SFB 1009 Breaking Barriers Publications

The principal investigators are highlighted in bold.

  • General publication of the SFB 1009

    Members of the Breaking Barriers research team, Germany, Principal Investigators Professor Cornelius Faber, Dr. Bettina Löffler, and Professor Georg Peters describe their research, the importance of understanding pathogen-host interactions on a cellular scale and their ambition to use this knowledge to create new clinical interventions.

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    (Format: PDF, Adobe Reader). 

    Pushing the barriers of knowledge, International Innovation, Regional Research, Issue September 2013, pages 86-88

  • Reviews of the SFB 1009


    • Eble JA, Niland S (2019) The extracellular matrix in tumor progression and metastasis. Clin Exp Metastasis 36: 171-198
    • Hannocks MJ, Zhang X, Gerwien H, Chashchina A, Burmeister M, Korpos E, Song J, Sorokin L (2019) The gelatinases, MMP-2 and MMP-9, as fine tuners of neuroinflammatory processes. Matrix Biol 75-76: 102-113
    • Ludwig S, Hrincius ER, Boergeling Y (2019) The Two Sides of the Same Coin-Influenza Virus and Intracellular Signal Transduction. Cold Spring Harb Perspect Med pii: a038513.
    • Niland S, Eble JA (2019) Neuropilins in the Context of Tumor Vasculature. Int J Mol Sci 20
    • Raabe CA, Groper J, Rescher U (2019) Biased perspectives on formyl peptide receptors. Biochim Biophys Acta Mol Cell Res 1866: 305-316
    • Scheu S, Ali S, Mann-Nuttel R, Richter L, Arolt V, Dannlowski U, Kuhlmann T, Klotz L, Alferink J (2019) Interferon beta-Mediated Protective Functions of Microglia in Central Nervous System Autoimmunity. Int J Mol Sci 20
    • Yildirim K, Petri J, Kottmeier R, Klämbt C (2019) Drosophila glia: Few cell types and many conserved functions. Glia 67: 5-26


    • Albers F, Wachsmuth L, van Alst TM, Faber C (2018) Multimodal Functional Neuroimaging by Simultaneous BOLD fMRI and Fiber-Optic Calcium Recordings and Optogenetic Control. Mol Imaging Biol 20: 171-182
    • Austermann J, Spiekermann C, Roth J (2018) S100 proteins in rheumatic diseases. Nat Rev Rheumatol 14: 528-541
    • Eble JA, Estevao-Costa MI, Niland S, Sanchez EOF (2018) Venoms versus vasculature and hemostasis: in search for non-hemorrhagic anti-hemostatic venom components. Clin Cell Immunol 9
    • Holthenrich A, Gerke V (2018) Regulation of von-Willebrand Factor Secretion from Endothelial Cells by the Annexin A2-S100A10 Complex. Int J Mol Sci 19 19(6). pii: E1752
    • Kampmeier S, Berger M, Mellmann A, Karch H, Berger P (2018) The 2011 German Enterohemorrhagic Escherichia Coli O104:H4 Outbreak-The Danger Is Still Out There. Curr Top Microbiol Immunol 416: 117-148
    • Klemm C, Boergeling Y, Ludwig S, Ehrhardt C (2018) Immunomodulatory Nonstructural Proteins of Influenza A Viruses. Trends Microbiol 26: 624-636
    • Lindner M, Klotz L, Wiendl H (2018) Mechanisms underlying lesion development and lesion distribution in CNS autoimmunity. J Neurochem 146: 122-132
    • Norkowski S, Schmidt MA, Rüter C (2018) The species-spanning family of LPX-motif harbouring effector proteins. Cell Microbiol 20: e12945
    • Schloer S, Pajonczyk D, Rescher U (2018) Annexins in Translational Research: Hidden Treasures to Be Found. Int J Mol Sci19(6). pii: E1781


    • Cavaco A, Rezaei M, Niland S, Eble JA (2017) Collateral Damage Intended-Cancer-Associated Fibroblasts and Vasculature Are Potential Targets in Cancer Therapy. Int J Mol Sci 18
    • Grabowski B, Schmidt MA, Rüter C (2017) Immunomodulatory Yersinia outer proteins (Yops)-useful tools for bacteria and humans alike. Virulence 8: 1124-1147
    • Masemann D, Boergeling Y, Ludwig S (2017) Employing RNA viruses to fight cancer: novel insights into oncolytic virotherapy. Biol Chem 398: 891-909
    • Stadtmann A, Zarbock A (2017) The role of kindlin in neutrophil recruitment to inflammatory sites. Curr Opin Hematol 24: 38-45
    • Rüter C, Schmidt MA (2017) Cell-Penetrating Bacterial Effector Proteins: Better Tools than Targets. Trends Biotechnol 35: 109-120


    • Dobrindt U, Wullt B, Svanborg C (2016) Asymtomatic Bacteriuria as a Model to Study the Coevolution of Hosts and Bacteria. Pathogens 5(1). pii: E21
    • Goswami D, Vestweber D (2016) How leukocytes trigger opening and sealing of gaps in the endothelial barrier. F1000Res 5. pii: F1000 Faculty Rev-2321.
    • Fennen M, Pap T, Dankbar B (2016) Smad-dependent mechanisms of inflammatory bone destruction. Arthritis Res Ther 18: 279
    • Schirmeier S, Matzat T, Klämbt C (2016) Axon ensheathment and metabolic supply by glial cells in Drosophila. Brain Res 1641: 122-129


    • Dobrindt U, Tjaden S, Shah S, Hacker J (2015b) Mobile genetic elements and pathogenicity islands encoding bacterial toxins. In: The Comprehensive Sourcebook of Bacterial Protein Toxins (Alouf, J., Ladant, D., Popoff, M. eds.) Elsevier Amsterdam, 40-76.
    • Vestweber D (2015) How leukocytes cross the vascular endothelium. Nat Rev Immunol 15: 692-704.


    • Bogdani, M., Korpos, E., Simeonovic, C. J., Sorokin, L. and Wright, T. N. (2014). Extracellular matrix components in the pathogenesis of type 1 diabetes. Curr Diab Rep 14: 552-564.
    • Schoofs T, Berdel WE, Müller-Tidow C (2014) Origins of aberrant DNA methylation in acute myeloid leukemia. Leukemia 28: 1–14.


    • Wiendl H, Gross CC (2013) Modulation of IL-2Rα with daclizumab for treatment of multiple sclerosis. Nature Rev Neurol 9: 394-404.
  • Publications 2021

    Ambite I, Filenko NA, Zaldastanishvili E, Butler DS, Tran TH, Chaudhuri A, Esmaeili P, Ahmadi S, Paul S, Wullt B, Putze J, Chen SL, Dobrindt U, Svanborg C (2021) Active bacterial modification of the host environment through RNA polymerase II inhibition. J Clin Invest 131(4):e140333

    Ashraf A, Gerke V (2021) Plasma membrane wound repair is characterized by extensive membrane lipid and protein rearrangements in vascular endothelial cells. BBA Mol Cell Res 1868: 118991

    Bielaszewska M, Greune L, Bauwens A, Dersch P, Mellmann ARüter C (2021) Virulence Factor Cargo and Host Cell Interactions of Shiga Toxin-Producing Escherichia coli Outer Membrane Vesicles. Methods Mol Biol 2291:177-205

    Butler DSC, Cafaro C, Putze J, Wan MLY, Tran TH, Ambite I, Ahmadi S, Kjellström S, Welinder C, Chao SM, Dobrindt U, Svanborg C (2021) A bacterial protease depletes c-MYC and increases survival in mouse models of bladder and colon cancer. Nat Biotechnol. doi: 10.1038/s41587-020-00805-3

    Chaoprasid P, Lukat P, Mühlen S, Heidler T, Gazdag EM, Dong S, Bi W, Rüter C, Kirchenwitz M, Steffen A, Jänsch L, Stradal T, Dersch P, Wulf Blankenfeldt W (2021) Crystal structure of full-length cytotoxic necrotizing factor CNFY reveals molecular building blocks for intoxication. EMBO J 7:e105202

    Christmann C, Zenker S, Martens L, Hübner J, Loser K, Vogl T,Roth J (2021) Interleukin 17 promotes expression of alarmins S100A8 and S100A9 during the inflammatory response of keratinocytes. Front Immun 11: 599947

    Hertenstein H, McMullen E, Weiler A, Volkenhoff A, Becker HM, Schirmeier S (2021) Starvation-induced regulation of carbohydrate transport at the blood-brain barrier is TGF-β-signaling dependent. eLife. Accepted

    Isasti-Sanchez J, Münz-Zeise F, Lancino M, Luschnig S (2021) Transient opening of tricellular vertices controls paracellular transport through the follicle epithelium during Drosophila oogenesis. Dev Cell 56, P1083–1099.e5

    McMullen E, Weiler A, Becker HM, Schirmeier (2021) Plasticity of Carbohydrate Transport at the Blood-Brain Barrier. Front. Behav. Neurosci. 14: 271

    Meissner J, Rezaei M, Siepe I, Ackermann D, König S, Eble JA(2021) Redox proteomics reveals an interdependence of redox modification and location of adhesome proteins in NGF-treated PC12 cells. Free radical biology & medicine 164: 341-353, 10.1016/j.freeradbiomed

    Pirr S, Dauter L, Vogl T, Ulas T, Bohnhorst B, Roth J, Viemann D (2021) S100A8/A9 is the first predictive marker for neonatal sepsis.Clin Transl Med 11(4):e338

    Sanchez EF, Alvarenga VG, Oliveira LS, Oliveira DL, Estevao-Costa MI, Flores-Ortiz R, Eble JA (2021) A fibrinolytic snake venom metalloproteinase, mutalysin-II, with antiplatelet activity and targeting capability toward glycoprotein GPIbalpha and glycoprotein GPVI. Biochimie 10.1016/j.biochi

    Stahl LS, Roth J, Rudack C, McNally A, Weber J, Vogl T, Spiekermann C (2021) Evaluation of the QUANTUM BLUE sCAL rapid test as a point of care tool to identify patients with peritonsillar abscess. Sci Rep 11(1):4497

  • Publications 2020

    Arce-Molina R, Cortés-Molina F, Sandoval PY, Galaz A, Alegría K, Schirmeier S, Barros LF, San Martín A (2020) A highly responsive pyruvate sensor reveals pathway-regulatory role of the mitochondrial pyruvate carrier MPC. Elife 9: e53917

    Arif N, Zinnhardt M, Nyamay’Antu A, Teber D, Brückner R, Schäfer K, Li Y-T, Trappmann B, Grashoff C, Vestweber D (2020) PECAM-1 supports diapedesis by tension-dependent dephosphorylation of VE-cadherin. EMBO J 3;40(9): e106113

    Bano L, Kiel M, Sales G, Doxey AC, Mansfield MJ, Wami HT, Schiavone M, Rossetto O, Pirazzini M, Dobrindt U, Montecucco C (2020) Genome Sequence of the Fish Brain Bacterium Clostridium tarantellae. Microbiol Resour Announc 9(16):e01575-19

    Bayraktar S, Nehrig J, Menis E, Karli K, Janning A, Struk T, Halbritter J, Michgehl U, Krahn MP, Schuberth CE, Pavenstädt H, Wedlich-Söldner R (2020) A Deregulated Stress Response Underlies Distinct INF2-Associated Disease Profiles. J Am Soc Nephrol 31(6):1296-1313

    Bergerhausen L, Grosche J, Meissner J, Hecker C, Caliandro MF, Westerhausen C, Kamenac A, Rezaei M, Morgelin M, Poschmann G, Vestweber D, Hanschmann EM, Eble JA(2020) Extracellular Redox Regulation of a7b1 Integrin-Mediated Cell Migration Is Signaled via a Dominant Thiol-Switch. Antioxidants (Basel) 9 10.3390/antiox9030227

    Bielaszewska M, Daniel O, Karch- H, Mellmann A (2020) Dissemination of the blaCTX-M-15 gene among Enterobacteriaceae via outer membrane vesicles. The Journal of antimicrobial chemotherapy 75(9), 2442–2451

