Distinct circuits of the extended amygdala regulating fear generalization and extinction

Pape

The project A03 aims at synaptic circuits of the extended amygdala. Cannabinoid receptors (CB1) regulate GABAergic and glutamatergic synaptic inputs from basal (BA) and central amygdala (CeA) to the bed nucleus of the stria terminalis (BNST; left diagram). These pathways and CB1 regulation of inputs from prefrontal cortex (PFC) are proposed to control fear generalization and extinction, respectively (right diagram).

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