
© U. Dobrindt
We aim at the identification of bacterial properties and the molecular mechanisms involved in different types of host-bacterium interaction at cellular barriers leading to infection or colonization. We want to unravel how bacteria downregulate RNA polymerase II and c-MYC-dependent host gene expression. We also want to understand how epigenetic mechanisms, like histone acetylation and DNA methylation, reprogramme innate immunity during infection with uropathogenic E. coli.
Research area: Bacterial genetics, infection biology
Prof. Dr. rer. nat. Ulrich Dobrindt
Funding period: July 2012 - June 2024
Original articles