MALDI mass spectrometry Imaging
We are further developing MALDI mass spectrometry imaging (MALDI-MSI for short) together with national and international cooperation partners from universities, clinics, and industry.

Our projects encompass basic physical and physicochemical research as well as instrumental innovations and novel applications of improved methodologies in biomedical research.

Our method development projects include, among others:

• the development of post-ionization methods (e.g. for laser-based MALDI-2) to increase ion yields and lower detection limits
• the further development of microbial MALDI-MSI
• the development of improved sample preparation protocols for these and other research questions

Closely linked to this are a number of fundamental studies.

Our more application-driven projects include:

• molecular analysis of neutrophils in tumors and bacterially infected tissues
• spatially resolved chemical analysis of microbial biofilms to visualize bacterial multicellularity and messenger substances
• improved imaging analysis of pharmaceuticals using MALDI-2
• chemical characterization of the retina with cell layer resolution to better understand neurodegenerative eye diseases and support the development of possible new pharmacological approaches