lang F, Seebohm G, Lang UE. PIP5K2A-dependent regulation of excitatory amino acid transporter EAAT3. Psychopharmacology (Berl). 2009 Oct;206(3):429-35.

8: Henrion U, Strutz-Seebohm N, Duszenko M, Lang F, Seebohm G. Long QT syndrome-associated mutations in the voltage sensor of I(Ks) channels. Cell Physiol Biochem. 2009;24(1-2):11-6.

9: Seebohm G. Kv7.1 in atrial fibrillation. Heart Rhythm. 2009 Aug;6(8):1154-5.

10: Klaus F, Gehring EM, Zürn A, Laufer J, Lindner R, Strutz-Seebohm N, Tavaré JM, Rothstein JD, Boehmer C, Palmada M, Gruner I, Lang UE, Seebohm G, Lang F. Regulation of the Na(+)-coupled glutamate transporter EAAT3 by PIKfyve. Neurochem Int. 2009 May-Jun;54(5-6):372-7.

11: Strutz-Seebohm N, Henrion U, Steinke K, Tapken D, Lang F, Seebohm G. Serum-and glucocorticoid-inducible kinases (SGK) regulate KCNQ1/KCNE potassium channels. Channels (Austin). 2009 Mar-Apr;3(2):88-90.

12: Ureche ON, Ureche L, Henrion U, Strutz-Seebohm N, Bundis F, Steinmeyer K, Lang F, Seebohm G. Differential modulation of cardiac potassium channels by Grb adaptor proteins. Biochem Biophys Res Commun. 2009 Jun 19;384(1):28-31.

13: Klaus F, Laufer J, Czarkowski K, Strutz-Seebohm N, Seebohm G, Lang F. PIKfyve-dependent regulation of the Cl- channel ClC-2. Biochem Biophys Res Commun. 2009 Apr 10;381(3):407-11. doi: 10.1016/j.bbrc.2009.02.053.

14: Lange W, Geissendörfer J, Schenzer A, Grötzinger J, Seebohm G, Friedrich T, Schwake M. Refinement of the binding site and mode of action of the anticonvulsant Retigabine on KCNQ K+ channels. Mol Pharmacol. 2009 Feb;75(2):272-80.

15: Seebohm G, Strutz-Seebohm N, Ureche ON, Henrion U, Baltaev R, Mack AF, Korniychuk G, Steinke K, Tapken D, Pfeufer A, Kääb S, Bucci C, Attali B, Merot J, Tavare JM, Hoppe UC, Sanguinetti MC, Lang F. Long QT syndrome-associated mutations in KCNQ1 and KCNE1 subunits disrupt normal endosomal recycling of IKs channels. Circ Res. 2008 Dec 5;103(12):1451-7.

15: Morokuma J, Blackiston D, Adams DS, Seebohm G, Trimmer B, Levin M. Modulation of potassium channel function confers a hyperproliferative invasive phenotype on embryonic stem cells. Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16608-13.

16: Fedorenko O, Strutz-Seebohm N, Henrion U, Ureche ON, Lang F, Seebohm G, Lang UE. A schizophrenia-linked mutation in PIP5K2A fails to activate neuronal M channels. Psychopharmacology (Berl). 2008 Jul;199(1):47-54.

17: Ureche ON, Baltaev R, Ureche L, Strutz-Seebohm N, Lang F, Seebohm G. Novel insights into the structural basis of pH-sensitivity in inward rectifier K+ channels Kir2.3. Cell Physiol Biochem. 2008;21(5-6):347-56.

18: Weber YG, Storch A, Wuttke TV, Brockmann K, Kempfle J, Maljevic S, Margari L, Kamm C, Schneider SA, Huber SM, Pekrun A, Roebling R, Seebohm G, Koka S, Lang C, Kraft E, Blazevic D, Salvo-Vargas A, Fauler M, Mottaghy FM, Münchau A, Edwards MJ, Presicci A, Margari F, Gasser T, Lang F, Bhatia KP, Lehmann-Horn F, Lerche H. GLUT1 mutations are a cause of paroxysmal exertion-induced dyskinesias and induce hemolytic anemia by a cation leak. J Clin Invest. 2008 Jun;118(6):2157-68.

