A01: Publications


  1. Kästner N, Richter SH, Urbanik S, Kunert J, Waider J, Lesch KP, Kaiser S, Sachser N (2019)
    Brain serotonin deficiency affects female aggression. Scientific Reports 9: 1366.
  2. Krakenberg V, Woigk I, Garcia Rodriguez L, Kästner N, Kaiser S, Sachser N, Richter SH (2019)
    Technology or ecology? New tools to assess cognitive judgement bias in mice. Behavioural Brain Research, 362, 279-287.


  1. Bodden C, Siestrup S, Palme R, Kaiser S, Sachser N, Richter SH (2018)
    Evidence-based severity assessment: Impact of repeated versus single open-field testing on welfare in C57BL/6J mice. Behavioural Brain Research 336: 261-268.
  2. Kästner N, Richter SH, Bodden C, Palme R, Kaiser S, Sachser N (2018)
    Varying social experiences in adulthood do not differentially affect anxiety-like behavior but stress hormone levels. Frontiers in Behavioral Neurosciences: 12:72.


  1. Bodden C, van den Hove D, Lesch K-P, Sachser N (2017)
    Impact of varying social experiences during life history on behaviour, gene expression, and vasopressin receptor gene methylation in mice. Scientific Reports 7:8719: doi: 10.1038/s41598-017-09292-0.
  2. Kästner N, Richter SH, Gamer M, Kaiser S, Sachser N (2017)
    What a difference a day makes - female behaviour is less predictable near ovulation. Royal Society open science DOI: 10.1098/rsos.160998.
  3. Meyer N, Jenikejew J, Richter SH, Kaiser S, Sachser N (2017)
    Social experiences during adolescence affect anxiety-like behavior but not aggressiveness in male mice. Behavioural Brain Research 326: 147-153.


  1. Graulich DM, Kaiser S, Sachser N, Richter SH (2016)
    Looking on the bright side of bias – validation of an affective bias test for laboratory mice. Applied Animal Behaviour Science, 181, 173–181.
  2. Meyer N, Richter SH, Schreiber RS, Kloke V, Kaiser S, Lesch KP, Sachser N (2016)
    The unexpected effects of beneficial and adverse social experiences during adolescence on anxiety and aggression and its modulation by genotype. Frontiers in Behavioral Neurosciences 10, 97.
  3. Richter SH, Kästner N, Kriwet M, Kaiser S, Sachser N (2016)
    Play matters - the surprising relationship between juvenile playfulness and anxiety in later life. Animal Behaviour 114: 261-271.
  4. Richter SH, Kästner N, Loddenkemper DH, Kaiser S, Sachser N (2016)
    A time to wean? Impact of weaning age on anxiety-like behaviour and stability of behavioural traits in full adulthood. PLoS ONE 11(12): e0167652.
  5. Remmes J, Bodden C, Richter SH, Lesting J, Sachser N, Pape HC, Seidenbecher T (2016)
    Impact of Life History on Fear Memory and Extinction. Front. Behav. Neurosci 10: 185.


  1. Bodden C, Richter SH, Schreiber RS, Kloke V, Gerß J, Palme R, Lesch K-P, Lewejohann L, Kaiser S, Sachser N (2015)
    Benefits of adversity?! How life history affects the behavioural profile of mice varying in serotonin transporter genotype. Front Behav Neurosci 9: 47.
  2. Kästner N, Richter SH, Lesch K-P, Schreiber RS, Kaiser S, Sachser N (2015)
    Benefits of a “vulnerability gene”? A study in serotonin transporter knockout mice. Behav Brain Res 283: 116-120.
  3. Sachser N, Richter SH (2015)
    Animals can tell us more.
    Behavioral and Brain Sciences, 38, 44-45.


  1. Kloke V, Schreiber RS, Bodden C, Möllers J, Ruhmann H, Kaiser S, Lesch K-P, Sachser N, Lewejohann L (2014)
    Hope for the best or prepare for the worst? Towards a spatial cognitive bias test for mice. PLoS One 9: e105431.
  2. Richter SH, Vogel AS, Ueltzhöffer K, Muzzillo C, Vogt MA, Lankisch K, Armbruster-Genc DJN, Riva MA, Fiebach CJ, Gass P, Vollmayr B (2014)
    Touchscreen-paradigm for mice reveals cross-species evidence for an antagonistic relationship of cognitive flexibility and stability. Front Behav Neurosci 8: 154.


