Human Preclinical Studies

In human preclinical studies, mechanisms involved in the regulation and dynamics of fear and anxiety will be investigated employing fear conditioning paradigms and experimental tools such as virtual reality and startle reflex modulation, stress system manipulations, fMRI, EEG or MEG.
These projects aim at identifiying neurobiological correlates of fear and anxiety taking into account (epi)-genetic, environment and life history perspectives.
Preclinical projects allow for the translational investigations in close analogy to animal research as well as clinical populations.

Research Projects

B01 Context conditioning: Generalization, discrimination, extinction, and the influence of risk factors Pauli, Wieser
B03 The dynamic of fear generalization Büchel
B07 Longitudinal and multimodal investigations of the modulation of fear- and anxiety-related processes by life adversity-predictive and buffering factors
B08 The BDNF system as mediator for stress impaired fear acquisition, extinction and late fear Lange, Andreatta
B09 Stress, fear generalization, and habitual responding Schwabe
B10 The influence and interaction of the dopaminergic and endocannabinoid system on extinction learning mechanisms Haaker