19: Wuttke TV, Penzien J, Fauler M, Seebohm G, Lehmann-Horn F, Lerche H, Jurkat-Rott K. Neutralization of a negative charge in the S1-S2 region of the KV7.2 (KCNQ2) channel affects voltage-dependent activation in neonatal epilepsy. J Physiol. 2008 Jan 15;586(2):545-55.

20: Strutz-Seebohm N, Gutcher I, Decher N, Steinmeyer K, Lang F, Seebohm G. Comparison of potent Kv1.5 potassium channel inhibitors reveals the molecular basis for blocking kinetics and binding mode. Cell Physiol Biochem. 2007;20(6):791-800.

21: Strutz-Seebohm N, Shojaiefard M, Christie D, Tavare J, Seebohm G, Lang F. PIKfyve in the SGK1 mediated regulation of the creatine transporter SLC6A8. Cell Physiol Biochem. 2007;20(6):729-34.

22: Koutsouki E, Lam RS, Seebohm G, Ureche ON, Ureche L, Baltaev R, Lang F. Modulation of human Kv1.5 channel kinetics by N-cadherin. Biochem Biophys Res Commun. 2007 Nov 9;363(1):18-23.

23: Paul J, Jeyaraj S, Huber SM, Seebohm G, Böhmer C, Lang F, Kremsner PG, Kun JF. Alterations in the cytoplasmic domain of CLCN2 result in altered gating kinetics. Cell Physiol Biochem. 2007;20(5):441-54.

24: Gibor G, Yakubovich D, Rosenhouse-Dantsker A, Peretz A, Schottelndreier H, Seebohm G, Dascal N, Logothetis DE, Paas Y, Attali B. An inactivation gate in the selectivity filter of KCNQ1 potassium channels. Biophys J. 2007 Dec 15;93(12):4159-72.

25: Shojaiefard M, Strutz-Seebohm N, Tavaré JM, Seebohm G, Lang F. Regulation of the Na(+), glucose cotransporter by PIKfyve and the serum and glucocorticoid inducible kinase SGK1. Biochem Biophys Res Commun. 2007 Aug 10;359(4):843-7.

26: Lerche C, Bruhova I, Lerche H, Steinmeyer K, Wei AD, Strutz-Seebohm N, Lang F, Busch AE, Zhorov BS, Seebohm G. Chromanol 293B binding in KCNQ1 (Kv7.1) channels involves electrostatic interactions with a potassium ion in the selectivity filter. Mol Pharmacol. 2007 Jun;71(6):1503-11.

27: Seebohm G, Strutz-Seebohm N, Birkin R, Dell G, Bucci C, Spinosa MR, Baltaev R, Mack AF, Korniychuk G, Choudhury A, Marks D, Pagano RE, Attali B, Pfeufer A, Kass RS, Sanguinetti MC, Tavare JM, Lang F. Regulation of endocytic recycling of KCNQ1/KCNE1 potassium channels. Circ Res. 2007 Mar 16;100(5):686-92.

28: Strutz-Seebohm N, Korniychuk G, Schwarz R, Baltaev R, Ureche ON, Mack AF, Ma ZL, Hollmann M, Lang F, Seebohm G. Functional significance of the kainite receptor GluR6(M836I) mutation that is linked to autism. Cell Physiol Biochem. 2006;18(4-5):287-94.

29: Lang F, Böhmer C, Palmada M, Seebohm G, Strutz-Seebohm N, Vallon V. (Patho)physiological significance of the serum- and glucocorticoid-inducible kinase isoforms. Physiol Rev. 2006 Oct;86(4):1151-78.

30: Strutz-Seebohm N, Seebohm G, Fedorenko O, Baltaev R, Engel J, Knirsch M, Lang F. Functional coassembly of KCNQ4 with KCNE-beta- subunits in Xenopus oocytes. Cell Physiol Biochem. 2006;18(1-3):57-66.

