• Membrane Remodeling by a Bacterial Phospholipid-Methylating Enzyme.
  Danne L, Aktas M, Unger A, Linke WA, Erdmann R, Narberhaus F , MBio. (2017) , 8(1)
• Defined Engineered Human Myocardium with Advanced Maturation for Applications in Heart Failure Modelling and Repair
  Tiburcy M, Hudson JE, Balfanz P, Schlick SF, Meyer T, Chang Liao ML, Levent E, Raad F, Zeidler S, Wingender E, Riegler J, Wang M, Gold JD, Kehat I, Wettwer E, Ravens U, Dierickx P, van Laake L, Goumans MJ, Khadjeh S, Toischer K, Hasenfuss G, Couture LA, Unger A, Linke WA, Araki T, Neel B, Keller G, Gepstein L, Wu JC, Zimmermann WH , Circulation. (2017) : [Epub ahead of print]
• Titin-truncating variants affect heart function in disease cohorts and the general population.
  Schafer S, de Marvao A, Adami E, Fiedler LR, Ng B, Khin E, Rackham OJ, van Heesch S, Pua CJ, Kui M, Walsh R, Tayal U, Prasad SK, Dawes TJ, Ko NS, Sim D, Chan LL, Chin CW, Mazzarotto F, Barton PJ, Kreuchwig F, de Kleijn DP, Totman T, Biffi C, Tee N, Rueckert D, Schneider V, Faber A, Regitz-Zagrosek V, Seidman JG, Seidman CE, Linke WA, Kovalik JP, O'Regan D, Ware JS, Hubner N, Cook SA , Nat Genet. (2017) , 49(1) : 46-53

• Cardioprotection and lifespan extension by the natural polyamine spermidine.
  Eisenberg T, Abdellatif M, Schroeder S, Primessnig U, Stekovic S, Pendl T, Harger A, Schipke J, Zimmermann A, Schmidt A, Tong M, Ruckenstuhl C, Dammbrueck C, Gross AS, Herbst V, Magnes C, Trausinger G, Narath S, Meinitzer A, Hu Z, Kirsch A, Eller K, Carmona-Gutierrez D, Büttner S, Pietrocola F, Knittelfelder O, Schrepfer E, Rockenfeller P, Simonini C, Rahn A, Horsch M, Moreth K, Beckers J, Fuchs H, Gailus-Durner V, Neff F, Janik D, Rathkolb B, Rozman J, de Angelis MH, Moustafa T, Haemmerle G, Mayr M, Willeit P, von Frieling-Salewsky M, Pieske B, Scorrano L, Pieber T, Pechlaner R, Willeit J, Sigrist SJ, Linke WA, Mühlfeld C, Sadoshima J, Dengjel J, Kiechl S, Kroemer G, Sedej S, Madeo F. , Nat Med. (2016) , 22(12) : 1428-1438
• Expanding the phenotype of BICD2 mutations toward skeletal muscle involvement.
  Unger A, Dekomien G, Güttsches A, Dreps T, Kley R, Tegenthoff M, Ferbert A, Weis J, Heyer C, Linke WA, Martinez-Carrera L, Storbeck M, Wirth B, Hoffjan S, Vorgerd M. , Neurology. (2016) , 87(21) : 2235-2243
• Left Atrial Remodeling and Atrioventricular Coupling in a Canine Model of Early Heart Failure With Preserved Ejection Fraction.
  Zakeri R, Moulay G, Chai Q, Ogut O, Hussain S, Takahama H, Lu T, Wang XL, Linke WA, Lee HC, Redfield MM. , Circ Heart Fail. (2016) , 9(10)
• Sphingosine-1-Phosphate Receptor 1 Regulates Cardiac Function by Modulating Ca2+ Sensitivity and Na+/H+ Exchange and Mediates Protection by Ischemic Preconditioning.
  Keul P, van Borren MM, Ghanem A, Müller FU, Baartscheer A, Verkerk AO, Stümpel F, Schulte JS, Hamdani N, Linke WA, van Loenen P, Matus M, Schmitz W, Stypmann J, Tiemann K, Ravesloot JH, Alewijnse AE, Hermann S, Spijkers LJ, Hiller KH, Herr D, Heusch G, Schäfers M, Peters SL, Chun J, Levkau B. , J Am Heart Assoc. (2016) , 5(5)
• Titin stiffness modifies the force-generating region of muscle sarcomeres.
