Role of hippocampal BDNF signaling in contextual fear learning, fear generalization and context discrimination

Blum, Sendtner

The mossy fibre synapse in the mammalian hippocampus is thought to mediate context pattern separation to avoid fear generalization. Mossy fiber synapses in the hippocampus store high amounts of BDNF, a key regulator of synaptic plasticity, learning and memory. The aim of project A10 is to elucidate whether and how hippocampal mossy fibre BDNF affects the microcircuit in the stratum lucidum to modulate fear regulation, extinction, and fear generalization.

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