    Boltersdorf T, Ansari J, Senchenkova EY, Groeper J, Pajonczyk D, Vital SA, Kaur G, Alexander JS, Vogl T, Rescher U, Long NJ, Gavins FNE (2020) Targeting of Formyl Peptide Receptor 2 for in vivo imaging of acute vascular inflammation. Theranostics 10, 6599-6614

    Braun LJ, Stegmeyer R, Schäfer K, Volkery S, Currie SM, Kempe B, Nottebaum AF, Vestweber D (2020) Platelets docking to VWF prevent leaks during leukocyte extravasation by stimulating Tie-2. Blood 136(5): 627-639

    Detzner J, Gloerfeld C, Pohlentz G, Legros N, Humpf HU, Mellmann A, Karch H, Müthing J (2019) Structural Insights into Escherichia coli Shiga Toxin (Stx) Glycosphingolipid Receptors of Porcine Renal Epithelial Cells and Inhibition of Stx-Mediated Cellular Injury Using Neoglycolipid-Spiked Glycovesicles. Microorganisms 7(11), 582

    Detzner J, Steil D, Pohlentz G, Legros N, Humpf HU, Mellmann A, Karch H, Müthing J (2020) Real-time interaction analysis of Shiga toxins and membrane microdomains of primary human brain microvascular endothelial cells. Glycobiology. doi: 10.1093/glycob/cwz091

    Fischer-Riepe L, Daber NM, Schulte-Schrepping J, Veras de Cavalho BC, Russo A, Pohlen M, Fischer J, Chasan AI, Wolf M, Ulas T, Glander S, Schulz C, Skryabin B, Wollbrink A, Steingraeber N, Stemmel C, Koehler M, Gärtner F, Vettorazzi S, Holzinger D, Gross J, Rosenbauer F, Stoll M, Niemann S, Tuckermann J, Schultze JL, Roth J, Barczyk-Kahlert K. (2020) CD163 expression defines specific, IRF8-dependent, immune-modulatory macrophages in the bone marrow. J. Allergy Clin. Immunol 146, 1151

    Gati NS, Middendorf-Bauchart B, Bletz S, Dobrindt U, Mellmann A (2019) Origin and Evolution of Hybrid Shiga Toxin-Producing and Uropathogenic Escherichia coli Strains of Sequence Type 141. Journal of clinical microbiology 58(1), e01309-19

    Frohberger SJ, Fercoq F, Neumann AL, Surendar J, Stamminger W, Ehrens A, Karunakaran I, Remion E, Vogl T, Hoerauf A, Martin C, Hübner MP (2020) S100A8/S100A9 deficiency increases neutrophil activation and protective immune responses against invading infective L3 larvae of the filarial nematode Litomosoides sigmodontis. PLoS Negl Trop Dis 27;14(2):e0008119

    Hallmann R, Hannocks M-J, Song J, Zhang X, Di Russo J, Luik A-L, Burmeister M, Gerwien H, Sorokin L. (2020) The role of basement membrane laminins in vascular function. Int. J. Biochem. Cell Biol 105823

    Kalsy M, Tonk M, Hardt M, Dobrindt U, Zdybicka-Barabas A, Cytrynska M, Vilcinskas A, Mukherjee K (2020) The insect antimicrobial peptide cecropin A disrupts uropathogenic Escherichia coli biofilms. NPJ Biofilms Microbiomes 6(1):6

    Kehl A, Kuhn R, Detzner J, Steil D, Müthing J, Karch H, Mellmann A (2020) Modeling Native EHEC Outer Membrane Vesicles by Creating Synthetic Surrogates. Microorganisms 8(5), 673

    Kouzel IU, Kehl A, Berger P, Liashkovich I, Steil D, Makalowski W, Suzuki Y, Pohlentz G, Karch H, Mellmann A, Müthing J (2020) RAB5A and TRAPPC6B are novel targets for Shiga toxin 2a inactivation in kidney epithelial cells. Sci Rep 18;10(1):4945

    Leite Dantas R, Bettenworth D, Varga G, Weinhage T, Wami HT, Dobrindt U, Roth J, Vogl T, Ludwig S, Wixler V. (2020) Spontaneous onset of TNFα-triggered colonic inflammation depends on functional T lymphocytes, S100A8/A9 alarmins, and MHC H-2 haplotype. J Pathol 251(4):388-399

    Li G, Nottebaum AF, Brigell M, Nevaro ID, Ipe U, Soldo B, Pakola S, Peters KG, Vestweber D, Stamer D (2020) A small molecule Tie2 activator, AKB-9778, reduces intraocular pressure by targeting VE-PTP in Schlemm’s Canal. Invest Ophtalmol Vis Sci 61(14):12

    Li L, Song J, Chuquisana O, Hannocks MJ, Loismann S, Vogl T, Roth J, Hallmann R, Sorokin L (2020) Endothelial Basement Membrane Laminins as an Environmental Cue in Monocyte Differentiation to Macrophages. Front Immunol 11:584229

    Lindemann O, Rossaint J, Najder K, Schimmelpfennig S, Hofschröer V, Wälte M, Fels B, Oberleithner H, Zarbock A, Schwab A (2020) Intravascular adhesion and recruitment of neutrophils in response to CXCL1 depends on their TRPC6 channels. J Mol Med (Berl) 98(3):349-360

    Margraf A, Cappenberg A, Vadillo E, Ludwig N, Thomas K, Körner K, Zondler L, Rossaint J, Germena G, Hirsch E, Zarbock A (2020) ArhGAP15, a RacGAP, Acts as a Temporal Signaling Regulator of Mac-1 Affinity in Sterile Inflammation. J Immunol 1;205(5):1365-1375

    Margraf A, Germena G, Drexler HCA, Rossaint J, Ludwig N, Prystaj B, Mersmann S, Thomas K, Block H, Gottschlich W, Liu C, Krenn PW, Haller H, Heitplatz B, Meyer Zu Brickwedde M, Moser M, Vestweber D, Zarbock A (2020) The integrin-linked kinase is required for chemokine-triggered high-affinity conformation of the neutrophil β2-integrin LFA-1. Blood 5;136(19):2200-2205

    Martin B, Schepmann D, Bernal FA, Schmidt TJ, Che T, Loser K, Wünsch B (2020) Enantiomerically Pure Quinoline-Based κ-Opioid Receptor Agonists: Chemoenzymatic Synthesis and Pharmacological Evaluation. ChemMedChem 5;15(15):1408-1420

    Mukherjee K, Amsel D, Kalsy M, Billion A, Dobrindt U, Vilcinskas A (2020) MicroRNAs regulate innate immunity against uropathogenic and commensal-like Escherichia coli infections in the surrogate insect model Galleria mellonella. Sci Rep 10(1):2570

    Niland S, Eble JA (2020) Hold on or Cut? Integrin- and MMP-Mediated Cell-Matrix Interactions in the Tumor Microenvironment. Int J Mol Sci 22(1):238

    Niland S, Eble JA (2020) Neuropilin: Handyman and Power Broker in the Tumor Microenvironment. Adv Exp Med Biol 1223: 31-67,  10.1007/978-3-030-35582-1_3

    Park H, Yamamoto H, Mohn L, Ambühl L, Kanai K, Schmidt I, Kim KP, Fraccaroli A, Feil S, Junge HJ, Montanez E, Berger W, Adams RH (2019) Integrin-linked kinase controls retinal angiogenesis and is linked to Wnt signaling and exudative vitreoretinopathy. Nat Commun 10:5243

    Raker VK, Becker C, Landfester K, Steinbrink K (2020) Targeted Activation of T Cells with IL-2-Coupled Nanoparticles. Cells 9;9(9):2063

    Rezaei M, Martins Cavaco AC, Stehling M, Nottebaum A, Brockhaus K, Caliandro MF, Schelhaas S, Schmalbein F, Vestweber D, Eble JA (2020) Extracellular Vesicle Transfer from Endothelial Cells Drives VE-Cadherin Expression in Breast Cancer Cells, Thereby Causing Heterotypic Cell Contacts. Cancers (Basel) 12(8):2138

    Rüter C, Bielaszewska M (2020) Secretion and Delivery of Intestinal Pathogenic Escherichia coli Virulence Factors via Outer Membrane Vesicles. Front Cell Infect Microbiol 10: 91

    Scott NR, Swanson RV, Al-Hammadi N, Domingo-Gonzalez R, Rangel-Moreno J, Kriel BA, Bucsan AN, Das S, Ahmed M, Mehra S, Treerat P, Cruz-Lagunas A, Jimenez-Alvarez L, Muñoz-Torrico M, Bobadilla-Lozoya K, Vogl T, Walzl G, du Plessis N, Kaushal D, Scriba T, Zuñiga J,  Khader S (2020) S100A8/A9 regulates CD11b expression and neutrophil recruitment during chronic tuberculosis. J. Clin. Invest. 2020 Mar 5. pii: 130546

    Seethaler A, Stenner M, McNally A, Rudack C, Roth J, Vogl T, Spiekermann C (2020)  IL-8 and IFN-γ as Preoperative Predictors of the Outcome of Tonsillectomy. Ear Nose Throat J 17:145561320910682

    Skryabin BV, Kummerfeld DM, Gubar L, Seeger B, Kaiser H, Stegemann A, Roth J, Meuth SG, Pavenstädt H, Sherwood J, Pap T, Wedlich-Söldner R, Sunderkötter C, Schwartz YB, Brosius J, Rozhdestvensky TS (2020) Pervasive head-to-tail insertions of DNA templates mask desired CRISPR-Cas9-mediated genome editing events. Sci Adv. 6(7):eaax2941. doi: 10.1126/sciadv.aax2941

    Stegemann A, Flis D, Ziolkowski W, Distler JHW, Steinbrink K, Böhm M (2020) The α7 Nicotinic Acetylcholine Receptor: A Promising Target for the Treatment of Fibrotic Skin Disorders. J Invest Dermatol 140(12):2371-2379

    Weishaupt C, Goerge T, Loser K (2020) Activated melanoma vessels: A sticky point for successful immunotherapy. Exp Dermatol (11):1046-1054

    Willers M, Ulas T, Völlger L, Vogl T, Heinemann AS, Pirr S, Pagel J, Fehlhaber B, Halle O, Schöning J, Schreek S, Löber U, Essex M, Hombach P, Graspeuntner S, Basic M, Bleich A, Cloppenborg-Schmidt K, Künzel S, Jonigk D, Rupp J, Hansen G, Förster R, Baines JF, Härtel C, Schultze JL, Forslund SK, Roth J, Viemann D (2020) S100A8 and S100A9 are Important for Postnatal Development of Gut Microbiota and Immune System in Mice and Infants. Gastroenterology 14:S0016-5085(20)35058-7. doi: 10.1053/j.gastro.2020.08.019. Online ahead of print

    Wittek A, Hollmann M, Schleutker R, Luschnig S. (2020) The Transmembrane Proteins M6 and Anakonda Cooperate to Initiate Tricellular Junction Assembly in Epithelia of Drosophila. Curr Biol 30(21):4254-4262.e5

  • Publications 2019

    Abo Basha J, Kiel M, Gorlich D, Schutte-Nutgen K, Witten A, Pavenstädt H, Kahl BC, Dobrindt U, Reuter S (2019) Phenotypic and Genotypic Characterization of Escherichia coli Causing Urinary Tract Infections in Kidney-Transplanted Patients. In J Clin Med 8(7). pii: E988

    Albers F, Wachsmuth L, Schache D, Lambers H, Faber C (2019) Functional MRI Readouts From BOLD and Diffusion Measurements Differentially Respond to Optogenetic Activation and Tissue Heating. Front Neurosci 13: 1104

    Ambite I, Butler DSC, Stork C, Gronberg-Hernandez J, Koves B, Zdziarski J, Pinkner J, Hultgren SJ, Dobrindt U, Wullt B, Svanborg C (2019) Fimbriae reprogram host gene expression - Divergent effects of P and type 1 fimbriae. PLoS Pathog 15: e1007671

    Baturcam E, Vollmer S, Schluter H, Maciewicz RA, Kurian N, Vaarala O, Ludwig S, Cunoosamy DM (2019) MEK inhibition drives anti-viral defence in RV but not RSV challenged human airway epithelial cells through AKT/p70S6K/4E-BP1 signalling. Cell Commun Signal 17: 78