  1. Hohof, C, Gorj A, Kaiser S, Willscher E, Korsching E, Ambree O, Arolt V, Lesch KP, Sachser N, Deckert J, Lewejohann L (2013)
    Effect of acute stressor and serotonin transporter genotype on amygdala first wave transcriptome in mice. PLoS ONE 8(3): e58880.
  2. Karabeg MM, Grauthoff S, Kollert SY, Weidner M, Heiming RS, Jansen F, Popp S, Kaiser S, Lesch K-P, Sachser N, Schmitt AG, Lewejohann L (2013)
    5-Htt deficienc affects neuroplasticity and increases stress sensitivity resulting in altered spatial learning performance in the Morris water maze but not in the Barnes maze. PLoS One 8: e78238
  3. Kloke V, Heiming RS, Bölting S, Kaiser S, Lewejohann L, Lesch K-P, Sachser N (2013)
    Unexpected effects of early-life adversity and social enrichment on the anxiety profile of mice varying in serotonin transporter genotype. Behav Brain Res 247: 248-258.
  4. Sachser N, Kaiser S, Hennessy M (2013)
    Behavioural profiles are shaped by social experience: When, how and why.
    Philosophical Transactions of the Royal Society B 368 (1618): doi: 10.1098/rstb.2012.0344


  1. Richter SH, Schick A, Hoyer C, Lankisch K, Gass P, Vollmayr B (2012)
    A glass full of optimism: Enrichment effects on cognitive bias in a rat model of depression. Cog Aff Behav Neurosci 12: 527-542.


  1. Heiming RS, Bodden C, Jansen F, Lewejohann L, Kaiser S, Lesch KP, Palme R, Sachser N (2011)
    Living in a dangerous world decreases maternal care: a study in serotonin transporter knockout mice. Hormones and Behavior: 397-407.
  2. Narayanan V, Heiming RS, Jansen F, Lesting J, Sachser N, Pape H-C, Seidenbecher T (2011)
    Social defeat: impact on fear extinction and amygdala-prefrontal cortical theta synchrony in 5-HTT deficient mice. Plos One 6(7): e22600.
  3. Nietzer SL, Bonn M, Jansen F, Heiming RS, Lewejohann L, Sachser N, Asan ES, Lesch KP, Schmitt AG (2011)
    Serotonin transporter knockout and repeated social defeat stress: impact on neuronal morphology and plasticity in limbic brain areas. Behavioural Brain Research 220: 42-54.
  4. Sachser N, Hennessy MB, Kaiser S (2011)
    Adaptive modulation of behavioural profiles by social stress during early phases of life and adolescence. Neuroscience and Biobehavioural Reviews 35: 1518-1533.


