Investigation of Endothelial Permeability Using Novel BODIPY Nanostructures

In this project, we are investigating a novel multimodal imaging approach using BODIPY-based nanostructures to study endothelial permeability in response to inflammatory stimuli in vivo. The variable size (ranging from a few nanometers to several micrometers) and shape (spherical, 1D, 2D) of the nanostructures enable a quantitative assessment of endothelial barrier function using multiscale imaging modalities. This project is being conducted within the framework of Collaborative Research Center 1450 “inSight” and takes place in close cooperation with the Department of Organic Chemistry (Prof. Gustavo Fernández).