    Berger M, Aijaz I, Berger P, Dobrindt U, Koudelka G (2019) Transcriptional and Translational Inhibitors Block SOS Response and Shiga Toxin Expression in Enterohemorrhagic Escherichia coli. Sci Rep 9: 18777

    Berger P, Kouzel IU, Berger M, Haarmann N, Dobrindt U, Koudelka GB, Mellmann A (2019) Carriage of Shiga toxin phage profoundly affects Escherichia coli gene expression and carbon source utilization. BMC Genomics 20: 504

    Beydokhti SS, Stork C, Dobrindt U, Hensel A (2019) Orthosipon stamineus extract exerts inhibition of bacterial adhesion and chaperon-usher system of uropathogenic Escherichia coli-a transcriptomic study. Appl Microbiol Biotechnol 103: 8571-8584

    Braun LJ, Zinnhardt M, Vockel M, Drexler HC, Peters K, Vestweber D (2019) VE-PTP inhibition stabilizes endothelial junctions by activating FGD5. EMBO Rep 20: e47046

    Cappenberg A, Margraf A, Thomas K, Bardel B, McCreedy DA, Van Marck V, Mellmann A, Lowell CA, Zarbock A (2019) L-selectin shedding affects bacterial clearance in the lung: a new regulatory pathway for integrin outside-in signaling. Blood 134: 1445-1457

    Caviglia S, Flores-Benitez D, Lattner J, Luschnig S, Brankatschk M (2019) Rabs on the fly: Functions of Rab GTPases during development. Small GTPases 10: 89-98

    Detzner J, Gloerfeld C, Pohlentz G, Legros N, Humpf HU, Mellmann A, Karch H, Müthing J (2019a) Structural Insights into  Escherichia coli Shiga Toxin (Stx) Glycosphingolipid Receptors of Porcine Renal Epithelial Cells and Inhibition of Stx-Mediated Cellular Injury Using Neoglycolipid-Spiked Glycovesicles. Microorganisms 7 (11). pii: E582

    Detzner J, Steil D, Pohlentz G, Legros N, Humpf HU, Mellmann A, Karch H, Müthing J (2019) Real- time interaction analysis of Shiga toxins and membrane microdomains of primary human brain microvascular endothelial cells. Glycobiology pii: cwz091

    Dlugos CP, Picciotto C, Lepa C, Krakow M, Stober A, Eddy ML, Weide T, Jeibmann A, M PK, Van Marck V, Klingauf J, Ricker A, Wedlich-Soldner R, Pavenstädt H, Klämbt C, George B (2019) Nephrin Signaling Results in Integrin beta1 Activation. J Am Soc Nephrol 30: 1006-1019

    Freise N, Burghard A, Ortkras T, Daber N, Imam Chasan A, Jauch SL, Fehler O, Hillebrand J, Schakaki M, Rojas J, Grimbacher B, Vogl T, Hoffmeier A, Martens S, Roth J, Austermann J (2019) Signaling mechanisms inducing hyporesponsiveness of phagocytes during systemic inflammation. Blood 134: 134-146

    Galstyan A, Dobrindt U (2019) Determining and unravelling origins of reduced photoinactivation efficacy of bacteria in milk. J Photochem Photobiol B 197: 111554

    Galstyan A, Ricker A, Nüsse H, Klingauf J, Dobrindt U (2019) Exploring the impact of coordination-driven self assembly on the antibacterial activity of low-symmetry phthalocyanines. ACS Appl Bio Mater

    Gati NS, Middendorf-Bauchart B, Bletz S, Dobrindt U, Mellmann A (2019) Origin and Evolution of Hybrid Shiga Toxin-Producing and Uropathogenic Escherichia coli Strains of Sequence Type 141. J Clin Microbiol 58(1). pii: e01309-19

    Gross CC, Meyer C, Bhatia U, Yshii L, Kleffner I, Bauer J, Tröscher AR, Schulte-Mecklenbeck A, Herich S, Schneider-Hohendorf T, Plate H, Kuhlmann T, Schwaninger M, Brück W, Pawlitzki M, Laplaud DA, Loussouarn D, Parratt J, Barnett M, Buckland ME, Hardy TA, Reddel SW, Ringelstein M, Dörr J, Wildemann B, Kraemer M, Lassmann H, Höftberger R, Beltrán E, Dornmair K, Schwab N, Klotz L, Meuth SG, Martin-Blondel G, Wiendl H, Liblau R. CD8+ T cell-mediated endotheliopathy is a targetable mechanism of neuro-inflammation in Susac syndrome. Nat Commun 10(1):5779.

    Helfen A, Grosse Hokamp N, Geyer C, Heindel W, Bremer C, Vogl T, Holtke C, Masthoff M, Barczyk-Kahlert K, Roth J, Wildgruber M, Eisenblaetter M (2019) Target-Specific Imaging of Cathepsin and S100A8/A9 Reflects Specific Features of Malignancy and Enables Estimation of Tumor Malignancy. Mol Imaging Biol

    Holthenrich A, Drexler HCA, Chehab T, Nass J, Gerke V (2019) Proximity proteomics of endothelial Weibel-Palade bodies identifies novel regulator of von Willebrand factor secretion. Blood 134: 979-982

    Klotz L, Eschborn M, Lindner M, Liebmann M, Herold M, Janoschka C, Torres Garrido B, Schulte-Mecklenbeck A, Gross CC, Breuer J, Hundehege P, Posevitz V, Pignolet B, Nebel G, Glander S, Freise N, Austermann J, Wirth T, Campbell GR, Schneider-Hohendorf T, Eveslage M, Brassat D, Schwab N, Loser K, Roth J, Busch KB, Stoll M, Mahad DJ, Meuth SG, Turner T, Bar-Or A & Wiendl H. (2019) Teriflunomide treatment for multiple sclerosis modulates T cell mitochondrial respiration with affinity-dependent effects. Sci Transl Med 11(490). pii: eaao5563.

    Legros N, Ptascheck S, Pohlentz G, Karch H, Dobrindt U, Muthing J (2019) PapG subtype-specific binding characteristics of Escherichia coli towards globo-series glycosphingolipids of human kidney and bladder uroepithelial cells. Glycobiology 29: 789-802

    Li YT, Goswami D, Follmer M, Artz A, Pacheco-Blanco M, Vestweber D (2019) Blood flow guides sequential support of neutrophil arrest and diapedesis by PILR-beta1 and PILR-alpha. Elife 8 pii: e47642

    Masthoff M, Buchholz R, Beuker A, Wachsmuth L, Kraupner A, Albers F, Freppon F, Helfen A, Gerwing M, Holtke C, Hansen U, Rehkamper J, Vielhaber T, Heindel W, Eisenblatter M, Karst U, Wildgruber M, Faber C (2019) Introducing Specificity to Iron Oxide Nanoparticle Imaging by Combining (57)Fe-Based MRI and Mass Spectrometry. Nano Lett 19: 7908-7917

    Matos ADR, Wunderlich K, Schloer S, Schughart K, Geffers R, Seders M, Witt M, Christersson A, Wiewrodt R, Wiebe K, Barth P, Hocke A, Hippenstiel S, Honzke K, Dittmer U, Sutter K, Rescher U, Rodionycheva S, Matera N, Ludwig S & Brunotte L (2019) Antiviral potential of human IFN-alpha subtypes against influenza A H3N2 infection in human lung explants reveals subtype-specific activities. Emerg Microbes Infect 8: 1763-1776

    Mewes M, Lenders M, Stappers F, Scharnetzki D, Nedele J, Fels J, Wedlich-Söldner R, Brand SM, Schmitz B, Brand E (2019) Soluble adenylyl cyclase (sAC) regulates calcium signaling in the vascular endothelium. FASEB J 33: 13762-13774

    Park H, Yamamoto H, Mohn L, Ambuhl L, Kanai K, Schmidt I, Kim KP, Fraccaroli A, Feil S, Junge HJ, Montanez E, Berger W, Adams RH (2019) Integrin-linked kinase controls retinal angiogenesis and is linked to Wnt signaling and exudative vitreoretinopathy. Nat Commun 10: 5243

    Petri J, Syed MH, Rey S, Klämbt C (2019) Non-Cell-Autonomous Function of the GPI-Anchored Protein Undicht during Septate Junction Assembly. Cell Rep 26: 1641-1653 e4

    Preugschas HF, Hrincius ER, Mewis C, Tran GVQ, Ludwig S, Ehrhardt C (2019) Late activation of the Raf/MEK/ERK pathway is required for translocation of the respiratory syncytial virus F protein to the plasma membrane and efficient viral replication. Cell Microbiol 21: e12955

    Rezaei M, Martins Cavaco AC, Seebach J, Niland S, Zimmermann J, Hanschmann EM, Hallmann R, Schillers H, Eble JA (2019) Signals of the Neuropilin-1-MET Axis and Cues of Mechanical Force Exertion Converge to Elicit Inflammatory Activation in Coherent Endothelial Cells. J Immunol 202: 1559-1572

    Sauerwald J, Backer W, Matzat T, Schnorrer F, Luschnig S (2019) Matrix metalloproteinase 1 modulates invasive behavior of tracheal branches during entry into Drosophila flight muscles. Elife 8 pii: e48857

    Schloer S, Goretzko J, Kuhnl A, Brunotte L, Ludwig S, Rescher U (2019) The clinically licensed antifungal drug itraconazole inhibits influenza virus in vitro and in vivo. Emerg Microbes Infect 8: 80-93

    Schloer S, Hubel N, Masemann D, Pajonczyk D, Brunotte L, Ehrhardt C, Brandenburg LO, Ludwig S, Gerke V, Rescher U (2019) The annexin A1/FPR2 signaling axis expands alveolar macrophages, limits viral replication, and attenuates pathogenesis in the murine influenza A virus infection model. FASEB J 33: 12188-12199

    Schreiber A, Liedmann S, Brunotte L, Anhlan D, Ehrhardt C, Ludwig S (2019) Type I interferon antagonistic properties of influenza B virus polymerase proteins. Cell Microbiol: e13143

    Tangherlini G, Kalinin DV, Schepmann D, Che T, Mykicki N, Stander S, Loser K, Wunsch B (2019) Development of Novel Quinoxaline-Based kappa-Opioid Receptor Agonists for the Treatment of Neuroinflammation. J Med Chem 62: 893-907

    Weishaupt C, Steinert M, Brunner G, Schulze HJ, Fuhlbrigge RC, Goerge T, Loser K (2019) Activation of human vascular endothelium in melanoma metastases induces ICAM-1 and E-selectin expression and results in increased infiltration with effector lymphocytes. Exp Dermatol 28: 1258-1269

    Willekens B, Presas-Rodríguez S, Mansilla MJ, Derdelinckx J, Lee WP, Nijs G, De Laere M, Wens I, Cras P, Parizel P, Van Hecke W, Ribbens A, Billiet T, Adams G, Couttenye MM, Navarro-Barriuso J, Teniente-Serra A, Quirant-Sánchez B, Lopez-Diaz de Cerio A, Inogés S, Prosper F, Kip A, Verheij H, Gross CC, Wiendl H, Van Ham MS, Ten Brinke A, Barriocanal AM, Massuet-Vilamajó A, Hens N, Berneman Z, Martínez-Cáceres E, Cools N, Ramo-Tello C & consortium R (2019) Tolerogenic dendritic cell-based treatment for multiple sclerosis (MS): a harmonised study protocol for two phase I clinical trials comparing intradermal and intranodal cell administration. BMJ Open 9: e030309

  • Publications 2018

    Babatz F, Naffin E, Klämbt C (2018) The Drosophila Blood-Brain Barrier Adapts to Cell Growth by Unfolding of Pre-existing Septate Junctions. Dev Cell 47: 697-710 e3

    Bauer R, Udonta F, Wroblewski M, Ben-Batalla I, Santos IM, Taverna F, Kuhlencord M, Gensch V, Pasler S, Vinckier S, Brandner JM, Pantel K, Bokemeyer C, Vogl T, Roth J, Carmeliet P, Loges S (2018) Blockade of Myeloid-Derived Suppressor Cell Expansion with All-Trans Retinoic Acid Increases the Efficacy of Antiangiogenic Therapy. Cancer Res 78: 3220-3232

