Analysis of the Drosophila blood brain barrier
We will focus our efforts on understanding the formation and maintenance of septate junctions that are essential for establishing a functional blood-brain barrier. In particular, we aim to unravel the relevance of tri-cellular junctions. We will analyse how the lateral growth of septate junctions is organized during larval stages and how cell polarity is established and maintained in the glial cells that form the blood-brain barrier. In a second step, we will address the contribution of tri-cellular junctions to the penetration of macrophages that are attracted by tissue damage within the brain.
- Sara Caviglia, David Flores-Benitez, Johanna Lattner, Stefan Luschnig & Marko Brankatschk (2017) Rabs on the fly: Functions of Rab GTPases during development, Small GTPases. (doi: 10.1080/21541248.2017.1279725)
- Tvisha Misra, Martin Baccino-Calace, Felix Meyenhofer, David Rodriguez-Crespo, Hatice Akarsu, Ricardo Armenta-Calderón, Thomas A. Gorr, Christian Frei, Rafael Cantera, Boris Egger, Stefan Luschnig (2017) A genetically encoded biosensor for visualising hypoxia responses in vivo. Biology Open 6: 296-304. (doi: 10.1242/bio.018226)
- Matzat T, Sieglitz F, Kottmeier R, Babatz F, Engelen D, Klämbt C (2015) Axonal wrapping in the Drosophila PNS is controlled by glia-derived neuregulin homolog Vein. Development 142: 1336-1345.
- Volkenhoff A, Weiler A, Letzel M, Stehling M, Klämbt C, Schirmeier S (2015) Glial glycolysis is essential for neuronal survival in Drosophila. Cell Metab 22: 437-447.
- Limmer S, Weiler A, Volkenhoff A, Babatz F, Klämbt C (2014) The Drosophila blood-brain barrier: development and function of a glial endothelium. Front Neurosci 8: 365. [Stefanie Schirmeier, neé Limmer]
- Schirmeier S, Matzat T, Klämbt C (2016) Axon ensheathment and metabolic supply by glial cells in Drosophila. Brain Res 1641(Pt A): 122-129. (doi: 10.1016/j.brainres.2015.09.003. Epub 2015 Sep 12.)