Experimental Animal StudiesThe aim of the experimental animal studies is to identify crucial mechanisms of the interplay between genetic, environmental and neurobiological systems, which form the basis of anxiety traits, thereby providing a reasonable basis for explanation of data from and providing input into complementary human studies.

Research Projects

A01 Life history, serotonin transporter genotype and anxiety-like behaviour: testing the “coping-with-challenge hypothesis”
Sachser, Richter, Lesch,
A02 Contribution of CRF and 5-HT in the anterodorsal BNST to phasic and sustained fear in freely behaving mice Seidenbecher
A03 Distinct circuits of the extended amygdala regulating fear generalization and extinction Pape
A04 Cell type-specificity of endocannabinoid signaling in amygdala-BNST projections regulating sustained fear Lutz, Pape
A05 Stress-induced programming in serotonin (5-HT) system-modified mice: epigenetic editing as a strategy to cope with anxiety van den Hove, Lesch, Schmitt-Böhrer
A08 Impact of the Neuropeptide S system and NPS-receptor polymorphisms on fear and anxiety Jüngling
A10 Role of hippocampal BDNF signaling in contextual fear learning, fear generalization and context discrimination Blum, Sendtner