    Baumann D, Salia H, Greune L, Norkowski S, Korner B, Uckeley ZM, Frankel G, Guenot M, Rüter C, Schmidt MA (2018) Multitalented EspB of enteropathogenic Escherichia coli (EPEC) enters cells autonomously and induces programmed cell death in human monocytic THP-1 cells. Int J Med Microbiol 308: 387-404

    Berger M, Berger P, Denamur E, Mellmann A, Dobrindt U (2018) Core elements of the vegetative replication control of the Inc1 plasmid pO104_90 of Escherichia coli O104:H4 also regulate its transfer frequency. Int J Med Microbiol 308: 962-968

    Bielaszewska M, Marejkova M, Bauwens A, Kunsmann-Prokscha L, Mellmann A, Karch H (2018) Enterohemorrhagic Escherichia coli O157 outer membrane vesicles induce interleukin 8 production in human intestinal epithelial cells by signaling via Toll-like receptors TLR4 and TLR5 and activation of the nuclear factor NF-kappaB. Int J Med Microbiol 308: 882-889

    Bommer A, Bohler O, Johannsen E, Dobrindt U, Kuczius T (2018) Effect of chlorine on cultivability of Shiga toxin producing Escherichia coli (STEC) and beta-lactamase genes carrying E. coli and Pseudomonas aeruginosa. Int J Med Microbiol 308: 1105-1112

    Bruchhagen C, Jarick M, Mewis C, Hertlein T, Niemann S, Ohlsen K, Peters G, Planz O, Ludwig S, Ehrhardt C (2018) Metabolic conversion of CI-1040 turns a cellular MEK-inhibitor into an antibacterial compound. Sci Rep 8: 9114

    de Winde CM, Matthews AL, van Deventer S, van der Schaaf A, Tomlinson ND, Jansen E, Eble JA, Nieswandt B, McGettrick HM, Figdor CG, Tomlinson MG, Acton SE, van Spriel AB (2018) C-type lectin-like receptor 2 (CLEC-2)-dependent dendritic cell migration is controlled by tetraspanin CD37. J Cell Sci 131

    Galstyan A, Dobrindt U (2018) Breaching the wall: morphological control of efficacy of phthalocyanine-based photoantimicrobials. J Mater Chem B 6: 4630-4637

    Galstyan A, Putze J, Dobrindt U (2018) Gaining Access to Bacteria through (Reversible) Control of Lipophilicity. Chemistry 24: 1178-1186

    Gran S, Honold L, Fehler O, Zenker S, Eligehausen S, Kuhlmann MT, Geven E, van den Bosch M, van Lent P, Spiekermann C, Hermann S, Vogl T, Schafers M, Roth J (2018) Imaging, myeloid precursor immortalization, and genome editing for defining mechanisms of leukocyte recruitment in vivo. Theranostics 8: 2407-2423

    Haarmann N, Berger M, Kouzel IU, Mellmann A, Berger P (2018) Comparative virulence characterization of the Shiga toxin phage-cured Escherichia coli O104:H4 and enteroaggregative Escherichia coli. Int J Med Microbiol 308: 912-920

    Hannocks MJ, Pizzo ME, Huppert J, Deshpande T, Abbott NJ, Thorne RG, Sorokin L (2018) Molecular characterization of perivascular drainage pathways in the murine brain. J Cereb Blood Flow Metab 38: 669-686

    Heitzig N, Kuhnl A, Grill D, Ludewig K, Schloer S, Galla HJ, Grewal T, Gerke V, Rescher U (2018) Cooperative binding promotes demand-driven recruitment of AnxA8 to cholesterol-containing membranes. Biochim Biophys Acta Mol Cell Biol Lipids 1863: 349-358

    Heming M, Gran S, Jauch SL, Fischer-Riepe L, Russo A, Klotz L, Hermann S, Schafers M, Roth J, Barczyk-Kahlert K (2018) Peroxisome Proliferator-Activated Receptor-gamma Modulates the Response of Macrophages to Lipopolysaccharide and Glucocorticoids. Front Immunol 9: 893

    Krischuns T, Gunl F, Henschel L, Binder M, Willemsen J, Schloer S, Rescher U, Gerlt V, Zimmer G, Nordhoff C, Ludwig S, Brunotte L (2018) Phosphorylation of TRIM28 Enhances the Expression of IFN-beta and Proinflammatory Cytokines During HPAIV Infection of Human Lung Epithelial Cells. Front Immunol 9: 2229

    Kühnl A, Musiol A, Heitzig N, Johnson DE, Ehrhardt C, Grewal T, Gerke V, Ludwig S, Rescher U (2018) Late Endosomal/Lysosomal Cholesterol Accumulation Is a Host Cell-Protective Mechanism Inhibiting Endosomal Escape of Influenza A Virus. mBio 9

    Lohmann L, Janoschka C, Schulte-Mecklenbeck A, Klinsing S, Kirstein L, Hanning U, Wirth T, Schneider-Hohendorf T, Schwab N, Gross CC, Eveslage M, Meuth SG, Wiendl H, Klotz L (2018) Immune Cell Profiling During Switching from Natalizumab to Fingolimod Reveals Differential Effects on Systemic Immune-Regulatory Networks and on Trafficking of Non-T Cell Populations into the Cerebrospinal Fluid-Results from the ToFingo Successor Study. Front Immunol 9: 1560

    Masemann D, Kother K, Kuhlencord M, Varga G, Roth J, Lichty BD, Rapp UR, Wixler V, Ludwig S (2018) Oncolytic influenza virus infection restores immunocompetence of lung tumor-associated alveolar macrophages. Oncoimmunology 7: e1423171

    Masemann D, Leite Dantas R, Sitnik S, Schied T, Nordhoff C, Ludwig S, Wixler V (2018) The Four-and-a-Half LIM Domain Protein 2 Supports Influenza A Virus-Induced Lung Inflammation by Restricting the Host Adaptive Immune Response. Am J Pathol 188: 1236-1245

    Masthoff M, Gran S, Zhang X, Wachsmuth L, Bietenbeck M, Helfen A, Heindel W, Sorokin L, Roth J, Eisenblatter M, Wildgruber M, Faber C (2018) Temporal window for detection of inflammatory disease using dynamic cell tracking with time-lapse MRI. Sci Rep 8: 9563

    Niemann S, Bertling A, Brodde MF, Fender AC, Van de Vyver H, Hussain M, Holzinger D, Reinhardt D, Peters G, Heilmann C, Loffler B, Kehrel BE (2018) Panton-Valentine Leukocidin associated with S. aureus osteomyelitis activates platelets via neutrophil secretion products. Sci Rep 8: 2185

    Niland S, Komljenovic D, Macas J, Bracht T, Bauerle T, Liebner S, Eble JA (2018) Rhodocetin-alphabeta selectively breaks the endothelial barrier of the tumor vasculature in HT1080 fibrosarcoma and A431 epidermoid carcinoma tumor models. Oncotarget 9: 22406-22422

    Norkowski S, Korner B, Greune L, Stolle AS, Lubos ML, Hardwidge PR, Schmidt MA, Rüter C (2018) Bacterial LPX motif-harboring virulence factors constitute a species-spanning family of cell-penetrating effectors. Cell Mol Life Sci 75: 2273-2289

    Phillips-Houlbracq M, Ricard JD, Foucrier A, Yoder-Himes D, Gaudry S, Bex J, Messika J, Margetis D, Chatel J, Dobrindt U, Denamur E, Roux D (2018) Pathophysiology of Escherichia coli pneumonia: Respective contribution of pathogenicity islands to virulence. Int J Med Microbiol 308: 290-296

    Prystopiuk V, Fels B, Simon CS, Liashkovich I, Pasrednik D, Kronlage C, Wedlich-Söldner R, Oberleithner H, Fels J (2018) A two-phase response of endothelial cells to hydrostatic pressure. J Cell Sci 131(12). pii: jcs206920.

    Schmidt T, Lorenz N, Raker VK, Schmidgen MI, Mahnke K, Enk A, Roth J, Steinbrink K (2018) Allergen-Specific Low Zone Tolerance Is Independent of MRP8/14-, TLR4-, TLR7-, and TLR9-Mediated Immune Processes. J Invest Dermatol 138: 452-455

    Schräder T, Dudek SE, Schreiber A, Ehrhardt C, Planz O, Ludwig S (2018) The clinically approved MEK inhibitor Trametinib efficiently blocks influenza A virus propagation and cytokine expression. Antiviral Res 157: 80-92

    Spiekermann C, Roth J, Vogl T, Stenner M, Rudack C (2018) Potential of the Novel PTA Score to Identify Patients with Peritonsillar Inflammation Profiting from Medical Treatment. Dis Markers 2018: 2040746

    Steil D, Pohlentz G, Legros N, Mormann M, Mellmann A, Karch H, Muthing J (2018) Combining Mass Spectrometry, Surface Acoustic Wave Interaction Analysis, and Cell Viability Assays for Characterization of Shiga Toxin Subtypes of Pathogenic Escherichia coli Bacteria. Anal Chem 90: 8989-8997

    Stork C, Kovacs B, Rozsai B, Putze J, Kiel M, Dorn A, Kovacs J, Melegh S, Leimbach A, Kovacs T, Schneider G, Kerenyi M, Emody L, Dobrindt U (2018a) Characterization of Asymptomatic Bacteriuria Escherichia coli Isolates in Search of Alternative Strains for Efficient Bacterial Interference against Uropathogens. Front Microbiol 9: 214

    Stork C, Kovacs B, Trost E, Kovacs T, Schneider G, Rozsai B, Kerenyi M, Emody L, Dobrindt U (2018b) Whole-Genome Draft Sequences of Nine Asymptomatic Escherichia coli Bacteriuria Isolates from Diabetic Patients. Genome Announc 6(2). pii: e01369-17.

    Susek, K. H., Korpos E, Huppert J, Wu C, Savelyeva I, Rosenbauer F, Müller-Tidow C, Koschmieder S , Sorokin L (2018) Bone marrow laminins influence hematopoietic stem and progenitor cell cycling and homing to the bone marrow. Matrix Biol, 67, 47-62.

    Ter Haar NM, Tak T, Mokry M, Scholman RC, Meerding JM, de Jager W, Verwoerd A, Foell D, Vogl T, Roth J, Leliefeld PHC, van Loosdregt J, Koenderman L, Vastert SJ, de Roock S (2018) Reversal of Sepsis-Like Features of Neutrophils by Interleukin-1 Blockade in Patients With Systemic-Onset Juvenile Idiopathic Arthritis. Arthritis Rheumatol 70: 943-956

    van Kruchten A, Wilden JJ, Niemann S, Peters G, Loffler B, Ludwig S, Ehrhardt C (2018) Staphylococcus aureus triggers a shift from influenza virus-induced apoptosis to necrotic cell death. FASEB J 32: 2779-2793

    Vogl T, Stratis A, Wixler V, Voller T, Thurainayagam S, Jorch SK, Zenker S, Dreiling A, Chakraborty D, Frohling M, Paruzel P, Wehmeyer C, Hermann S, Papantonopoulou O, Geyer C, Loser K, Schafers M, Ludwig S, Stoll M, Leanderson T, Schultze JL, König S, Pap T,RothJ(2018) Autoinhibitory regulation of S100A8/S100A9 alarmin activity locally restricts sterile inflammation. J Clin Invest 128: 1852-1866

    Volkenhoff A, Hirrlinger J, Kappel JM, Klämbt C, Schirmeier S (2018) Live imaging using a FRET glucose sensor reveals glucose delivery to all cell types in the Drosophila brain. J Insect Physiol 106: 55-64

    Völler T, Faust A, Roth J, Schafers M, Vogl T, Hermann S (2018) A Non-Peptidic S100A9 Specific Ligand for Optical Imaging of Phagocyte Activity In Vivo. Mol Imaging Biol 20: 407-416

  • Publications 2017

    Albrecht S, Fleck AK, Kirchberg I, Hucke S, Liebmann M, Klotz L, Kuhlmann T (2017) Activation of FXR pathway does not alter glial cell function. J Neuroinflammation 14: 66

    Bauwens A, Kunsmann L, Karch H, Mellmann A, Bielaszewska M (2017a) Antibiotic-Mediated Modulations of Outer Membrane Vesicles in Enterohemorrhagic Escherichia coli O104:H4 and O157:H7. Antimicrob Agents Chemother 61