31: Frey A, Lampert A, Waldegger S, Jeck N, Waldegger P, Artunc F, Seebohm G, Lang UE, Kupka S, Pfister M, Hoppe J, Gerloff C, Schaeffeler E, Schwab M, Lang F. Influence of gain of function epithelial chloride channel ClC-Kb mutation on hearing thresholds. Hear Res. 2006 Apr;214(1-2):68-75.

32: Strutz-Seebohm N, Seebohm G, Korniychuk G, Baltaev R, Ureche O, Striegel M, Lang F. Additive regulation of GluR1 by stargazin and serum- and glucocorticoid-inducible kinase isoform SGK3. Pflugers Arch. 2006 Jun;452(3):276-82.

33: Seebohm G, Strutz-Seebohm N, Ureche ON, Baltaev R, Lampert A, Kornichuk G, Kamiya K, Wuttke TV, Lerche H, Sanguinetti MC, Lang F. Differential roles of S6 domain hinges in the gating of KCNQ potassium channels. Biophys J. 2006 Mar 15;90(6):2235-44.

34: Lang UE, Wolfer DP, Grahammer F, Strutz-Seebohm N, Seebohm G, Lipp HP, McCormick JA, Hellweg R, Dawson K, Wang J, Pearce D, Lang F. Reduced locomotion in the serum and glucocorticoid inducible kinase 3 knock out mouse. Behav Brain Res. 2006 Feb 15;167(1):75-86.

Publikationen 2000-2005 (22)

1: Seebohm G, Strutz-Seebohm N, Baltaev R, Korniychuk G, Knirsch M, Engel J, Lang F. Regulation of KCNQ4 potassium channel prepulse dependence and current amplitude by SGK1 in Xenopus oocytes. Cell Physiol Biochem. 2005;16(4-6):255-62.

2: Ullrich S, Berchtold S, Ranta F, Seebohm G, Henke G, Lupescu A, Mack AF, Chao CM, Su J, Nitschke R, Alexander D, Friedrich B, Wulff P, Kuhl D, Lang F. Serum-and glucocorticoid-inducible kinase 1 (SGK1) mediates glucocorticoid-induced inhibition of insulin secretion. Diabetes. 2005 Apr;54(4):1090-9.

3: Strutz-Seebohm N, Seebohm G, Mack AF, Wagner HJ, Just L, Skutella T, Lang UE, Henke G, Striegel M, Hollmann M, Rouach N, Nicoll RA, McCormick JA, Wang J, Pearce D, Lang F. Regulation of GluR1 abundance in murine hippocampal neurones by serum- and glucocorticoid-inducible kinase 3. J Physiol. 2005 Jun 1;565(Pt2):381-90.

4: Strutz-Seebohm N, Seebohm G, Shumilina E, Mack AF, Wagner HJ, Lampert A, Grahammer F, Henke G, Just L, Skutella T, Hollmann M, Lang F. Glucocorticoid adrenal steroids and glucocorticoid-inducible kinase isoforms in the regulation of GluR6 expression. J Physiol. 2005 Jun 1;565(Pt 2):391-401. Epub 2005 Mar 17.

5: Wuttke TV, Seebohm G, Bail S, Maljevic S, Lerche H. The new anticonvulsant retigabine favors voltage-dependent opening of the Kv7.2 (KCNQ2) channel by binding to its activation gate. Mol Pharmacol. 2005 Apr;67(4):1009-17.

6: Seebohm G, Westenskow P, Lang F, Sanguinetti MC. Mutation of colocalized residues of the pore helix and transmembrane segments S5 and S6 disrupt deactivation and modify inactivation of KCNQ1 K+ channels. J Physiol. 2005 Mar 1;563(Pt 2):359-68.

7: Seebohm G. Activators of cation channels: potential in treatment of channelopathies. Mol Pharmacol. 2005 Mar;67(3):585-8. Epub 2004 Dec 17.

