2024

Groh AC, Möller-Kerutt A, Gilhaus K, Höffken V, Nedvetsky P, Kleimann S, Behrens M, Ghosh S, Hansen U, Krahn MP, Ebnet K, Pavenstädt H, Ludwig A, Weide T. PALS1 is a key regulator of the lateral distribution of tight junction proteins in renal epithelial cells. J Cell Sci. 2024 Mar 1;137(5):jcs261303. doi: 10.1242/jcs.261303. Epub 2024 Jan 24. PMID: 38265145.

2022/2023

Fiedler J, Moennig T, Hinrichs JH, Weber A, Wagner T, Hemmer T, Schröter R, Weide T, Epting D, Bergmann C, Nedvetsky P, Krahn MP. PATJ inhibits histone deacetylase 7 to control tight junction formation and cell polarity. Cell Mol Life Sci. 2023 Oct 25;80(11):333. doi: 10.1007/s00018-023-04994-3. PMID: 37878054; PMCID: PMC10600057.

Grampp S, Krüger R, Lauer V, Uebel S, Knaup KX, Naas J, Höffken V, Weide T, Schiffer M, Naas S, Schödel J. Hypoxia hits APOL1 in the kidney. Kidney Int. 2023 Jul;104(1):53-60. doi: 10.1016/j.kint.2023.03.035. Epub 2023 Apr 23. PMID: 37098381.

Vöing K, Michgehl U, Mertens ND, Picciotto C, Maywald ML, Goretzko J, Waimann S, Gilhaus K, Rogg M, Schell C, Klingauf J, Tsytsyura Y, Hansen U, van Marck V, Edinger AL, Vollenbröker B, Rescher U, Braun DA, George B, Weide T, Pavenstädt H. Disruption of the Rab7-Dependent Final Common Pathway of Endosomal and Autophagic Processing Results in a Severe Podocytopathy. J Am Soc Nephrol. 2023 Jul 1;34(7):1191-1206. doi: 10.1681/ASN.0000000000000126. Epub 2023 Apr 5. PMID: 37022133; PMCID: PMC10356157.

Krausel V, Pund L, Nüsse H, Bachir H, Ricker A, Klingauf J, Weide T, Pavenstädt H, Krahn MP, Braun DA. The transcription factor ATF4 mediates endoplasmic reticulum stress-related podocyte injury and slit diaphragm defects. Kidney Int. 2023 May;103(5):872-885. doi: 10.1016/j.kint.2022.11.024. Epub 2022 Dec 29. PMID: 36587794.

Möller-Kerutt A, Schönhoff B, Rellmann Y, George B, Braun DA, Pavenstädt H, Weide T. Loss of surface transport is a main cellular pathomechanism of CRB2 variants causing podocytopathies. Life Sci Alliance. 2022 Dec 22;6(3):e202201649. doi: 10.26508/lsa.202201649. PMID: 36549870; PMCID: PMC9780758.

Berghaus C, Groh AC, Breljak D, Ciarimboli G, Sabolić I, Pavenstädt H, Weide T. Impact of Pals1 on Expression and Localization of Transporters Belonging to the Solute Carrier Family. Front Mol Biosci. 2022 Feb 16;9:792829. doi: 10.3389/fmolb.2022.792829. PMID: 35252349; PMCID: PMC8888964.

2020/2021

Jehn U, Bayraktar S, Pollmann S, Van Marck V, Weide T, Pavenstädt H, Brand E, Lenders M. α-Galactosidase a Deficiency in Fabry Disease Leads to Extensive Dysregulated Cellular Signaling Pathways in Human Podocytes. Int J Mol Sci. 2021 Oct 20;22(21):11339. doi: 10.3390/ijms222111339. PMID: 34768768; PMCID: PMC8583658.

Müller D, Schmitz J, Fischer K, Granado D, Groh AC, Krausel V, Lüttgenau SM, Amelung TM, Pavenstädt H, Weide T. Evolution of Renal-Disease Factor APOL1 Results in Cis and Trans Orientations at the Endoplasmic Reticulum That Both Show Cytotoxic Effects. Mol Biol Evol. 2021 Oct 27;38(11):4962-4976. doi: 10.1093/molbev/msab220. PMID: 34323996; PMCID: PMC8557400.

Möller-Kerutt A, Rodriguez-Gatica JE, Wacker K, Bhatia R, Siebrasse JP, Boon N, Van Marck V, Boor P, Kubitscheck U, Wijnholds J, Pavenstädt H, Weide T. Crumbs2 Is an Essential Slit Diaphragm Protein of the Renal Filtration Barrier. J Am Soc Nephrol. 2021 May 3;32(5):1053-1070. doi: 10.1681/ASN.2020040501. Epub 2021 Mar 9. PMID: 33687977; PMCID: PMC8259666.