    Bauwens A, Kunsmann L, Marejkova M, Zhang W, Karch H, Bielaszewska M, Mellmann A (2017b) Intrahost milieu modulates production of outer membrane vesicles, vesicle-associated Shiga toxin 2a and cytotoxicity in Escherichia coli O157:H7 and O104:H4. Environ Microbiol Rep 9: 626-634

    Bielaszewska M, Ruter C, Bauwens A, Greune L, Jarosch KA, Steil D, Zhang W, He X, Lloubes R, Fruth A, Kim KS, Schmidt MA, Dobrindt U, Mellmann A, Karch H (2017) Host cell interactions of outer membrane vesicle-associated virulence factors of enterohemorrhagic Escherichia coli O157: Intracellular delivery, trafficking and mechanisms of cell injury. PLoS Pathog 13: e1006159

    Boras M, Volmering S, Bokemeyer A, Rossaint J, Block H, Bardel B, Van Marck V, Heitplatz B, Kliche S, Reinhold A, Lowell C, Zarbock A (2017) Skap2 is required for beta2 integrin-mediated neutrophil recruitment and functions. J Exp Med 214: 851-874

    Boye TL, Maeda K, Pezeshkian W, Sonder SL, Haeger SC, Gerke V, Simonsen AC, Nylandsted J (2017) Annexin A4 and A6 induce membrane curvature and constriction during cell membrane repair. Nat Commun 8: 1623

    Chakraborty D, Zenker S, Rossaint J, Holscher A, Pohlen M, Zarbock A, Roth J, Vogl T (2017) Alarmin S100A8 Activates Alveolar Epithelial Cells in the Context of Acute Lung Injury in a TLR4-Dependent Manner. Front Immunol 8: 1493

    Di Russo, J., Hannocks MJ, Luik AL, Song J, Zhang X, Yousif L, Aspite G, Hallmann R & Sorokin L (2017a) Vascular laminins in physiology and pathology. Matrix Biol, 57-58, 140-148

    Di Russo J, Luik AL, Yousif L, Budny S, Oberleithner H, Hofschröer V, Klingauf J, van Bavel E, Bakker EN, Hellstrand P, Bhattachariya A, Albinsson S, Pincet F, Hallmann R, Sorokin LM (2017) Endothelial basement membrane laminin 511 is essential for shear stress response. EMBO J 36: 183-201

    Eble JA, McDougall M, Orriss GL, Niland S, Johanningmeier B, Pohlentz G, Meier M, Karrasch S, Estevao-Costa MI, Martins Lima A, Stetefeld J (2017) Dramatic and concerted conformational changes enable rhodocetin to block alpha2beta1 integrin selectively. PLoS Biol 15: e2001492

    Eilken HM, Diéguez-Hurtado R, Schmidt I, Nakayama M, Jeong HW, Arf H, Adams S, Ferrara N, Adams RH (2017) Pericytes regulate VEGF-induced endothelial sprouting through VEGFR1. Nat Commun 8: 1574

    Eisenblaetter M, Flores-Borja F, Lee JJ, Wefers C, Smith H, Hueting R, Cooper MS, Blower PJ, Patel D, Rodriguez-Justo M, Milewicz H, Vogl T, Roth J, Tutt A, Schaeffter T, Ng T (2017) Visualization of Tumor-Immune Interaction - Target-Specific Imaging of S100A8/A9 Reveals Pre-Metastatic Niche Establishment. Theranostics 7: 2392-2401

    Galstyan A, Schiller R, Dobrindt U (2017) Boronic Acid Functionalized Photosensitizers: A Strategy To Target the Surface of Bacteria and Implement Active Agents in Polymer Coatings. Angew Chem Int Ed Engl 56: 10362-10366

    Goswami D, Marz S, Li YT, Artz A, Schafer K, Seelige R, Pacheco-Blanco M, Jing D, Bixel MG, Araki M, Araki K, Yamamura KI, Vestweber D (2017) Endothelial CD99 supports arrest of mouse neutrophils in venules and binds to neutrophil PILRs. Blood 129: 1811-1822

    Granado D, Muller D, Krausel V, Kruzel-Davila E, Schuberth C, Eschborn M, Wedlich-Söldner R, Skorecki K, Pavenstädt H, Michgehl U, Weide T (2017) Intracellular APOL1 Risk Variants Cause Cytotoxicity Accompanied by Energy Depletion. J Am Soc Nephrol 28: 3227-3238

    Gross CC, Schulte-Mecklenbeck A, Hanning U, Posevitz-Fejfar A, Korsukewitz C, Schwab N, Meuth SG, Wiendl H, Klotz L (2017) Distinct pattern of lesion distribution in multiple sclerosis is associated with different circulating T-helper and helper-like innate lymphoid cell subsets. Mult Scler 23: 1025-1030

    Haasbach E, Muller C, Ehrhardt C, Schreiber A, Pleschka S, Ludwig S, Planz O (2017) The MEK-inhibitor CI-1040 displays a broad anti-influenza virus activity in vitro and provides a prolonged treatment window compared to standard of care in vivo. Antiviral Res 142: 178-184

    Heinemann AS, Pirr S, Fehlhaber B, Mellinger L, Burgmann J, Busse M, Ginzel M, Friesenhagen J, von Kockritz-Blickwede M, Ulas T, von Kaisenberg CS, Roth J, Vogl T, Viemann D (2017) In neonates S100A8/S100A9 alarmins prevent the expansion of a specific inflammatory monocyte population promoting septic shock. FASEB J 31: 1153-1164

    Heitmueller M, Billion A, Dobrindt U, Vilcinskas A, Mukherjee K (2017) Epigenetic Mechanisms Regulate Innate Immunity against Uropathogenic and Commensal-Like Escherichia coli in the Surrogate Insect Model Galleria mellonella. Infect Immun 85

    Heitzig N, Brinkmann BF, Koerdt SN, Rosso G, Shahin V, Rescher U (2017) Annexin A8 promotes VEGF-A driven endothelial cell sprouting. Cell Adh Migr 11: 275-287

    Holzberg M, Boergeling Y, Schrader T, Ludwig S, Ehrhardt C (2017) Vemurafenib Limits Influenza A Virus Propagation by Targeting Multiple Signaling Pathways. Front Microbiol 8: 2426

    Jakobs, P, Schulz P, Schurmann S, Niland S, Exner S, Rebollido-Rios R, Manikowski D, Hoffmann D, Seidler DG & Grobe K (2017) Ca(2+) coordination controls sonic hedgehog structure and its Scube2-regulated release. J Cell Sci, 130, 3261-3271

    Klemm C, Bruchhagen C, van Kruchten A, Niemann S, Loffler B, Peters G, Ludwig S, Ehrhardt C (2017) Mitogen-activated protein kinases (MAPKs) regulate IL-6 over-production during concomitant influenza virus and Staphylococcus aureus infection. Sci Rep 7: 42473

    Koerdt SN, Gerke V (2017) Annexin A2 is involved in Ca(2+)-dependent plasma membrane repair in primary human endothelial cells. Biochim Biophys Acta Mol Cell Res 1864: 1046-1053

    Lebughe M, Phaku P, Niemann S, Mumba D, Peters G, Muyembe-Tamfum JJ, Mellmann A, Strauss L, Schaumburg F (2017) The Impact of the Staphylococcus aureus Virulome on Infection in a Developing Country: A Cohort Study. Front Microbiol 8: 1662

    Leite Dantas R, Brachvogel B, Schied T, Bergmeier V, Skryabin B, Vogl T, Ludwig S, Wixler V (2017) The LIM-Only Protein Four and a Half LIM Domain Protein 2 Attenuates Development of Psoriatic Arthritis by Blocking Adam17-Mediated Tumor Necrosis Factor Release. Am J Pathol 187: 2388-2398

    Lueck K, Carr AF, Stampoulis D, Gerke V, Rescher U, Greenwood J, Moss SE (2017) Regulation of retinal pigment epithelial cell phenotype by Annexin A8. Sci Rep 7: 4638

    Misra T, Baccino Calace M, Meyenhofer T, Rodriguez-Crespo D, Akarsu H, Armenta-Calderón R, Gorr TA, Frei C, Cantera R, Egger B, Luschnig, S (2017) A genetically encoded biosensor for visualizing hypoxia responses in vivo. Biology Open 6(2): 296-304

    Mykicki N, Klenner L, Baumann C, Auriemma M, Sternemann C, Soeberdt M, Elliott GR, Abels C, Luger TA, Loser K (2017) The tripeptide KdPT ameliorates ongoing psoriasis-like skin inflammation in murine and human skin. Exp Dermatol 26: 328-334

    Nacken W, Wixler V, Ehrhardt C, Ludwig S (2017) Influenza A virus NS1 protein-induced JNK activation and apoptosis are not functionally linked. Cell Microbiol 19

    Pirr S, Richter M, Fehlhaber B, Pagel J, Hartel C, Roth J, Vogl T, Viemann D (2017) High Amounts of S100-Alarmins Confer Antimicrobial Activity on Human Breast Milk Targeting Pathogens Relevant in Neonatal Sepsis. Front Immunol 8: 1822

    Risse B, Otto N, Berh D, Xiaoyi J, Kiel M, Klämbt C (2017) FIM2c: Multicolor, Multipurpose Imaging System to Manipulate and Analyze Animal Behavior. IEEE Trans Biomed Eng 64: 610-620

    Song J, Zhang X, Buscher K, Wang Y, Wang H, Di Russo J, Li L, Lutke-Enking S, Zarbock A, Stadtmann A, Striewski P, Wirth B, Kuzmanov I, Wiendl H, Schulte D, Vestweber D, Sorokin L (2017) Endothelial Basement Membrane Laminin 511 Contributes to Endothelial Junctional Tightness and Thereby Inhibits Leukocyte Transmigration. Cell Rep 18: 1256-1269

    Spiekermann C, Russo A, Stenner M, Rudack C, Roth J, Vogl T (2017) Increased Levels of S100A8/A9 in Patients with Peritonsillar Abscess: A New Promising Diagnostic Marker to Differentiate between Peritonsillar Abscess and Peritonsillitis. Dis Markers 2017: 9126560

    Stolle AS, Norkowski S, Korner B, Schmitz J, Luken L, Frankenberg M, Rüter C, Schmidt MA (2017) T3SS-Independent Uptake of the Short-Trip Toxin-Related Recombinant NleC Effector of Enteropathogenic Escherichia coli Leads to NF-kappaB p65 Cleavage. Front Cell Infect Microbiol 7: 119

    Tholking G, Schuette-Nuetgen K, Vogl T, Dobrindt U, Kahl BC, Brand M, Pavenstädt H, Suwelack B, Koch R, Reuter S (2017) Male kidney allograft recipients at risk for urinary tract infection? PLoS One 12: e0188262

    Ulas T, Pirr S, Fehlhaber B, Bickes MS, Loof TG, Vogl T, Mellinger L, Heinemann AS, Burgmann J, Schoning J, Schreek S, Pfeifer S, Reuner F, Vollger L, Stanulla M, von Kockritz-Blickwede M, Glander S, Barczyk-Kahlert K, von Kaisenberg CS, Friesenhagen J,Fischer-Riepe L, Zenker S, Schultze JL, Roth J & Vieman D (2017) S100-alarmin-induced innate immune programming protects newborn infants from sepsis. Nat Immunol 18: 622-632

    Wiegand S, Zakrzewski SS, Eichner M, Schulz E, Günzel D, Pieper R, Rosenthal R, Barmeyer C, Bleich A, Dobrindt U, Schulzke JD, Bücker R (2017) Zinc treatment is efficient against Escherichia coli α-haemolysin-induced intestinal leakage in mice. Sci Rep 7: 45649

  • Publications 2016

    Ambite I, Lutay N, Stork C, Dobrindt U, Wullt B, Svanborg C (2016) Bacterial Suppression of RNA Polymerase II-Dependent Host Gene Expression. Pathogens 5(3). pii: E49.