  Li Y, Lang P, Linke WA. , Sci Rep. (2016) , 6 : 24492
• Work Done by Titin Protein Folding Assists Muscle Contraction.
  Rivas-Pardo JA, Eckels EC, Popa I, Kosuri P, Linke WA, Fernández JM. , Cell Rep. (2016) , 14(6) : 1339-1347
• Functional characterization of the novel DES mutation p.L136P associated with dilated cardiomyopathy reveals a dominant filament assembly defect.
  Brodehl A, Dieding M, Biere N, Unger A, Klauke B, Walhorn V, Gummert J, Schulz U, Linke WA, Gerull B, Vorgert M, Anselmetti D, Milting H , J Mol Cell Cardiol. (2015) , 91 : 207-214
• Cardiac contractility modulation signals improve exercise intolerance and maladaptive regulation of cardiac key proteins for systolic and diastolic function in HFpEF.
  Tschöpe C, Van Linthout S, Spillmann F, Klein O, Biewener S, Remppis A, Gutterman D, Linke WA, Pieske B, Hamdani N, Roser M. , Int J Cardiol. (2016) , 203 : 1061-1066
• Molecular and structural transition mechanisms in long-term volume overload.
  Mohamed BA, Schnelle M, Khadjeh S, Lbik D, Herwig M, Linke WA, Hasenfuss G, Toischer K. , Eur J Heart Fail. (2016) , 18(4) : 362-71

• Myocardial Microvascular Inflammatory Endothelial Activation in Heart Failure With Preserved Ejection Fraction.
  Franssen C, Chen S, Unger A, Korkmaz HI, De Keulenaer GW, Tschöpe C, Leite-Moreira AF, Musters R, Niessen HW, Linke WA, Paulus WJ, Hamdani N. , JACC Heart Fail. (2015) , 4(4) : 312-24
• Myofibrillar instability exacerbated by acute exercise in filaminopathy.
  Chevessier F, Schuld J, Orfanos Z, Plank AC, Wolf L, Maerkens A, Unger A, Schlötzer-Schrehardt U, Kley RA, von Hörsten S, Marcus K, Linke WA, Vorgerd M, van der Ven PF, Fürst DO, Schröder R. , Hum Mol Genet. (2015) , 24(25) : 7207-20
• A porcine model of hypertensive cardiomyopathy: implications for heart failure with preserved ejection fraction.
  Schwarzl M, Hamdani N, Seiler S, Alogna A, Manninger M, Reilly S, Zirngast B, Kirsch AH, Steendijk P, Verderber J, Zweiker D, Eller P, Hoefler G, Schauer S, Eller K, Maechler H, Pieske B, Linke WA, Casadei B, Post H. , Am J Physiol Heart Circ Physiol. (2015) , 309(9) : H1407-18
• HEART DISEASE. Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy.
  Hinson JT, Chopra A, Nafissi N, Polacheck WJ, Benson CC, Swist S, Gorham J, Yang L, Schafer S, Sheng CC, Haghighi A, Homsy J, Hubner N, Church G, Cook SA, Linke WA, Chen CS, Seidman JG, Seidman CE. , Science (2015) , 349 : 982-986
• Syndecan-4 is a key determinant of collagen cross-linking and passive myocardial stiffness in the pressure-overloaded heart.
  Herum KM, Lunde IG, Skrbic B, Louch WE, Hasic A, Boye S, Unger A, Brorson SH, Sjaastad I, Tønnessen T, Linke WA, Gomez MF, Christensen G. , Cardiovasc Res. (2015) , 106(2) : 217-26
• Emerging importance of oxidative stress in regulating striated muscle elasticity.
  Beckendorf L, Linke WA. , J Muscle Res Cell Motil. (2015) , 36(1) : 25-36

• FHL2 expression and variants in hypertrophic cardiomyopathy.
  Friedrich FW, Reischmann S, Schwalm A, Unger A, Ramanujam D, Münch J, Müller OJ, Hengstenberg C, Galve E, Charron P, Linke WA, Engelhardt S, Patten M, Richard P, van der Velden J, Eschenhagen T, Isnard R, Carrier L. , Basic Res Cardiol. (2014) , 109(6) : 451
• Interleukin-6 receptor inhibition modulates the immune reaction and restores titin phosphorylation in experimental myocarditis.