Lepa C, Hoppe S, Stöber A, Skryabin BV, Sievers LK, Heitplatz B, Ciarimboli G, Neugebauer U, Lindenmeyer MT, Cohen CD, Drexler HCA, Boor P, Weide T, Pavenstädt H, George B. TrkC Is Essential for Nephron Function and Trans-Activates Igf1R Signaling. J Am Soc Nephrol. 2021 Feb;32(2):357-374. doi: 10.1681/ASN.2020040424. Epub 2020 Dec 30. PMID: 33380522; PMCID: PMC8054883.

Lepa C, Möller-Kerutt A, Stölting M, Picciotto C, Eddy ML, Butt E, Kerjaschki D, Korb-Pap A, Vollenbröker B, Weide T, George B, Kremerskothen J, Pavenstädt H. LIM and SH3 protein 1 (LASP-1): A novel link between the slit membrane and actin cytoskeleton dynamics in podocytes. FASEB J. 2020 Apr;34(4):5453-5464. doi: 10.1096/fj.201901443R. Epub 2020 Feb 21. PMID: 32086849.

2018/2019

Dlugos CP, Picciotto C, Lepa C, Krakow M, Stöber A, Eddy M-L, Weide T, Jeibmann A, Krahn MP, Van Marck V, Klingauf J, Ricker A, Wedlich-Söldner R, Pavenstädt H, Klämbt C, George B. Nephrin Signaling Results in Integrin β 1 Activation. J Am Soc Nephrol (2019).

Bonse J, Wennmann DO, Kremerskothen J, Weide T, Michgehl U, Pavenstädt H, Vollenbröker B. Nuclear YAP localization as a key regulator of podocyte function. Cell Death Dis. 2018 Aug 28;9(9):850. doi: 10.1038/s41419-018-0878-1. PMID: 30154411; PMCID: PMC6113334.

Michgehl U, Skryabin BV, Bayraktar S, Vollenbröker B, Ciarimboli G, Heitplatz B, Van Marck V, Gröne HJ, Pavenstädt H, Weide T. Nephron-specific knockin of the PIKfyve-binding-deficient Vac14L156R mutant results in albuminuria and mesangial expansion. Am J Physiol Renal Physiol. 2018 Nov 1;315(5):F1307-F1319. doi: 10.1152/ajprenal.00191.2018. Epub 2018 Aug 1. PMID: 30066585.

Schutte-Nutgen K, Edeling M, Mendl G, Krahn MP, Edemir B, Weide T, Kremerskothen J, Michgehl U, Pavenstadt H. Getting a Notch closer to renal dysfunction: Activated Notch suppresses expression of the adaptor protein Disabled-2 in tubular epithelial cells. FASEB J. (2019).

2016/2017

Granado D, Müller D, Krausel V, Kruzel-Davila E, Schuberth C, Eschborn M, Wedlich-Söldner R, Skorecki K, Pavenstädt H, Michgehl U, Weide T. Intracellular APOL1 Risk Variants Cause Cytotoxicity Accompanied by Energy Depletion. J. Am. Soc. Nephrol. (2017).

Hochapfel F, Denk L, Mendl G, Schulze U, Maaßen C, Zaytseva Y, Pavenstädt H, Weide T, Rachel R, Witzgall R, Krahn MP. Distinct functions of Crumbs regulating slit diaphragms and endocytosis in Drosophila nephrocytes. Cell. Mol. Life Sci. (2017).

Schenk LK, Möller-Kerutt A, Klosowski R, Wolters D, Schaffner-Reckinger E, Weide T, Pavenstädt H, Vollenbröker B. Angiotensin II regulates phosphorylation of actin-associated proteins in human podocytes. FASEB J. (2017).

Schulze U, Vollenbröker B, Kühnl A, Granado D, Bayraktar S, Rescher U, Pavenstädt H, Weide T. Cellular vacuolization caused by overexpression of the PIKfyve-binding deficient Vac14L156R is rescued by starvation and inhibition of vacuolar-ATPase. Biochim. Biophys. Acta - Mol. Cell Res. (2017).

Brinkmann BF, Steinbacher T, Hartmann C, Kummer D, Pajonczyk D, Mirzapourshafiyi F, Nakayama M, Weide T, Gerke V, Ebnet K. VE-cadherin interacts with cell polarity protein Pals1 to regulate vascular lumen formation. Mol. Biol. Cell (2016).

Djuric I, Siebrasse JP, Schulze U, Granado D, Schlüter MA, Kubitscheck U, Pavenstädt H, Weide T. The C-terminal domain controls the mobility of Crumbs 3 isoforms. Biochim Biophys Acta - Mol Cell Res (2016).

