Akademischer Rat des Instituts für Physiologie I
Robert-Koch-Str. 27 a
+ 49 251-83-55544 (phone)
+ 49 251-83-55551 (fax)

  • Curriculum vitae

    since 11/2011 Research associate at the Institute of Physiology I (Neurophysiology, Prof. Hans-Christian Pape), Westfälische Wilhelms-University Münster, Germany
    7/2006 – 10/2011 Postdoctoral fellow with Prof. Kai Kaila at the University of Helsinki, Finland
    6/2006 Dissertation: “Regulation of the K+-Cl--cotransporter 2 and the development of the auditory brainstem“
    4/2003 – 3/2006 Doctoral thesis, Neurobiology
    (Prof. Eckhard Friauf, University of Kaiserslautern, Germany)
    10/1998 – 3/2003 Diploma in biology at the department of Animal Physiology
    (Prof. Eckhard Friauf, University of Kaiserslautern, Germany)
    1989 – 1998 Secondary school, Neckarsulm, Germany
    1985 – 1989 Elementary school, Neckarsulm, Germany


    • Graduierten-Stipendium der Novartis-Stiftung für therapeutische Forschung 2012
    • Preis des Freundeskreises der Technischen Universität Kaiserslautern e.V. für eine wissenschaftlich hervorragende Doktorarbeit im Jahr 2006
  • Publications


    1. Jüngling K, Blaesse P, Goedecke L, Pape HC (2016) Dynorphin-dependent reduction of excitability and attenuation of inhibitory afferents of NPS neurons in the pericoerulear region of mice. Front Cell Neurosci 10:61.


    1. Puskarjov M, Ahmad F, Khirug S, Sivakumaran S, Kaila K, Blaesse P (2015) BDNF is required for seizure-induced but not developmental up-regulation of KCC2 in the neonatal hippocampus.
      Neuropharmacology 88: 103-109
    2. Blaesse P, Goedecke L, Bazelot M, Capogna M, Pape HC, Jüngling K (2015) μ-opioid receptor-mediated inhibition of intercalated neurons and effect on synaptic transmission to the central amygdala. J Neurosci 35:7317-25.
    3. Romo-Parra H, Blaesse P, Sosulina L, Pape HC (2015) Neurosteroids increase tonic GABAergic inhibition in the lateral section of the central amygdala in mice. J Neurophysiol 113:3421-31.
      Erdmann F, Kügler S, Blaesse P, Lange MD, Skryabin BV, Pape HC, Jüngling K (2015) Neuronal expression of the human neuropeptide S receptor NPSR1 identifies NPS-induced calcium signaling pathways. PLoS One 10:e0117319.
    4. Blaesse P, Schmidt T (2015) K-Cl cotransporter KCC2--a moonlighting protein in excitatory and inhibitory synapse development and function. Pflugers Arch 467:615-24.


    1. Lange MD, Jüngling K, Paulukat L, Vieler M, Gaburro S, Sosulina L, Blaesse P, Sreepathi HK, Ferraguti F, Pape HC (2014)
      Glutamic acid decarboxylase 65: a link between GABAergic synaptic plasticity in the lateral amygdala and conditioned fear generalization.
      Neuropsychopharmacology 39(9): 2211-20.
    2. Puskarjov M, Seja P, Heron SE, Williams TC, Ahmad F, Iona X, Oliver KL, Grinton BE, Vutskits L, Scheffer IE, Petrou S, Blaesse P, Dibbens LM, Berkovic SF, Kaila K (2014) A variant of KCC2 from patients with febrile seizures impairs neuronal Cl- extrusion and dendritic spine formation.
      EMBO Rep. 15(6): 723-9.
    3. Blaesse P, Schmidt T (2014) K-Cl cotransporter KCC2-a moonlighting protein in excitatory and inhibitory synapse development and function.
      Pflugers Arch.  [Epub ahead of print]


    1. Ruusuvuori E, Huebner AK, Kirilkin I, Yukin AY, Blaesse P, Helmy M, Kang HJ, El Muayed M, Hennings JC, Voipio J, Šestan N, Hübner CA, Kaila K (2013) Neuronal carbonic anhydrase VII provides GABAergic excitatory drive to exacerbate febrile seizures.
      EMBO J. 32(16): 2275-86.
    2. Ahmad F, Kaila K, Blaesse P (2013) Quantitative analysis of surface expression of membrane proteins using cold-adapted proteases.
      Curr Protoc Protein Sci. 73: Unit 3.11.


