Research Interest

We investigate the fundamental cell biological question how curvature-dependent self-organization impacts single and collective cell dynamics. To examine formation and function of curvature-induced signaling circuits, we employ cellular (e.g. neurons, immune cells and vascular cells) and biomimetic model systems that we analyze using advanced microscopy (e.g. lattice light-sheet microscopy, correlative light-electron microscopy, super-resolution microscopy), quantitative image analysis, nanomaterials, biophysical approaches, and numerical modelling. Our ultimate goal is to determine the core principles through which curvature-dependent self-organization regulates cellular physiology and development in health and disease.

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