Hessner F, Dlugos CP, Chehab T, Schaefer C, Homey B, Gerke V, Weide T, Pavenstädt H, Rescher U. CC chemokine receptor 10 cell surface presentation in melanocytes is regulated by the novel interaction partner S100A10. Sci. Rep. (2016).

Klionsky DJ et al . Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). (2016).

Schenk LK, Schulze U, Henke S, Weide T, Pavenstädt H. TMEM16F Regulates Baseline Phosphatidylserine Exposure and Cell Viability in Human Embryonic Kidney Cells. Cell. Physiol. Biochem. (2016).

Siebrasse JP, Djuric I, Schulze U, Schlüter MA, Pavenstädt H, Weide T, Kubitscheck U. Trajectories and single-particle tracking data of intracellular vesicles loaded with either SNAP-Crb3A or SNAP-Crb3B. Data Br. (2016).

2014/2015

Mojallal M, Zheng Y, Hultin S, Audebert S, Van Harn T, Johnsson P, Lenander C, Fritz N, Mieth C, Corcoran M, Lembo F, Hallström M, Hartman J, Mazure NM, Weide T, Grandér D, Borg JP, Uhlén P, Holmgren L. AmotL2 disrupts apical-basal cell polarity and promotes tumour invasion. Nat. Commun. (2014).

Wennmann DO, Schmitz J, Wehr MC, Krahn MP, Koschmal N, Gromnitza S, Schulze U, Weide T, Chekuri A, Skryabin B V., Gerke V, Pavenstädt H, Duning K, Kremerskothen J. Evolutionary and molecular facts link the WWC protein family to hippo signaling. Mol. Biol. Evol. (2014).

Wennmann DO, Vollenbröker B, Eckart AK, Bonse J, Erdmann F, Wolters DA, Schenk LK, Schulze U, Kremerskothen J, Weide T, Pavenstädt H. The Hippo pathway is controlled by Angiotensin II signaling and its reactivation induces apoptosis in podocytes. Cell Death Dis. (2014).

2012/2013

Duning K, Wennmann DO, Bokemeyer A, Reissner C, Wersching H, Thomas C, Buschert J, Guske K, Franzke V, Flöel A, Lohmann H, Knecht S, Brand SM, Pöter M, Rescher U, Missler M, Seelheim P, Pröpper C, Boeckers TM, Makuch L, Huganir R, Weide T, Brand E, Pavenstädt H, Kremerskothen J. Common exonic missense variants in the C2 domain of the human KIBRA protein modify lipid binding and cognitive performance. Transl. Psychiatry (2013).

Zolov SN, Bridges D, Zhang Y, Lee W-W, Riehle E, Verma R, Lenk GM, Converso-Baran K, Weide T, Albin RL, Saltiel AR, Meisler MH, Russell MW, Weisman LS. In vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P. Proc. Natl. Acad. Sci. (2012).

2010/2011

Aldag I, Bockau U, Rossdorf J, Laarmann S, Raaben W, Herrmann L, Weide T, Hartmann MWW. Expression, secretion and surface display of a human alkaline phosphatase by the ciliate Tetrahymena thermophila. BMC Biotechnol. (2011).

Edemir B, Pavenstädt H, Schlatter E, Weide T. Mechanisms of cell polarity and aquaporin sorting in the nephron. Pflugers Arch. Eur. J. Physiol. (2011).

Hsu HH, Hoffmann S, Di Marco GS, Endlich N, Peter-Katalinić J, Weide T, Pavenstädt H. Downregulation of the antioxidant protein peroxiredoxin 2 contributes to angiotensin II-mediated podocyte apoptosis. Kidney Int. (2011).

George B, Vollenbröker B, Saleem MA, Huber TB, Pavenstädt H, Weide T.  GSK3β inactivation in podocytes results in decreased phosphorylation of p70 S6K accompanied by cytoskeletal rearrangements and inhibited motility . Am. J. Physiol. Physiol. (2011).

Weide T, Huber TB. Implications of autophagy for glomerular aging and disease. Cell Tissue Res (2011).

Duning K, Rosenbusch D, Schlüter MAMA, Tian Y, Kunzelmann K, Meyer N, Schulze U, Markoff A, Pavenstädt H, Weide T. Polycystin-2 activity is controlled by transcriptional coactivator with PDZ binding motif and PALS1-associated tight junction protein. J Biol Chem (2010).

Vor 2010

Ernkvist M, Persson NL, Audebert S, Lecine P, Sinha I, Liu M, Schlueter M, Horowitz A, Aase K, Weide T, Borg JP, Majumdar A, Holmgren L. The Amot/Patj/Syx signaling complex spatially controls RhoA GTPase activity in migrating endothelial cells. Blood (2009).

