The role of the Rab7 GTPase in podocyte function
An imbalance between endocytosis and autophagy plays a key role in the pathogenesis of kidney diseases. We hypothesize that late endolysosomal transport plays specific roles in podocyte function. To test this, we knocked out the GTPase Rab7 — a key enzyme involved in late endo- and autolysosomal trafficking — specifically in mouse podocytes. These podocyte-specific Rab7 knockout mice develop severe podocyte injury and proteinuria.
Using cell biological techniques, we aim to elucidate the mechanisms that lead to the development of podocytopathy. This project will provide critical insights into the role of late endolysosomal trafficking in maintaining podocyte function.