A complete list of publications can be found under



Recent examples include

Koltowska, K., Okuda, K.S., Gloger, M., Rondon-Galeano, M., Mason, E.A., Xuan,J., Dudczig, S., Chen, H., Arnold, H., Skoczylas, R., Bower, N.I., Paterson, S., Lagendijk, A.K., Baillie, G.J., Leshchiner,I., Simons, C., Smith, K.A., Goessling, W., Heath, J.K., Pearson, R.B., Sanij, E., Schulte-Merker, S., and Hogan, B. (2021) The RNA helicase Ddx21 controls Vegfc-driven developmental lymphangiogenesis by balancing endothelial cell ribosome biogenesis and p53 function. Nature Cell Biology, in press.

Huisman, Y., Uphoff, K., Berger, M., Dobrindt, U., Schelhaas, M., Zobel, T., Bussmann, J., van Impel, A., Schulte-Merker, S., (2021). Meningeal lymphatic endothelial cells fulfill scavenger endothelial cell function and cooperate with microglia in waste removal from the brain. GLIA, in press.

Suárez, I., Schulte-Merker, S. (2021) Cells with Many Talents: Lymphatic Endothelial Cells in the Brain Meninges, Cells, Apr, 10(4):799 (doi 10.3390/cells10040799).

Mauri, C., van Impel, A., Mackay, E.W., and Schulte-Merker, S. (2021) The adaptor protein Grb2b is an essential modulator for lympho-venous sprout formation. Angiogenesis, Mar, (doi: 10.1007/s10456-021-09774-w).

Silva, J.F., Cross, S., Marriott, A., Pionnier, N., Archer, J., Steven, A., Schulte-Merker, S., Mack, M., Taylor, M.J., and Turner, J.D. (2021). Tetracyclines improve experimental lymphatic filariasis pathology by disrupting interleukin-4 receptor-mediated lymphangiogenesis. JCI, Mar, 1;131(5):e140853 (doi: 10.1172/JCI140853).

Blokzijl-Franke, S., Ponsioen, B., Schulte-Merker, S., Herbomel, P., Kissa, K., Choorapoikayil, S., and den Hertog, J. (2021). Phosphatidylinositol-3 kinase signaling controls survival and stemness of hematopoietic stem and progenitor cells. Oncogene, Mar, (doi: 10.1038/s41388-021-01733-5).

Klems A., van Rijssel J., Ramms A., Wild R., Hinkel R, Suarez-Martinez I., Schulte-Merker S., Vidal R., Sauer S., Kivelä R, Alitalo K., Kupatt C., van Buul J., and le Noble F. (2020). The guanine nucleotide exchange factor Trio controls endothelial cell size and arterial remodeling downstream of Vegf signaling. Nature Communications, Oct, 11(1):5319 (doi: https://doi.org/10.1038/s41467-020-19008-0).

Wang, G., Muhl, L. Padberg, Y., Dupont, L., Peterson-Maduro, J., Stehling, M., Colige, A., le Noble, F., Colige, A., Betsholtz, C., Schulte-Merker, S., and van Impel, A. (2020). Specific Fibroblast subpopulations and neuronal structures serve as local sources of Vegfc-processing components during lymphangiogenesis.Nature Communications, Jun, 11(1):2724 (doi: 10.1038/s41467-020-16552-7).

Yvernogeau, L., Klaus, A., Maas, J., Morin-Poulard, I., Weijts, B., Schulte-Merker, S., Berezikov, E., Junker, J.-P., and Robin, C. (2020). Multispecies RNA tomography reveals Regulators of hematopoietic stem cell birth in the embryonic Aorta. Blood, Aug, 13;136(7):831-844 (doi: 10.1182/blood.2019004446).

Harrison, R.M., Feng, X., Mo, G., Aguayo, A., Villafuerte, J., Yoshida, C., Pearson, C.A., Schulte-Merker, S., and Lien, C.-L. (2019) Late developing cardiac lymphatic vasculature supports adult zebrafish heart function and regeneration. eLife, Nov, 8;8:e42762 (doi: 10.7554/elife.42762).

Kugler, E.C., van Lessen, M., et al., Schulte-Merker, S., Armitage, P., and Chico, T.J.A. (2019) Cerebrovascular endothelial cells form transient Notch-dependnet cystic structures in zebrafish. EMBO Reports, Aug, 20(8):e47047 (doi: 10.15252/embr.201847047).

Camargo-Sosa, K., Colanesi, S., Müller, J., Schulte-Merker, S., Stemple, D., Patton, E.E., and Kelsh, R. (2019) Endothelin receptor Aa regulates proliferation and differentiation of Erb-dependent Pigment progenitors in zebrafish. PLoS Genetics, Feb 27;15(2):e1007941(doi:10.1371/journal.pgen.1007941).