Gutwein P, Schramme A, Abdel-Bakky MS, Doberstein K, Hauser IA, Ludwig A, Altevogt P, Gauer S, Hillmann A, Weide T, Jespersen C, Eberhardt W, Pfeilschifter J. ADAM10 is expressed in human podocytes and found in urinary vesicles of patients with glomerular kidney diseases. J. Biomed. Sci. (2010).

Hsu H-H, Duning K, Meyer HH, Stölting M, Weide T, Kreusser S, van Le T, Gerard C, Telgmann R, Brand-Herrmann S-M, Pavenstädt H, Bek MJ. Hypertension in mice lacking the CXCR3 chemokine receptor. Am. J. Physiol. Physiol. (2009).

Vollenbröker B, George B, Wolfgart M, Saleem MA, Pavenstädt H, Weide T. mTOR regulates expression of slit diaphragm proteins and cytoskeleton structure in podocytes. AmJ. Physiol. Ren. Physiol (2009).

Duning K, Schurek EM, Schlüter M, Bayer M, Reinhardt HC, Schwab A, Schaefer L, Benzing T, Schermer B, Saleem MA, Huber TB, Bachmann S, Kremerskothen J, Weide T, Pavenstädt H. KIBRA modulates directional migration of podocytes. J. Am. Soc. Nephrol. (2008).

Hsu HH, Hoffmann S, Endlich N, Velic A, Schwab A, Weide T, Schlatter E, Pavenstädt H. Mechanisms of angiotensin II signaling on cytoskeleton of podocytes. J. Mol. Med. (2008).

Weide T, Bockau U, Rave A, Herrmann L, Hartmann MWW. A recombinase system facilitates cloning of expression cassettes in the ciliate Tetrahymena thermophila. BMC Microbiol. (2007).

Herrmann L, Bockau U, Tiedtke A, Hartmann MWW, Weide T. The bifunctional dihydrofolate reductase thymidylate synthase of Tetrahymena thermophila provides a toll for molecular and biotechnology applications. BMC Biotechnol. (2006)

Bayer M, Fischer J, Kremerskothen J, Ossendorf E, Matanis T, Konczal M, Weide T, Barnekow A. Identification and characterization of Iporin as a novel interaction partner for rab 1. BMC Cell Biol. (2005).

Fischer J, Weide T, Barnekow A. The MICAL proteins and rab1: A possible link to the cytoskeleton? Biochem. Biophys. Res. Commun. (2005).

Matanis T, Akhmanova A, Wulf P, Del Nery E, Weide T, Stepanova T, Galjart N, Grosveld F, Goud B, De Zeeuw CI, Barnekow A, Hoogenraad CC. Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex. Nat Cell Biol  (2002).

Vogt-Eisele A, Krüger C, Duning K, Weber D, Spoelgen R, Pitzer C, Plaas C, Eisenhardt G, Meyer A, Vogt G, Krieger M, Handwerker E, Wennmann DO, Weide T, Skryabin B V., Klugmann M, Pavenstädt H, Huentelmann MJ, Kremerskothen J, Schneider A. KIBRA (KIdney/BRAin protein) regulates learning and memory and stabilizes Protein kinase Mζ. J. Neurochem. (2014).

Weide T, Bayer M, Köster M, Siebrasse JP, Peters R, Barnekow A. The Golgi matrix protein GM130: A specific interacting partner of the small GTPase rab1b. EMBO Rep. (2001). doi: 10.1093/embo-reports/kve065.

Weide T, Herrmann L, Bockau U, Niebur N, Aldag I, Laroy W, Contreras R, Tiedtke A, Hartmann MWW. Secretion of functional human enzymes by Tetrahymena thermophila. BMC Biotechnol. (2006). doi: 10.1186/1472-6750-6-19.

Weide T, Teuber J, Bayer M, Barnekow A. MICAL-1 isoforms, novel rab1 interacting proteins. Biochem. Biophys. Res. Commun. (2003). doi: 10.1016/S0006-291X(03)00918-5.

Weide T, Vollenbröker B, Schulze U, Djuric I, Edeling M, Bonse J, Hochapfel F, Panichkina O, Wennmann D-O, George B, Kim S, Daniel C, Seggewiß J, Amann K, Kriz W, Krahn MP, Pavenstädt H. Pals1 Haploinsufficiency Results in Proteinuria and Cyst Formation. J. Am. Soc. Nephrol. (2017). doi: 10.1681/ASN.2016040474.

Weide T, Koster M, Barnekow A. Inactive and active mutants of rab1b are not tightly integrated into target membranes. Int. J. Oncol. (1999)