
© I. Kuzmanov
Our project investigates mechanisms how lymphocytes breach the blood-brain-barrier and contribute to CNS inflammation. In the first part, we aim to reveal the key influencing factors as well as underlying mechanisms of immune cell-mediated brain endothelial barrier disruption under static and under flow conditions. In the second part, we aim to study the role of pericytes as cellular constituents of the blood-brain-barrier during the process of immune cell transmigration in the context of CNS autoimmunity, especially with regard to potential interactions with autoreactive T cells shaping T cell activity and migratory behaviour.
Research area: Neuroimmunology
Prof. Dr. med. Heinz Wiendl
Prof. Dr. med. Luisa Klotz (since 07/2016)
Funding period: July 2012 - June 2024
Original articles
Reviews