  1. Lewejohann L, Kloke V, Heiming RS, Jansen F, Kaiser S, Schmitt A, Lesch KP, Sachser N (2010)
    Social status and day-to-day behaviour of male serotonin transporter knockout mice.
    Behav Brain Res. 25; 211(2): 220-8.
  2. Sachser N, Kaiser S (2010)
    The social modulation of behavioural development. In: Kappeler P (ed) Animal Behaviour: Evolution and Mechanisms.
    Springer pp 505-536
  3. Dresler T, Ehlis A-C, Heinzel S, Renner TJ, Reif A, Bähne C, Heine M, Boreatti-Hümmer A, Jacob CP, Lesch KP, Fallgatter AJ (2010)
    Dopamine Transporter genotype impacts neurophysiological correlates of cognitive response control in an adult sample of patients with ADHD; in press at Neuropsychopharmacology 
  4. Kriegebaum C, Gutknecht L, Bartke L, Reif A,  Buttenschon AN,  Mors O, Lesch KP, Schmitt A (2010)
    The expression of the transcription factor FEV in adult human brain and its association with affective disorders. Journal of Neural Transmission 117 (7): 831-836 
  5. Kriegebaum C, Gutknecht L, Song NN,  Huang Y, Schmitt A, Reif A, Ding YQ,  Lesch KP (2010) Brain-specific conditional and time-specific inducible Tph2 knockout mice possess normal serotonergic gene expression in the absence of serotonin during adult life. Neurochemistry International 57: 512-517
  6. Laas K, Reif A, Herterich S,  Eensoo D,  Lesch KP,  Harro J (2010)
    The effect of a functional NOS1 promoter polymorphism on impulsivity is moderated by platelet MAO activity; Psychopharmacology 209 (3) 255-261
  7. Landaas ET, Johansson S, Jacobsen KK, Ribasés M, Bosch R, Sánchez-Mora C,  Fernàndez-Castillo N, Bayés M, Casas M,  Jacob CP, Boreatti-Hümmer A,  Heine M, Kreiker S,  Groß-Lesch S, Lesch KP, Kiemeney LA, Kooij JJS, Kan C, Hoogman M,  Buitelaar JK, Faraone SV, Halmøy A, Ramos-Quiroga JA, Cormand B,  Reif A,  Franke B, Mick E, Knappskog PM, Haavik J (2010)
    An international multicenter association study of the serotonin transporter gene in persistent ADHD; Genes, Brain and Behavior 9(5): 449-458
  8. Lazary J, Juhasz G, Anderson I, Jacob CP, Nguyen TT, Lesch KP, Reif A, Deakin JFW,  Bagdy G (2010)
    Epistatic interaction of CREB1 and KCNJ6 on rumination and negative emotionality; in press at European Neuropsychopharmacology
  9. Lesch KP, Selch S, Renner TJ, Jacob CP, Nguyen TT, Hahn T, Romanos M,  Walitza S, Shoichet S, Dempfle A, Heine M, Boreatti-Hümmer A, Romanos J, Gross-Lesch S, Zerlaut H, Wultsch T, Heinzel S, Fassnacht M, Fallgatter AJ,  Allolio B,  Schäfer H, Warnke A, Reif A, Ropers HH, Ullmann R (2010)
    Genome-wide copy number variation analysis in ADHD: association with neuropeptide Y gene dosage in an extended pedigree; in press at Molecular Psychiatry
  10. Reif A, Kiive E, Kurrikoff T, Paaver M, Herterich S, Konstabel K, Tulviste T,  Lesch KP,  Harro J (2010) A functional NOS1 promoter polymorphism interacts with adverse environment on functional and dysfunctional impulsivity; in press at Psychopharmacology
  11. Sánchez-Mora C, Ribasés M, Ramos-Quiroga JA, Casas M, Bosch R, Boreatti-Hümmer A, Heine M, Jacob CP, Lesch KP, Fasmer OB,  Knappskog PM,  Sandra Kooij JJ,  Kan C, Buitelaar JK, Mick E, Asherson P, Faraone SV, Franke B, Johansson S,  Haavik J,  Reif A, Bayés M, Cormand B (2010) Meta-analysis of brain-derived neurotrophic factor p.Val66Met in adult ADHD in four european populations; American Journal of Medical Genetics153B(2): 512-523
  12. Hahn T, Dresler T, Plichta MM, Ehlis AC, Ernst LH, Markulin F, Polak T, Blaimer M, Deckert J, Lesch KP, Jakob PM, Fallgatter AJ (2010)
    Functional Amygdala-Hippocampus Connectivity During Anticipation of Aversive Events is Associated with Gray's Trait "Sensitivity to Punishment". Biol Psychiatry. 68(5) 459-464
  13. Hahn T, Heinzel S, Dresler T, Plichta MM, Renner TJ, Markulin F, Jakob PM, Lesch KP, Fallgatter AJ (2010)
    Association between reward-related activation in the ventral striatum and trait reward sensitivity is moderated by dopamine transporter genotype. in press at Human Brain Mapping.
  14. Sachser N, Hennessy MB, Kaiser S (2010)
    Adaptive modulation of behavioural proilfes by social stress during early phases of live and adolescence. Neuroscience & Biobehavioral. Reviews (in press) (IF = 7.791)
  15. Rivero O, Reif A, Sanjuán J, Moltó MD, Kittel-Schneider S, Nájera C, Töpner T, Lesch KP (2010)
    Impact of the AHI1 gene on the vulnerability to schizophrenia: a case-control association study. PLoS One. 18;5(8):e12254
  16. Heiming RS, Sachser N (2010)
    Consequences of Serotonin Transporter Genotype and Early Adversity on Behavioral Profile – Pathology or Adaptation?. Front. Neurosci. 4:187. doi: 10.3389/fnins.2010.00187
  17. Ehlis AC, Bauernschmitt K, Dresler T, Hahn T, Herrmann MJ, Röser C, Lesch KP, Fallgatter AJ, Renner TJ (2010)
    Influence of a genetic variant of the Neuronal Growth Associated Protein Stathmin 1 on cognitive and affective control processes – An event-related potential study. in press at American Journal of Medical Genetics Part B: Neuropsychiatric Genetics.
  18. Hahn T, Marquand AF, Ehlis AC, Dresler T, Kittel-Schneider S, Jarczok T, Lesch KP, Jakob PM, Mourao-Miranda J, Brammer M, Fallgatter AJ (2010)
    Integrating neurobiological markers of depression. in press at Archives of General Psychiatry.
  19. Hahn T, Heinzel S, Plichta MM, Reif A, Lesch KP, Fallgatter AJ (2010)
    Neurovascular Coupling in the Human Visual Cortex Is Modulated by Cyclooxygenase-1 (COX-1) Gene Variant. in press at Cereb Cortex.


  1. Heiming RS, Jansen F, Lewejohann L, Kaiser S, Schmitt A, Lesch KP,Sachser N (2009)
    Living in a dangerous world: the shaping of behavioral profile by early environment and 5-HTT genotype.
    Front Behav Neurosci.3:26.
  2. Jansen F, Heiming RS, Lewejohann L, Touma C, Palme R, Schmitt A, Lesch KP, Sachser N (2009)
    Modulation of behavioural profile and stress response by 5-HTT genotype and social experience in adulthood.
    Behav Brain Res. 11; 207(1): 21-29. 
  3. Dresler T, Ehlis AC, Plichta MM, Richter MM, Jabs B, Lesch KP, Fallgatter AJ (2009)
    Panic disorder and a possible treatment approach by means of high-frequency r-TMS: A case report. World J Biol Psychiatry  (4 Pt 3):991-997.