Aleström, P., D'Angelo, L., Midtlyng, P.J., Schorderet, D.F., Schulte-Merker, S., Sohm, F., and Warner, S. (2019) Zebrafish: Housing and husbandry recommendations. Laboratory Animals, Sep, 54(3):213-224 (doi: 10.1177/0023677219869037).

Lleras-Forero, L., Winkler, C., and Schulte-Merker, S. (2019) Zebrafish and medaka as models for biomedical research of bone diseases.  Developmental Biology,Jan, 457(2):191-205 (doi: 10.1016/j.ydbio.2019.07.009).

Eng, T., Chen, W., Okuda, K., Misa, J., Padberg, Y., Croisier, K., Crosier, P., Hall, C., Schulte-Merker, S., Hogan, B., and Austin, J.A. (2019) Zebrafish facial lymphatics develop through sequential addition of venous and non-venous progenitors. EMBO Reports, Mar, 20(5):e47079 (doi: 10.15252/embr.201847079).

Mauri, C., Wang, G. and Schulte-Merker, S. (2018) From fish embryos to human patients: lymphangiogenesis in development and disease. Current Opinions in Immunology, Aug, 53:167-172 (doi: 10.1016/j.coi.2018.05.003).

Lleras Forero, L., Narayanan, R., Huitema, L.F.A., van Bergen, M., Apschner, A., Peterson-Maduro, J., Logister, I., Valentin, G., Morelli, L., Oates, A. and Schulte-Merker, S. (2018) Segmentation of the axial skeleton relies on notochord sheath cells and not on the segmentation clock. eLife, Apr, 7:e33843 (doi: 10.7554/eLife.33843).

Wopat, S, Bagwell, J, Sumigray, KD, Dickson, AL, Huitema, LFA, Poss, KD, Schulte-Merker, S, Bagnat, M (2018) Spine Patterning is Guided by Segmentation of the Notochord Sheath. Cell Reports, Feb, 22(8):2026-2038 (doi: 10.1016/j.celrep.2018.01.084).

Pichol-Thievend, C., Betterman, K.L., Liu, X., Skoczylas, R.,  Lesieur; E.,  Schulte, D., Schulte-Merker, S.,   Hogan, B.M.,  Oliver, G.,  Harvey, N., and Francois, M.  A blood capillary plexus-derived population of progenitor cells contributes to genesis of the dermal lymphatic vasculature during embryonic development. Development, May,145(10):dev160184 (doi:10.1242/dev.160184).

Pogoda, H.-M., Riedl-Quinkertz, I., Löhr, H., Waxman, J.S., Dale, R.M., Topzewski, J., Schulte-Merker, S., and Hammerschmidt, M. (2018). Direct activation of chordoblasts by retinoic acid is required for segmented centra mineralization during zebrafish spine development. Development, May 145(9):dev159418 (doi: 10.1242/dev.159418).

Lopez-Baez, JC, Simpson, DJ, LLeras Forero, L, Zeng, Z, Brunsdon, H, Salzano, A, Brombin, A, Wyatt, C, Rybski, W, Huitema, LFA, Dale, RM, Kawakami, K, Englert, C, Chandra, T, Schulte-Merker, S, Hastie, ND, Patton EE. (2018) Wilms Tumor 1b defines a wound-specific sheath cell Population associated with notochord repair. eLife, Feb, 6;7:e30657 (doi: 10.7554/eLife.30657).

Hogan, B. and Schulte-Merker, S. (2017) How to Plumb a Pisces: Understanding Vascular Development and Disease Using Zebrafish Embryos. Developmental Cell, Sep,42(6):567-583 (doi: 0.1016/j.devcel.2017.08.015).

van Lessen M., Shibata-Germanos S., van Impel A., Hawkins TA., Rihel J., Schulte-Merker S. (2017) Intracellular uptake of macromolecules by brain lymphatic endothelial cells during zebrafish embryoinc development. eLife, May, 6:e25932 (doi: 10.7554/eLife.25932).

Stainier, D.Y.R., Raz, E., Lawson, N.D., Ekker, S.C., Burdine, R.D., Eisen, J.S., Ingham, P.W., Schulte-Merker, S., Yelon, D. et al. (2017) Guidelines for morpholino use in zebrafish. PLoS Genetics, Oct, 13(10):e1007000 (doi: 10.1371/journal.pgen.1007000).

Karpänen, T.K., Padberg, Y., van de Pavert, S.A., Dierkes, C., Morooka, N., Peterson-Maduro, J., van de Hoek, G., Adrian, M., Mochizuki, N., Sekiguchi, K., Kiefer, F., Schulte, D., and Schulte-Merker, S. (2017) An evolutionary conserved role for Polydom/SVEP1during lymphatic vessel Formation. Circulation Research, Apr, 120(8):1263-1275 (doi: 10.1161/CIRCRESAHA.116.308813).