    Artz A, Butz S, Vestweber D (2016) GDF-15 inhibits integrin activation and mouse neutrophil recruitment through the ALK-5/TGF-betaRII heterodimer. Blood 128: 529-541

    Berger P, Knodler M, Forstner KU, Berger M, Bertling C, Sharma CM, Vogel J, Karch H, Dobrindt U, Mellmann A (2016) The primary transcriptome of the Escherichia coli O104:H4 pAA plasmid and novel insights into its virulence gene expression and regulation. Sci Rep 6: 35307

    Block H, Stadtmann A, Riad D, Rossaint J, Sohlbach C, Germena G, Wu D, Simon SI, Ley K, Zarbock A (2016) Gnb isoforms control a signaling pathway comprising Rac1, Plcbeta2, and Plcbeta3 leading to LFA-1 activation and neutrophil arrest in vivo. Blood 127: 314-24

    Buscher K, Wang H, Zhang X, Striewski P, Wirth B, Saggu G, Lütke-Enking S, Mayadas TN, Ley K, Sorokin L, Song J (2016) Protection from septic peritonitis by rapid neutrophil recruitment through omental high endothelial venules. Nat Commun 7: 10828

    Dudek SE, Nitzsche K, Ludwig S, Ehrhardt C (2016) Influenza A viruses suppress cyclooxygenase-2 expression by affecting its mRNA stability. Sci Rep 6: 27275

    Ghatak S, Niland S, Schulz JN, Wang F, Eble JA, Leitges M, Mauch C, Krieg T, Zigrino P, Eckes B (2016) Role of Integrins alpha1beta1 and alpha2beta1 in Wound and Tumor Angiogenesis in Mice. Am J Pathol 186: 3011-3027

    Hessner F, Dlugos CP, Chehab T, Schaefer C, Homey B, Gerke V, Weide T, Pavenstädt H, Rescher U (2016) CC chemokine receptor 10 cell surface presentation in melanocytes is regulated by the novel interaction partner S100A10. Sci Rep 6: 22649

    Kathum OA, Schräder T, Anhlan D, Nordhoff C, Liedmann S, Pande A, Mellmann A, Ehrhardt C, Wixler V, Ludwig S (2016) Phosphorylation of influenza A virus NS1 protein at threonine 49 suppresses its interferon antagonistic activity. Cell Microbiol 18: 784-91

    Klasen T, Faber C (2016) Assessment of the myelin water fraction in rodent spinal cord using T2-prepared ultrashort echo time MRI. MAGMA 29: 875-884

    Klotz L, Kuzmanov I, Hucke S, Gross CC, Posevitz V, Dreykluft A, Schulte-Mecklenbeck A, Janoschka C, Lindner M, Herold M, Schwab N, Ludwig-Portugall I, Kurts C, Meuth SG, Kuhlmann T, Wiendl H (2016) B7-H1 shapes T-cell-mediated brain endothelial cell dysfunction and regional encephalitogenicity in spontaneous CNS autoimmunity. Proc Natl Acad Sci U S A 113: E6182-E6191

    Kuehnl A, Musiol A, Raabe CA, Rescher U (2016) Emerging functions as host cell factors - an encyclopedia of annexin-pathogen interactions. Biol Chem 397: 949-59

    Kuzmanov I, Herrmann AM, Galla HJ, Meuth SG, Wiendl H, Klotz L (2016) An In Vitro Model of the Blood-brain Barrier Using Impedance Spectroscopy: A Focus on T Cell-endothelial Cell Interaction. J Vis Exp 8(118)

    Leite Dantas R, Masemann D, Schied T, Bergmeier V, Vogl T, Loser K, Brachvogel B, Varga G, Ludwig S, Wixler V (2016) Macrophage-mediated psoriasis can be suppressed by regulatory T lymphocytes. J Pathol 240: 366-377

    Muenzner P, Kengmo Tchoupa A, Klauser B, Brunner T, Putze J, Dobrindt U, Hauck CR (2016) Uropathogenic E. coli Exploit CEA to Promote Colonization of the Urogenital Tract Mucosa. PLoS Pathog 12: e1005608

    Mykicki N, Herrmann AM, Schwab N, Deenen R, Sparwasser T, Limmer A, Wachsmuth L, Klotz L, Kohrer K, Faber C, Wiendl H, Luger TA, Meuth SG, Loser K (2016) Melanocortin-1 receptor activation is neuroprotective in mouse models of neuroinflammatory disease. Sci Transl Med 8: 362ra146

    O'Halloran PJ, Viel T, Murray DW, Wachsmuth L, Schwegmann K, Wagner S, Kopka K, Jarzabek MA, Dicker P, Hermann S, Faber C, Klasen T, Schafers M, O'Brien D, Prehn JH, Jacobs AH, Byrne AT (2016) Mechanistic interrogation of combination bevacizumab/dual PI3K/mTOR inhibitor response in glioblastoma implementing novel MR and PET imaging biomarkers. Eur J Nucl Med Mol Imaging 43: 1673-83

    Otto N, Risse B, Berh D, Bittern J, Jiang X, Klämbt C (2016) Interactions among Drosophila larvae before and during collision. Sci Rep 6: 31564

    Pelillo C, Mollica H, Eble JA, Grosche J, Herzog L, Codan B, Sava G, Bergamo A (2016) Inhibition of adhesion, migration and of alpha5beta1 integrin in the HCT-116 colorectal cancer cells treated with the ruthenium drug NAMI-A. J Inorg Biochem 160: 225-35

    Rossaint J, Oehmichen J, Van Aken H, Reuter S, Pavenstädt HJ, Meersch M, Unruh M, Zarbock A (2016) FGF23 signaling impairs neutrophil recruitment and host defense during CKD. J Clin Invest 126: 962-74

    Sanchez EF, Richardson M, Gremski LH, Veiga SS, Yarleque A, Niland S, Lima AM, Estevao-Costa MI, Eble JA (2016a) A novel fibrinolytic metalloproteinase, barnettlysin-I from Bothrops barnetti (Barnett s pitviper) snake venom with anti-platelet properties. Biochim Biophys Acta 1860: 542-56

    Sanchez EF, Richardson M, Gremski LH, Veiga SS, Yarleque A, Niland S, Lima AM, Estevao-Costa MI, Eble JA (2016b) Data for a direct fibrinolytic metalloproteinase, barnettlysin-I from Bothrops barnetti (barnett(,)s pitviper) snake venom with anti-thrombotic effect. Data Brief 7: 1609-13

    Strobel M, Pfortner H, Tuchscherr L, Volker U, Schmidt F, Kramko N, Schnittler HJ, Fraunholz MJ, Loffler B, Peters G, Niemann S (2016) Post-invasion events after infection with Staphylococcus aureus are strongly dependent on both the host cell type and the infecting S. aureus strain. Clin Microbiol Infect 22: 799-809

    Van Crombruggen K, Vogl T, Perez-Novo C, Holtappels G, Bachert C (2016) Differential release and deposition of S100A8/A9 proteins in inflamed upper airway tissue. Eur Respir J 47: 264-74

    Volmering S, Block H, Boras M, Lowell CA, Zarbock A (2016) The Neutrophil Btk Signalosome Regulates Integrin Activation during Sterile Inflammation. Immunity 44: 73-87

    Wales P, Schuberth CE, Aufschnaiter R, Fels J, Garcia-Aguilar I, Janning A, Dlugos CP, Schafer-Herte M, Klingner C, Walte M, Kuhlmann J, Menis E, Hockaday Kang L, Maier KC, Hou W, Russo A, Higgs HN, Pavenstädt H, Vogl T, Roth J, Wedlich-Söldner R (2016) Calcium-mediated actin reset (CaAR) mediates acute cell adaptations. Elife 5 pii: e19850.

    Wegner J, Loser K, Apsite G, Nischt R, Eckes B, Krieg T, Werner S, Sorokin L (2016) Laminin alpha5 in the keratinocyte basement membrane is required for epidermal-dermal intercommunication. Matrix Biol 56: 24-41