8: Baltaev R, Strutz-Seebohm N, Korniychuk G, Myssina S, Lang F, Seebohm G. Regulation of cardiac shal-related potassium channel Kv 4.3 by serum- and glucocorticoid-inducible kinase isoforms in Xenopus oocytes. Pflugers Arch. 2005 Apr;450(1):26-33. Epub 2004 Dec 1. PubMed PMID: 15578212.

9: Busjahn A, Seebohm G, Maier G, Toliat MR, Nürnberg P, Aydin A, Luft FC, Lang F. Association of the serum and glucocorticoid regulated kinase (sgk1) gene with QT interval. Cell Physiol Biochem. 2004;14(3):135-42.

10: Seebohm G, Pusch M, Chen J, Sanguinetti MC. Pharmacological activation of normal and arrhythmia-associated mutant KCNQ1 potassium channels. Circ Res. 2003 Nov 14;93(10):941-7.

11: Seebohm G, Sanguinetti MC, Pusch M. Tight coupling of rubidium conductanceand inactivation in human KCNQ1 potassium channels. J Physiol. 2003 Oct 15;552(Pt2):369-78. Erratum in: J Physiol. 2004 May 1;556(Pt 3):1013.

12: Strutz-Seebohm N, Werner M, Madsen DM, Seebohm G, Zheng Y, Walker CS, Maricq AV, Hollmann M. Functional analysis of Caenorhabditis elegans glutamate receptor subunits by domain transplantation. J Biol Chem. 2003 Nov 7;278(45):44691-701.

13: Seebohm G, Chen J, Strutz N, Culberson C, Lerche C, Sanguinetti MC. Molecular determinants of KCNQ1 channel block by a benzodiazepine. Mol Pharmacol. 2003 Jul;64(1):70-7.

14: Rose U, Seebohm G, Hustert R. The role of internal pressure and muscle activation during locust oviposition. J Insect Physiol. 2000 Jan;46(1):69-80.

15: Maljevic S, Lerche C, Seebohm G, Alekov AK, Busch AE, Lerche H. C-terminal interaction of KCNQ2 and KCNQ3 K+ channels. J Physiol. 2003 Apr 15;548(Pt2):353-60. Epub 2003 Mar 14.

16: Chen J, Seebohm G, Sanguinetti MC. Position of aromatic residues in the S6 domain, not inactivation, dictates cisapride sensitivity of HERG and eag potassium channels. Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12461-6.

17: Seebohm G, Lerche C, Pusch M, Steinmeyer K, Brüggemann A, Busch AE. A kinetic study on the stereospecific inhibition of KCNQ1 and I(Ks) by the chromanol 293B. Br J Pharmacol. 2001 Dec;134(8):1647-54.

18: Seebohm G, Lerche C, Busch AE, Bachmann A. Dependence of I(Ks) biophysical properties on the expression system. Pflugers Arch. 2001 Sep;442(6):891-5.

19: Liu GX, Derst C, Schlichthörl G, Heinen S, Seebohm G, Brüggemann A, Kummer W, Veh RW, Daut J, Preisig-Müller R. Comparison of cloned Kir2 channels with native inward rectifier K+ channels from guinea-pig cardiomyocytes. J Physiol. 2001 Apr 1;532(Pt 1):115-26.

20: Seebohm G, Scherer CR, Busch AE, Lerche C. Identification of specific pore residues mediating KCNQ1 inactivation. A novel mechanism for long QT syndrome. J Biol Chem. 2001 Apr 27;276(17):13600-5.

21: Lerche C, Seebohm G, Wagner CI, Scherer CR, Dehmelt L, Abitbol I, Gerlach U, Brendel J, Attali B, Busch AE. Molecular impact of MinK on the enantiospecific block of I(Ks) by chromanols. Br J Pharmacol. 2000 Dec;131(8):1503-6.

22: Lerche C, Scherer CR, Seebohm G, Derst C, Wei AD, Busch AE, Steinmeyer K. Molecular cloning and functional expression of KCNQ5, a potassium channel subunit that may contribute to neuronal M-current diversity. J Biol Chem. 2000 Jul 21;275(29):22395-400.