  Savvatis K, Müller I, Fröhlich M, Pappritz K, Zietsch C, Hamdani N, Grote K, Schieffer B, Klingel K, Van Linthout S, Linke WA, Schultheiss HP, Tschöpe C. , Basic Res Cardiol. (2014) , 109(6) : 449
• Left ventricular diastolic dysfunction and myocardial stiffness in diabetic mice is attenuated by inhibition of dipeptidyl peptidase 4.
  Hamdani N, Hervent AS, Vandekerckhove L, Matheeussen V, Demolder M, Baerts L, De Meester I, Linke WA, Paulus WJ, De Keulenaer GW , Cardiovasc Res. (2014) , 104(3) : 423-31
• Heart failure with preserved ejection fraction.
  Gladden JD, Linke WA, Redfield MM. , Pflugers Arch. (2014) , 466(6) : 1037-53
• S-glutathionylation of cryptic cysteines enhances titin elasticity by blocking protein folding.
  Alegre-Cebollada J, Kosuri P, Giganti D, Eckels E, Rivas-Pardo JA, Hamdani N, Warren CM, Solaro RJ, Linke WA, Fernández JM. , Cell. (2014) , 156(6) : 1235-46
• Gigantic business: titin properties and function through thick and thin.
  Linke WA, Hamdani N. , Circ Res. (2014) , 114(6) : 1052-68
• Meeting highlights from the 2013 European Society of Cardiology Heart Failure Association Winter Meeting on Translational Heart Failure Research.
  Hohl M, Ardehali H, Azuaje FJ, Breckenridge RA, Doehner W, Eaton P, Ehret GB, Fujita T, Gaetani R, Giacca M, Hasenfuß G, Heymans S, Leite-Moreira AF, Linke WA, Linz D, Lyon A, Mamas MA, Orešič M, Papp Z, Pedrazzini T, Piepoli M, Prosser B, Rizzuto R, Tarone G, Tian R, van Craenenbroeck E, van Rooij E, Wai T, Weiss G, Maack C. , Eur J Heart Fail. (2014) , 16(1) : 6-14
• Human myocytes are protected from titin aggregation-induced stiffening by small heat shock proteins.
  Kötter S, Unger A, Hamdani N, Lang P, Vorgerd M, Nagel-Steger L, Linke WA. , J Cell Biol. (2014) , 204(2) : 187-202

• Myocardial Titin Hypophosphorylation Importantly Contributes to Heart Failure with Preserved Ejection Fraction in a Rat Metabolic Risk Model.
  Hamdani N, Franssen C, Lourenço A, Falcão-Pires I, Fontoura D, Leite S, Plettig L, López B, Ottenheijm CA, Becher MP, González A, Tschöpe C, Díez J, Linke WA, Leite-Moreira AF, Paulus WJ. , Circ Heart Fail. (2013) : [Epub ahead of print]
• Mena/VASP and alphaII-Spectrin complexes regulate cytoplasmic actin networks in cardiomyocytes and protect from conduction abnormalities and dilated cardiomyopathy.
  Benz PM, Merkel CJ, Offner K, Abeßer M, Ullrich M, Fischer T, Bayer B, Wagner H, Gambaryan S, Ursitti JA, Adham IM, Linke WA, Feller SM, Fleming I, Renné T, Frantz S, Unger A, Schuh K. , Cell Commun Signal. (2013) , 11(1) : 56
• Untangling regulatory networks to spot drivers and modulators of cardiac disease.
  Swist S, Linke WA. , J Mol Cell Cardiol. (2013) , 63C : 1-3
• Differential changes in titin domain phosphorylation increase myofilament stiffness in failing human hearts.
  Kötter S, Gout L, Von Frieling-Salewsky M, Müller AE, Helling S, Marcus K, Dos Remedios C, Linke WA, Krüger M. , Cardiovasc Res. (2013) , 99(4) : 648-56
• 7th Ascona International Workshop on Cardiomyocyte Biology: Cardiac pathways of differentiation, metabolism and contraction.
  Linke WA, Schaub MC. , Biochim Biophys Acta. (2013) , 1833(4) : 781-2
• Crucial Role for Ca²⁺/Calmodulin-Dependent Protein Kinase-II in Regulating Diastolic Stress of Normal and Failing Hearts via Titin Phosphorylation.