  • Publications 2015

    • Baldo C, Lopes DS, Faquim-Mauro EL, Jacysyn JF, Niland S, Eble JA, Clissa PB, Moura-da-Silva AM (2015) Jararhagin disruption of endothelial cell anchorage is enhanced in collagen enriched matrices. Toxicon 108:240-248.
    • Becker A, Große Hokamp N, Zenker S, Flores-Borja F, Barzcyk K, Varga G, Roth J, Geyer C, Heindel W, Bremer C, Vogl T*, Eisenblaetter M* (2015) In vivo visualisation of the alarmin S100A9 in tumor lesions allows for estimation of the individual malignant potential by evaluation of tumor host-cell interaction. J. Nuc. Med. 56:450-456. *Shared first or senior authorship
    • Block H, Stadtmann A, Riad D, Rossaint J, Sohlbach C, Germena G, Wu D, Simon SI, Ley K, Zarbock A. (2015) Gnb isoforms orchestrate a signaling pathway comprising Rac1 and Plcβ2/3 leading to LFA-1 activation and neutrophil arrest in vivo. Blood 2015 Oct 14. pii: blood-2015-06-651034
    • Börgeling Y, Rozhdestvensky TS, Schmolke M, Resa-Infante P, Robeck T, Randau G, Wolff T, Gabriel G, Brosius J, Ludwig S (2015) Evidence for a novel mechanism of influenza virus-induced type I interferon expression by a defective RNA-encoded protein. PLoS Pathog 11: e1004924.
    • Dankbar B, Fennen M, Brunert D, Hayer S, Frank S, Wehmeyer C, Beckmann D, Paruzel P, Bertrand J, Redlich K, Koers-Wunrau C, Stratis A, Korb-Pap A, Pap T (2015) Myostatin is a direct regulator of osteoclast differentiation and its inhibition reduces inflammatory joint destruction in mice. Nat Med. 21(9):1085-90.
    • Drechsler M, de Jong R, Rossaint J, Viola JR, Leoni G, Wang JM, Grommes J, Hinkel R, Kupatt C, Weber C, Döring Y, Zarbock A, Soehnlein O. (2015) Annexin A1 counteracts chemokine-induced arterial myeloid cell recruitment. Circ Res. 2015 Feb 27;116(5):827-35. AZ und OS contributed equally and share senior-authorship
    • Fassl SK, Austermann J, Papantonopoulou O, Riemenschneider M, Xue J, Bertheloot D, Freise N, Spiekermann C, Witten A, Viemann D, Kirschnek S, Stoll M, Latz E, Schultze JL, Roth J, Vogl T (2015) Transcriptome assessment reveals a dominant role for TLR4 in the activation of human phagocytes by the alarmin MRP8. J Immunol 194: 575-583.
    • Frye M, Dierkes M, Küppers V, Vockel M, Tomm J, Zeuschner D, Roissant J, Zarbock A, Koh GY, Peters K, Nottebaum AF, Vestweber D (2015) Interfering with VE-PTP stabilizes endothelial junctions in vivo via Tie-2 in the absence of VE-cadherin. J Exp Med 212: 2267-2287.
    • Germena G, Volmering S, Sohlbach C, Zarbock A. Mutation in the CD45 inhibitory wedge modulates integrin activation and leukocyte recruitment during inflammation. J Immunol 94:728.
    • Hallmann R, Zhang X, Di Russo J, Li L, Song J, Hannocks M-J, Sorokin L (2015) The regulation of immune cell trafficking by the extracellular matrix. Curr Opin Cell Biol 36: 54-61.
    • Herold M, Posevitz V, Chudyka D, Hucke S, Groß C, Kurth F, Leder C, Loser K, Kurts C, Knolle P, Klotz L, Wiendl H (2015) Selectively Controls TH17 Differentiation and Central Nervous System Autoimmunity via a Novel Non-PD-1-Mediated Pathway. J Immunol. 195(8):3584-95.
    • Hillgruber C, Pöppelmann B, Weishaupt C, Steingräber AK, Wessel F, Berdel WE, Gessner JE, Ho-Tin-Noé B, Vestweber D*, Goerge T*(2015) Blocking neutrophil diapedesis prevents hemorrhage during thrombocytopenia. J Exp Med 212: 1255-1266. (*equal contribution)
    • Holzinger D, Fassl SK, de Jager W, Lohse P, Rohrig UF, Gattorno M, Omenetti A, Chiesa S, Schena F, Austermann J, Vogl T, Kuhns DB, Holland SM, Rodriguez-Gallego C, Lopez-Almaraz R, Arostegui JI, Colino E, Roldan R, Fessatou S, Isidor B, Poignant S, Ito K, Epple HJ, Bernstein JA, Jeng M, Frankovich J, Lionetti G, Church JA, Ong PY, LaPlant M, Abinun M, Skinner R, Bigley V, Sachs UJ, Hinze C, Hoppenreijs E, Ehrchen J, Foell D, Chae JJ, Ombrello A, Aksentijevich I, Sunderkoetter C, Roth J (2015) Single amino acid charge switch defines clinically distinct proline-serine-threonine phosphatase-interacting protein 1 (PSTPIP1)-associated inflammatory diseases. J Allergy Clin Immunol 136: 1337-1345.
    • Höfling S, Grabowski B, Norkowski S, Schmidt MA, Rüter C. (2015) Current activities of the Yersinia effector protein YopM. Int J Med Microbiol., Apr 1., pii: S1438-4221(15)00028-4. doi: 10.1016/j.ijmm.2015.03.009.
    • Klenner L, Hafezi W, Clausen BE, Lorentzen EU, Luger TA, Beissert S, Kühn JE, Loser K (2015) Cutaneous RANK-RANKL signaling upregulates CD8-mediated antiviral immunity during Herpes simplex virus infection by preventing virus-induced Langerhans Cell apoptosis. J Invest Dermatol 135: 2676-2687.
    • Kunsmann L, Rüter C, Bauwens A, Greune L, Glüder M, Kemper B, Fruth A, Wai SN, He X, Lloubes R, Schmidt MA, Dobrindt U, Mellmann A, Karch H, Bielaszewska M (2015) Virulence from vesicles: Novel mechanisms of host cell injury by Escherichia coli O104:H4 outbreak strain. Sci Rep 5: 13252.
    • Liu Z, Xu Y, Zhang X, Song J, Sorokin L, Bähler M (2015) The motorized RhoGAP myosin IXb (Myo9b) in leukocytes regulates experimental autoimmune encephalomyelitis induction and recovery. J Neuroimmunol 282: 25-32.
    • Matzat T, Sieglitz F, Kottmeier R, Babatz F, Engelen D, Klämbt C (2015) Axonal wrapping in the Drosophila PNS is controlled by glia-derived neuregulin homolog Vein. Development 142: 1336-1345.
    • Momic T, Katzhendler J, Shai E, Noy E, Senderowitz H, Eble JA, Marcinkiewicz C, Varon D, Lazarovici P (2015) Vipegitide: A folded peptidomimetic partial antagonist of α2β1 integrin with antiplatelet aggregation activity. Drug Des Devel Ther 9: 291-304.
    • Pruenster M, Kurz ARM, Chung KJ, Cao-Ehlker X, Bieber S, Nussbaum CF, Bierschenk S, Eggersmann TK, Rohwedder I, Heinig K, Immler R, Moser M, Koedel U, Gran S, McEver RP, Vestweber D, Verschoor A, Leandersson T, Chavakis T, Roth J, Vogl T,* Sperandio M* (2015) Extracellular MRP8/14 is a regulator of β2 integrin-dependent neutrophil slow rolling and adhesion. Nat Commun. 6:6915.
    • Silva IT, Carvalho A, Lang KL, Dudek SE, Masemann D, Durán FJ, Duran FJ, Caro MSB, Rapp UR, Wixler V, Schenkel EP, Simões CMO, Ludwig S (2015) In vitro and in vivo antitumor activity of a novel semisynthetic derivative of cucurbitacin B. PLoS ONE 10(2): e0117794. (doi:10.1371/journal.pone.0117794) 
    • Stadtmann A, Block H, Volmering S, Abram C, Sohlbach C, Boras M, Lowell CA, Zarbock A. (2015) Cross-Talk between Shp1 and PIPKIγ Controls Leukocyte Recruitment. J Immunol. 2015 Aug 1;195(3):1152-61.
    • Song J, Wu C, Agrawal S, Korpos E, Wang Y, Faber C, Schäfers M, Körner H, Opdenakker G, Hallmann R, Sorokin L (2015) Focal MMP-2 and MMP-9 activity at the blood-brain barrier (BBB) promotes chemokine-induced leukocyte migration. Cell Reports 10 (7): 1040-1054. [doi: 10.1016/j.celrep.2015.01.037] Epub 2015 Feb 19.
    • Van Crombruggen K, Vogl T, Pérez-Novo C, Holtappels G, Bachert C (2016) Differential release and deposition of S100A8/A9 proteins in inflamed upper airway tissue. Eur Respir 47(1):264-274.
    • Volmering S, Block H, Boras M, Lowell C, Zarbock A, The neutrophil Btk signalosome regulates multiple Mac-1 integrin activation events involved in neutrophil recruitment and functions during sterile inflammation. Immunity. Accepted for publication 2015.
    • Volkenhoff A, Weiler A, Letzel M, Stehling M, Klämbt C, Schirmeier S (2015) Glial glycolysis is essential for neuronal survival in Drosophila. Cell Metab 22: 437-447.
    • Wache C, Klein M, Ostergaard C, Angele B, Häcker H, Pfister HW, Pruenster M, Sperandio M, Leanderson T,Roth J, Vogl T, Koedel U (2015) Myeloid-related protein 14 promote inflammation and injury in meningitis. J Infect Dis (in press).  (pii: jiv028. Epub ahead of print)
    • Warnking K, Klemm C, Löffler B, Niemann S, van Krüchten A, Peters G, Ludwig S, Ehrhardt C (2015) Super-infection with Staphylococcus aureus inhibits influenza virus-induced type I IFN signaling through impaired STAT1-STAT2 dimerization. Cell Microbiol 17 (3): 303-317.
    • Wehmeyer C, Frank S, Beckmann D, Böttcher M, Cromme C, König U, Fennen M, Held A, Paruzel P, Hartmann C, Stratis A, Korb-Pap A, Kamradt T, Kramer I, van den Berg W, Kneissel M, Pap T, Dankbar B (2016) Sclerostin inhibition promotes inflammatory joint destruction through enhanced activation of TNFR-mediated 151lanning151g. Sci Transl Med 8(330):330ra35.
  • Publications 2014

    • Austermann J, Friesenhagen J, Fassl SK, Ortkras T, Burgmann J, Barczyk-Kahlert K, Faist E, Zedler S, Pirr S, Rohde C, Müller-Tidow C, von Köckritz-Blickwede M, von Kaisenberg CS, Flohé SB, Ulas T, Schultze JL, Roth J, Vogl T, Viemann D (2014) Alarmins MRP8 and MRP14 Induce Stress Tolerance in Phagocytes under Sterile Inflammatory Conditions.Cell Rep 9(6): 2112-2123.
    • Bäumer N, Krause A, Köhler G, Lettermann S, Evers G, Hascher A, Bäumer S, Berdel WE, Müller-Tidow C, Tickenbrock L (2014) Proteinase-Activated Receptor 1 (PAR1) regulates leukemic stem cell functions. PLoS One 9 (4): e94993.
    • Bielaszewska M, Schiller R, Lammer L, Bauwens A, Fruth A, Middendorf B, Schmidt MA, Tarr PI, Dobrindt U, Karch H, Mellmann A (2014) Heteropathogenic virulence and phylogeny reveal phased pathogenic metamorphosis in Escherichia coli O2:H6. EMBO Mol Med 6: 347-357.
    • Bittner S, Ruck T, Göbel K, Henschel C, Afzali AM, Göb E, Müntefering T, Kleinschnitz C, Wiendl H, Meuth SG (2014) Effects of Glatiramer Acetate in a Spontaneous Model of Autoimmune Neuroinflammation. Am J Pathol 184(7): 2056-2065.
    • Bolas G, de Rezende FF, Lorente C, Sanz L, Eble JA, Calvete JJ (2014) Inhibitory effects of recombinant RTS-jerdostatin on integrin α1β1 function during adhesion, migration and proliferation of rat aortic smooth muscle cells and angiogenesis. Toxicon 79: 45-54.
    • Börgeling Y, Schmolke M, Viemann D, Nordhoff C, Roth J, Ludwig S (2014) Inhibition of p38 mitogen-activated protein kinase impairs influenza virus-induced primary and secondary host gene responses and protects mice from lethal H5N1 infection. J Biol Chem 289(1): 13-27.
    • Breuer J*, Schwab N*, Schneider-Hohendorf T, Marziniak M, Mohan H, Bhatia U, Gross CC,Clausen BE, Weishaupt C, Luger TA, Meuth SG, Loser K*, Wiendl H* (2014) Ultraviolet B light attenuates the systemic immune response in central nervous system autoimmunity. Ann Neurol 75: 739-758. *equal contribution.
    • Dierkes R, Warnking K, Liedmann S, Seyer R, Ludwig S, Ehrhardt C (2014) The Rac1 inhibitor NSC23766 exerts anti-influenza virus properties by affecting the viral polymerase complex activity. PloS one 9: e88520.
    • Herter JM, Rossaint J, Spieker T, Zarbock A (2014) Adhesion molecules involved in neutrophil recruitment during sepsis-induced acute kidney injury. J Innate Immun 6(5): 597-606.
    • Hoerr V, Faber C (2014) Magnetic resonance imaging characterization of microbial infections. J Pharm Biomed Anal 93: 136-146.
    • Holzinger D, Nippe N, Vogl T, Marketon K, Mysore V, Weinhage T, Dalbeth N, Pool B, Merriman T, Baeten D, Ives A, Busso N, Foell D, Bas S, Gabay C, Roth J (2014) Myeloid-related proteins 8 and 14 contribute to monosodium urate monohydrate crystal-induced inflammation in gout. Arthritis Rheumatol 66: 1327-1339.
    • Köther K, Nordhoff C, Masemann D, Varga G, Bream JH, Gaestel M, Wixler V, Ludwig S (2014) MAPKAP kinase 3 suppresses Ifng gene expression and attenuates NK cell cytotoxicity and Th1 CD4 T-cell development upon influenza A virus infection. FASEB J 28: 4235-4246.
    • Köves B, Salvador E, Grönberg-Hernandez J, Zdziarski J, Wullt B, Svanborg C, Dobrindt U (2014) Rare emergence of symptoms during long-term asymptomatic E. coli 83972 carriage, without altered virulence factor repertoire. J Urol 191: 519-528. doi:10.1016/j.juro.2013.07.060.
    • Liedmann S, Hrincius ER, Anhlan D, McCullers JA, Ludwig S, Ehrhardt C (2014) New virulence determinants contribute to the enhanced immune response and reduced virulence of an influenza A virus A/PR8/34 variant. J Infect Dis 209: 532-541.
    • Liedmann S, Hrincius ER, Guy C, Anhlan D, Dierkes R, Carter R, Wu G, Staeheli P, Green DR, Wolff T, McCullers JA, Ludwig S, Ehrhardt C (2014) Viral suppressors of the RIG-I-mediated interferon response are pre-packaged in influenza virions. Nature Comm 5: 5645.
    • Limmer S, Weiler A, Volkenhoff A, Babatz F, Klämbt C (2014) The Drosophila blood-brain barrier: development and function of a glial endothelium. Front Neurosci 8: 365. [Stefanie Schirmeier, neé Limmer]
    • Lubos M-L, Norkowski S, Stolle A-S, Langel Ü, Schmidt MA, Rüter C (2014) Analysis of T3SS-independent autonomous internalization of the bacterial effector protein SspH1 from Salmonella typhimurium. Inflammation & Cell Signaling 1: e423.
    • Momic T, Katzehendler J, Benny O, Lahiani A, Cohen G, Noy E, Senderowitz H, Eble JA, Marcinkiewicz C, Lazarovici P (2014) Vimocin and vidapin, cyclic KTS peptides, are dual antagonists of α1β1/α2β1 integrins with antiangiogenic activity. J Pharmacol Exp Ther 350: 506-519.
    • Musumeci L, Kuijpers MJ, Gilio K, Hego A, Théâtre E, Maurissen L, Vandereyken M, Diogo CV, Lecut C, Guilmain W, Bobkova EV, Rascon J, Eble JA, Dahl R, Drion P, Mostofi Y, Yuan H, Sergienko E, Chung TD, Thiry M, Senis Y, Moutschen M, Mustelin T, Lancellotti P, Heemskerk JW, Tautz L, Oury C, Rahmouni S (2015) DUSP3 phosphatase deficiency or inhibition limit platelet activation and arterial thrombosis. Circulation 131(7):656-668.
    • Nacken W, Anhlan D, Hrincius ER, Mostafa A, Wolff T, Sadewasser A, Pleschka S, Ehrhardt C, Ludwig S (2014) Activation of c-jun N-terminal kinase upon Influenza A Virus (IAV) infection is independent of pathogen related receptors, but dependent on amino acid sequence variations of the IAV NS1. J Virol, 88: 8843-8852.
    • Poeter M, Brandherm I, Rossaint J, Rosso G, Shahin V, Skryabin BV, Zarbock A, Gerke V, Rescher U (2014) Annexin A8 controls leukocyte recruitment to activated endothelial cells via cell surface delivery of CD63. Nat Commun 5: 3738.
    • Rüter C, Ruiz Silva M, Grabowski B, Lubos M-L, Scharnert J, Poceva M, von Tils D, Flieger A, Heesemann J, Bliska JB, Schmidt MA (2014) Rabbit monoclonal antibodies directed at the T3SS effector protein YopM identify human pathogenic Yersinia isolates. Int J Med Microbiol 304: 444–451.
    • Schmidt R, Nippe N, Strobel K, Masthoff M, Reifschneider O, Castelli DD, Höltke C, Aime S, Karst U, Sunderkötter C, Bremer C, Faber C (2014) Highly Shifted Proton MRI - Cell tracking by direct detction of paramagnetic compounds. Radiology 272(3): 785-795.
    • Schneider-Hohendorf T, Rossaint J, Mohan H, Böning D, Breuer J, Kuhlmann T, Gross CC, Flanagan K, Sorokin L, Vestweber D, Zarbock A, Schwab N, Wiendl H (2014) VLA-4 blockade promotes differential routes into human CNS involving PSGL-1 rolling of T cells and MCAM-adhesion of TH17 cells. J Exp Med 211 (9): 1833-1846.
    • Sreeramkumar V, Adrover JM, Ballesteros I, Cuartero MI, Rossaint J, Bilbao I, Nácher M, Pitaval C, Radovanovic I, Fukui Y, McEver RP, Filippi MD, Lizasoain I, Ruiz-Cabello J, Zarbock A, Moro MA, Hidalgo A (2014) Neutrophils scan for activated platelets to initiate inflammation. Science 346(6214): 1234-1238.
    • Vogl T, Eisenblätter M, Völler T, Zenker S, Hermann S, van Lent P, Faust A, Geyer C, Petersen B, Roebrock K, Schäfers M, Bremer C, Roth J (2014) Alarmin S100A8/S100A9 as a biomarker for molecular imaging of local inflammatory activity. Nat Commun 5: 4593.
    • Warnking K, Klemm C, Löffler B, Niemann S, van Krüchten A, Peters G, Ludwig S, Ehrhardt C (2015) Super-infection with Staphylococcus aureus inhibits influenza virus-induced type I IFN signalling through impaired STAT1-STAT2 dimerization. Cell Microbiol 17(3):303-317.
  • Publications 2013

