The Collaborative Research Centre TRR332 is a DFG-funded consortium dedicated to develop an improved understanding of neutrophil biology. Our studies will reveal mechanisms of how the tissue environment regulates neutrophil production and phenotypes, how neutrophil activity is controlled intracellularly and how neutrophils function in different disease contexts. Such approach will not only reveal important aspects of the fine-tuned regulatory mechanisms of neutrophil activation but also permit the generation of tailored intervention strategies.