Research area: Leukocyte biology, endothelial cell biology
Funding period: July 2012 - June 2020
Formyl peptide chemoattractant receptors in leukocyte activation and trans-endothelial migration
Leukocyte extravasation is subject to tight control and requires a delicate balance between pro- and anti-inflammatory signals for the correct initiation and termination of leukocyte activation and migration. In this project, we identify and characterize endogenous factors that control the extent of inflammatory leukocyte activation. A focus is on the anti-inflammatory protein Annexin A1 and its receptors of the formyl peptide receptor (FPR) family.