    1. Puskarjov M, Ahmad F, Kaila K, Blaesse P (2012) Activity-dependent cleavage of the K-Cl cotransporter KCC2 mediated by calcium-activated protease calpain. J Neurosci 32: 11356-11364.
    2. Fiumelli H, Briner A, Puskarjov M, Blaesse P, Belem BJ, Dayer AG, Kaila K, Martin JL, Vutskits L (2012) An ion transport-independent role for the cation-chloride cotransporter KCC2 in dendritic spinogenesis in vivo. Cereb Cortex 23: 378-388.


    1. Ahmad F, Coleman SK, Kaila K, Blaesse P (2011) Cold-adapted protease enables quantitation of surface proteins in the absence of membrane trafficking. Biotechniques 50:255-257.


    1. Horn Z, Ringstedt T, Blaesse P, Kaila K, Herlenius E (2010) Premature expression of KCC2 in embryonic mice perturbs neural development by an ion transport-independent mechanism. Eur J Neurosci 31:2142-2155.
    2. Khirug S, Ahmad F, Puskarjov M, Afzalov R, Kaila K, Blaesse P (2010) A single seizure episode leads to rapid functional activation of KCC2 in the neonatal rat hippocampus. J Neurosci 30:12028-12035.


    1. Blaesse P, Airaksinen MS, Rivera C, Kaila K (2009) Cation-chloride cotransporters and neuronal function. Neuron 61:820-838.
    2. Hartmann AM, Blaesse P, Kranz T, Wenz M, Schindler J, Kaila K, Friauf E, Nothwang HG (2009) Opposite effect of membrane raft perturbation on transport activity of KCC2 and NKCC1. J Neurochem 111:321-331.
    3. Sipila ST, Huttu K, Yamada J, Afzalov R, Voipio J, Blaesse P, Kaila K (2009) Compensatory enhancement of intrinsic spiking upon NKCC1 disruption in neonatal hippocampus. J Neurosci 29:6982-6988.


    1. Blaesse P, Nothwang HG (2008) Neuronal chloride homeostasis: development and activity-dependent regulation of cation-chloride cotransporters. Neuroforum, 1:148-157


    1. Li H, Khirug S, Cai C, Ludwig A, Blaesse P, Kolikova J, Afzalov R, Coleman SK, Lauri S, Airaksinen MS, Keinanen K, Khiroug L, Saarma M, Kaila K, Rivera C (2007) KCC2 interacts with the dendritic cytoskeleton to promote spine development. Neuron 56:1019-1033.


    1. Blaesse P, Guillemin I, Schindler J, Schweizer M, Delpire E, Khiroug L, Friauf E, Nothwang HG (2006) Oligomerization of KCC2 correlates with development of inhibitory neurotransmission. J Neurosci 26:10407-10419.


    1. Blaesse P, Ehrhardt S, Friauf E, Nothwang HG (2005) Developmental pattern of three vesicular glutamate transporters in the rat superior olivary complex. Cell Tissue Res 320:33-50.

    Book chapters

    1. Miles R, Blaesse P, Huberfeld G, Wittner L, Kaila K (2012) Chloride homeostasis and GABA signaling in temporal lobe epilepsy. In: Jasper's Basic Mechanisms of the Epilepsies, Eds: Noebels J, Avoli M, Rogawski M, Olsen R, Delgado-Escueta A, Oxford University Press; 4th edition. Bethesda (MD): National Center for Biotechnology Information (US)
    2. Kaila K, Blaesse P, Sipilä ST. (2009) Development of GABAergic signaling: from molecules to emerging networks. In: Developmental and comparative neuroscience: Epigenetics, Evolution, & Behavior, Eds: Blumberg MS, Freeman JH, Robinson SR, Oxford University Press; pp 108-39