Mucoid Staphylococcus aureus isolates in chronic respiratory infection in cystic fibrosis.

Characterization of mucoid Staphylococcus aureus isolates isolated from the airways of cystic fibrosis patients: Prevalence, clinical significance, and detailed analysis using molecular and imaging techniques.

In a multicenter study involving 13 centers with over 600 individuals with cystic fibrosis (PmCF), we demonstrate the prevalence of the previously little observed mucoid S. aureus isolates, investigate the underlying machanism, and analyze a possible association with clinical disease.

The project is funded by the DFG (KA 2249/5-1; 2018-2023)

IMF SC 11 19 11 - Phenotypical and genotypical analyses of unusual mucoid Staphylococcus aureus strains isolated from the airways of cystic fibrosis patients - (2019-2022)

The interaction of Staphylococcus aureus and Pseudomonas aeruginosa.

The interaction of Staphylococcus aureus and Pseudomonas aeruginosa in chronic respiratory infections of patients/individuals with cystic fibrosis (CF), primary ciliary dyskinesia (PCD), and chronic tracheostomy (CTT).

In this project, we are investigating the interaction of S. aureus and P. aeruginosa, which can be competitive (the pathogens inhibit each other) or commensal (both pathogens survive). Both pathogens commonly co-occur in chronic respiratory infections in CF, PCD, and CTT. A prospective observational study will be conducted to determine whether the specific interaction of the pathogens has an impact on the course of lung disease.

The project was funded by the Innovative Medical Research (IMF DA12 22 06) - (2023-2026).