Chiang, I., Fritzsche, M., Pichol-Thievend, C., Neal, A., Holmes, K., Lagendijk, A., Overman, J., D'Angelo, D., Omini, A., Hermkens, D, Lesieur, E., Liu, K., Ratnayaka, I., Corada, M., Bou-Gharios, G., Caroll, J., Dejana, E., Schulte-Merker, S., Hogan, B., Beltrame, M., De Val, S., and Fancois, M. (2017) SoxF factors induce Notch1 expression via direct transcriptional regulation during early arterial development. Development, Jul144 (14):2629-2639 (doi: 10.1242/dev.146241) .

Wild, R., Klems, A., Takamiya, M., Hayashi, Y., Strähle, U., Ando, K., Mochizuki, N., van Impel, A., Schulte-Merker, S., Krueger, J., Preau, L., and le Noble, F. (2017) Neuronal sFlt1 and Vegfaa determine venous sprouting and spinal cord vascularization. Nature Communications, Jan, 10;8:13991 (doi: 10.1038/ncomms13991).

Roukens MG, Peterson-Maduro J, Padberg Y, Jeltsch M, Leppänen VM, Bos FL, Alitalo K, Schulte-Merker, S., Schulte D. (2015) Functional Dissection of the CCBE1 Protein: A Crucial Requirement for the Collagen Repeat Domain. Circulation Research, Mar, 116(10):1660-9 (doi: 10.1161/CIRCRESAHA.116.304949).

van Impel, A., Zhao, Z., Hermkens, D.M.A., Roukens, G., Fischer, J.C., Peterson-Maduro, J., Duckers, H., Ober, E.A., Ingham, P.W., and Schulte-Merker, S. (2014) Divergence of lymphatic cell specification pathways between zebrafish and mice. Development, Mar, 141(6):1228-1238 (doi: 10.1242%2Fdev.105031).

Gordon, K., Schulte, D., et al ...., Schulte-Merker, S., and Ostergaard, P. (2013) A mutation in VEGFC, a ligand for VEGFR3, is associated with autosomal-dominant Milroy-like primary lymphedema. Circulation Research, Feb, 112(6):956-60 (doi:10.1161/CIRCRESAHA.113.300350)

Huitema LF, Apschner A, Logister I, Spoorendonk KM, Bussmann J, Hammond CL, Schulte-Merker S. (2012) Entpd5 is essential for skeletal mineralization and regulates phosphate homeostasis in zebrafish. PNAS, Dec, 109(52):21372-77 (doi: 10.1073%2Fpnas.1214231110).

Bos, F.L., Caunt, M., et al., and Schulte-Merker, S. (2011) CCBE1 Is Essential for Mammalian Lymphatic Vascular Development and Enhances the Lymphangiogneic Effect of Vascular Endothelial Growth Factor-C In Vivo. Circulation Research, Jul, 109(5): 486-91 (doi: 10.1161/CIRCRESAHA.111.250738).

Schulte-Merker, S., Sabine, A., and Petrova, T. (2011). Lymphatic vascular morphogenesis in development, physiology, and disease. Journal of Cell Biology, May, 193(4):607-618 (doi: 10.1083%2Fjcb.201012094).

Hogan, B.M., Bos, F., Bussmann, J., Witte, M., Chi, N., Duckers, H., Schulte-Merker, S. (2009) Ccbe1 is required for embryonic lymphangiogenesis and venous sprouting. Nature Genetics, Mar, 41:396-398 (doi: 10.1038/ng.321).

Alders, M., Hogan, B.M., Gjini, E., Salehi, F., Al-Gazali, L., Hennekam, E.A., Holmberg, E.E., Mannens, M.M.A.M., Mulder, M.F., Offerhaus, G.J.A., Prescott, T.E., Schroor, E.J., Verheij, J.B.G.M., Witte, M., Zwijnenburg, P.J., Vikkula, M., Schulte-Merker, S. & Hennekam, R.C. (2009) Mutations in CCBE1 cause generalized lymph vessel dysplasia in humans. Nature Genetics, Nov, 41:1272-1274 (doi:10.1038/ng.484).

Spoorendonk, K., Peterson-Maduro, J., Renn, J., Trowe, T., Kranenbarg, S., Winkler, C., Schulte-Merker, S. (2008) Retinoic Acid and Cyp26b1 are critical regulators of osteogenesis in the axial skeleton. Development, Nov, 135:3765-3774 (doi: 10.1242/dev.024034).

Küchler, A.M., Gjini, E., Peterson-Maduro, J., Cancilla, B., Wolburg, H., Schulte-Merker, S. (2006). Development of the zebrafish lymphatic system requires Vegfc signaling. Current Biology, Jun, 16:1244-1248 (doi: 10.1016/j.cub.2006.05.026).