    • Bielaszewska M, Rüter C, Kunsmann L, Greune L, Bauwens A, Zhang W, Kuczius T, Kim KS, Mellmann A, Schmidt MA, Karch H (2013) Enterohemorrhagic Escherichia coli hemolysin employs outer membrane vesicles to target mitochondria and cause endothelial and epithelial apoptosis. PLoS Pathog 9: e1003797.
    • Bittner S, Ruck T, Schuhmann MK, Herrmann AM, Moha ou Maati H, Bobak N, Göbel K, Langhauser F, Stegner D, Ehling P, Borsotto M, Pape HC, Nieswandt B, Kleinschnitz C, Heurteaux C, Galla HJ, Budde T, Wiendl H, Meuth SG (2013) Endothelial TWIK-related potassium channel-1 (TREK1) regulates immune-cell trafficking into the CNS. Nature Med 19 (9): 1161-1169.
    • Foell D, Wittkowski H, Kessel C, Lüken A, Weinhage T, Varga G, Vogl T, Wirth T, Viemann D, Björk P, van Zoelen MAD, Gohar F, Srikrishna G, Kraft M, Roth J (2013) Pro-inflammatory S100A12 can activate human monocytes via Toll-like Receptor 4. Am J Respir Crit Care Med 187: 1324-1334.
    • Ghavampour S, Lange C, Bottino C, Gerke V (2013) Transcriptional profiling of human monocytes identifies the inhibitory receptor CD300a as regulator of transendothelial migration. PLOS One 8 (9): e73981.
    • Gopal R, Monin L, Torres D, Slight S, Mehra S, McKenna K, Fallert-Junecko BA, Reinhart TA, Kolls J, Báez-Saldaña R, Cruz-Lagunas A, Rodríguez-Reyna TS, Kumar NP, Tessier P, Roth J, Selman M, Becerril-Villanueva E, Baquera-Heredia J, Cumming B, Kasprowicz VO, Steyn AJ, Babu S, Kaushal D, Zúñiga J, Vogl T, Rangel-Moreno J, Khader SA (2013) S100A8/A9 proteins mediate neutrophilic inflammation and lung pathology during tuberculosis. Am J Respir Crit Care Med 188: 1137-1146.
    • Herter JM, Rossaint J, Block H, Welch H, Zarbock A (2013) Integrin activation by P-Rex1 is required for selectin-mediated slow leukocyte rolling and intravascular crawling. Blood 121(12): 2301-2310.
    • Hoerr V, Tuchscherr L, Hüve J, Nippe N, Loser K, Glyvuk N, Tsytsyura Y, Holtkamp M, Sunderkötter C, Karst U, Klingauf J, Peters G, Löffler B, Faber C (2013) Bacteria tracking by in vivo magnetic resonance imaging. BMC Biol 11: 63. [doi: 10.1186/1741-7007-11-63]
    • Kuipers MT*, Vogl T*, Aslami H, Jongsma G, van den Berg E, Vlaar APJ, Roelofs JJTH, Juffermans NP, Schultz MJ, van der Poll T, Roth J, Wieland CW (2013) High levels of S100A8/A9 proteins aggravate ventilator-induced lung injury via TLR4 signaling. PLoS One 8: e68694. [IF: 3.73] * Both authors made equal contributions.
    • Löffler B, Niemann S, Ehrhardt C, Horn D, Lanckohr C, Lina G, Ludwig S, Peters G (2013) Pathogenesis of Staphylococcus aureus necrotizing pneumonia: the role of PVL and an influenza coinfection. Expert Rev Anti Infect Ther 11: 1041-1051.
    • Michaelis UR, Chavakis E, Kruse C, Jungblut B, Kaluza D, Wandzioch K, Manavski Y, Heide H, Santoni MJ, Potente M, Eble JA, Borg JP, Brandes RP (2013) The polarity protein Scrib is essential for directed endothelial cell migration. Circ Res 112: 924-934.
    • Musiol A, Gran S, Ehrhardt C, Ludwig S, Grewal T, Gerke V, Rescher U (2013) Annexin A6-balanced late endosomal cholesterol controls Influenza A replication and propagation. MBio 4(6): e00608-13.
    • Nikolic I, Stankovic ND, Bicker F, Meister J, Braun H, Awwad K, Baumgart J, Simon K, Thal SC, Patra C, Harter PN, Plate KH, Engel FB, Dimmeler S, Eble JA, Mittelbronn M, Schafer MK, Jungblut B, Chavakis E, Fleming I, Schmidt MH (2013) EGFL7 ligates αvβ3 integrin to enhance vessel formation. Blood 121: 3041-3050.
    • Niland S, Ditkowski B, Parrandier D, Roth L, Augustin H, Eble JA (2013) Rhodocetin-αβ-induced neuropilin-1-cMet association triggers restructuring of matrix contacts in endothelial cells. Arterioscler Thromb Vasc Biol 33: 544-554.
    • Petersen B, Wolf M, Austermann J, van Lent PLEM, Foell D, Ahlmann M, Kupas V, Loser K, Sorg C, Roth J, Vogl T(2013) The alarmin Mrp8/14 as regulator of the adaptive immune response during allergic contact dermatitis. EMBO J 32: 100-111. [IF: 9.82]
    • Revelles O, Millard P, Nougayrède J-P, Dobrindt U, Oswald E, Létisse F, Portais J-C (2013) The Carbon storage regulator (Csr) system exerts a nutrient-specific control over central metabolism in Escherichia coli strain Nissle 1917. PLoS One 8: e66386.
    • Retser E, Schied T, Skryabin BV, Vogl T, Kanczler JM, Hamann N, Niehoff A, Hermann S, Eisenblätter M, Wachsmuth L, Pap T, van Lent PL, Loser K, Roth J, Zaucke F, Ludwig S, Wixler V. (2013) Doxycycline-induced expression of transgenic human tumor necrosis factor α in adult mice results in psoriasislike arthritis. Arthritis Rheum. 65(9):2290-300
    • Rüter C, Hardwidge PR (2013) 'Drugs from Bugs': bacterial effector proteins as promising biological (immune-) therapeutics. FEMS Microbiol Lett 351: 126-132. (cover)
    • Seelige R, Natsch C, März S, Jing D, Frye M, Butz S, Vestweber D (2013) Cutting edge: Endothelial-specific gene ablation of CD99L2 impairs leukocyte extravasation in vivo. J Immunol 190: 892-896.
    • Song J, Wu C, Zhang X, Sorokin L (2013) In vivo processing of CXCL5 (LIX) by matrix metalloproteinase (MMP)-2 and MMP-9 promotes early neutrophil recruitment in IL-1β-induced peritonitis. J Immunol 190: 401-410.
    • Sváb D, Horváth B, Maróti G, Dobrindt U, Tóth I (2013) Sequence variability of P2-like prophage genomes carrying the cytolethal distending toxin V operon in Escherichia coli O157. Appl Environ Microbiol 79: 4958-4964.
    • Zhang X, Wu C, Jian Song, Götte M, Sorokin L (2013) Syndecan-1, a cell surface proteoglycan, negatively regulates initial leukocyte recruitment to the brain across the choroid plexus in murine experimental autoimmune encephalomyelitis. J Immunol 191: 4551-4561.
    • Publications 2012

      • Holzinger D, Gieldon L, Mysore V, Nippe N, Taxman D, Duncan JA, Broglie PM, Marketon K, Austermann J, Vogl T, Foell D, Niemann S, Peters G, Roth J, Löffler B (2012) Staphylococcus aureus Panton-Valentine leukocidin induces an inflammatory response in human phagocytes via the NLRP3 inflammasome. J Leukoc Biol 92: 1069-1081.
      • Kusuma N, Denoyer D, Eble JA, Redvers RP, Parker BS, Pelzer R, Anderson RL, Pouliot N (2012) Integrindependent response to laminin-511 regulates breast tumor cell invasion and metastasis. Int J Cancer 130: 555-566.
      • Nacken W, Ehrhardt C, Ludwig S (2012) Small molecule inhibitors of the c-Jun N-terminal kinase (JNK) possess antiviral activity against highly pathogenic avian and human pandemic influenza A viruses. Biol Chem 393: 525-534.
      • Niemann S, Ehrhardt C, Medina E, Warnking K, Tuchscherr L, Heitmann V, Ludwig S, Peters GLöffler B. Combined action of influenza virus and Staphylococcus aureus panton-valentine leukocidin provokes severe lung epithelium damage. J Infect Dis 206(7): 1138-1148.
      • Niland S, Eble JA (2012) Integrin-mediated cell-matrix interaction in physiological and pathological blood vessel formation. J Oncol 2012: 125278.
      • Rossaint J, Berger C, Van Aken H, Scheld HH, Zahn PK, Rukosujew A, Zarbock A (2012) Cardiopulmonary bypass during cardiac surgery modulates systemic inflammation by affecting different steps of the leukocyte recruitment cascade. PLoS One 7(9): e45738.

      • Book article

        • Dejana E, Vestweber D (2013) The Role of VE-cadherin in Vascular Morphogenesis and Permeability Control. In: The Molecular Biology of Cadherins. F. v. Roy, ed Elsevier, 116: 119-144.
        Grafik © Raphael Fehrmann