Research area: Matrix biology, immunology
Funding period: July 2012 - June 2020
Mechanisms of leukocyte penetration of vascular cell basement membranes
Laminin isoform composition (laminins 411 and 511) of endothelial basement membranes defines sites of leukocyte extravasation. Laminins can directly affect immune cell migration but can also effect the expression (CD99L2) and localization of endothelial junctional molecules (VE-cadherin) involved in paracellular migration. Signal cascades induced by laminins 411 and 511 in different immune cell populations will be studied and how this affects their migratory behaviours, and molecular mechanisms of laminin 511 affects on endothelial adhesion molecule expression and/or function.
Prof. Dr. (PhD) Lydia Sorokin
Institute of Physiological Chemistry and Pathobiochemistry
Tel: +49 (0) 251 83 55518
Principal investigator: A 02