  Hamdani N, Krysiak J, Kreusser MM, Neef S, Dos Remedios CG, Maier LS, Krüger M, Backs J, Linke WA. , Circ Res. (2013) , 112(4) : 664-74
• Deranged Myofilament Phosphorylation and Function in Experimental Heart Failure with Preserved Ejection Fraction.
  Hamdani N, Bishu KG, von Frieling-Salewsky M, Redfield MM, Linke WA. , Cardiovasc Res. (2013) , 97(3) : 464-71
• Lysine methyltransferase Smyd2 regulates Hsp90-mediated protection of the sarcomeric titin springs and cardiac function.
  Voelkel T, Andresen C, Unger A, Just S, Rottbauer W, Linke WA , Biochim Biophys Acta. (2013) , 1833(4) : 812-22

• King of hearts: a splicing factor rules cardiac proteins.
  Linke WA, Bücker S. , Nat Med. (2012) , 18(5) : 660-1
• Evidence for FHL1 as a novel disease gene for isolated hypertrophic cardiomyopathy.
  Friedrich FW, Wilding BR, Reischmann S, Crocini C, Lang P, Charron P, Müller OJ, McGrath MJ, Vollert I, Hansen A, Linke WA, Hengstenberg C, Bonne G, Morner S, Wichter T, Madeira H, Arbustini E, Eschenhagen T, Mitchell CA, Isnard R, Carrier L. , Hum Mol Genet. (2012) , 21(14) : 3237-54
• Age-dependent changes in contractile function and passive elastic properties of myocardium from mice lacking muscle LIM protein (MLP).
  Unsöld B, Schotola H, Jacobshagen C, Seidler T, Sossalla S, Emons J, Klede S, Knöll R, Guan K, El-Armouche A, Linke WA, Kögler H, Hasenfuss G. , Eur J Heart Fail. (2012) , 14(4) : 430-7
• Alteration of the beta-adrenergic signaling pathway in human heart failure.
  Hamdani N, Linke WA. , Curr Pharm Biotechnol. (2012) : Jan 20. [Epub ahead of print]
• Smyd2 controls cytoplasmic lysine methylation of Hsp90 and myofilament organization.
  Donlin LT, Andresen C, Just S, Rudensky E, Pappas CT, Kruger M, Jacobs EY, Unger A, Zieseniss A, Dobenecker MW, Voelkel T, Chait BT, Gregorio CC, Rottbauer W, Tarakhovsky A, Linke WA. , Genes Dev. (2012) , 26(2) : 114-9

• Sildenafil and B-type natriuretic Peptide acutely phosphorylate titin and improve diastolic distensibility in vivo.
  Bishu K, Hamdani N, Mohammed SF, Kruger M, Ohtani T, Ogut O, Brozovich FV, Burnett JC Jr, Linke WA, Redfield MM. , Circulation (2011) , 124(25) : 2882-91
• Transmural heterogeneity of myofilament function and sarcomeric protein phosphorylation in remodeled myocardium of pigs with a recent myocardial infarction.
  van der Velden J, Merkus D, de Beer V, Hamdani N, Linke WA, Boontje NM, Stienen GJ, Duncker DJ. , Front Physiol. (2011) , 2 : Article 83
• Terminal differentiation, advanced organotypic maturation, and modeling of hypertrophic growth in engineered heart tissue.
  Tiburcy M, Didié M, Boy O, Christalla P, Döker S, Naito H, Karikkineth BC, El-Armouche A, Grimm M, Nose M, Eschenhagen T, Zieseniss A, Katschinksi DM, Hamdani N, Linke WA, Yin X, Mayr M, Zimmermann WH. , Circ Res. (2011) , 109(10) : 1105-14
• Telethonin Deficiency Is Associated With Maladaptation to Biomechanical Stress in the Mammalian Heart.
  Knöll R, Linke WA, Zou P, Miocic S, Kostin S, Buyandelger B, Ku CH, Neef S, Bug M, Schäfer K, Knöll G, Felkin LE, Wessels J, Toischer K, Hagn F, Kessler H, Didié M, Quentin T, Maier LS, Teucher N, Unsöld B, Schmidt A, Birks EJ, Gunkel S, Lang P, Granzier H, Zimmermann WH, Field LJ, Faulkner G, Dobbelstein M, Barton PJ, Sattler M, Wilmanns M, Chien KR , Circ Res. (2011) , 109(7) : 758-69
• Conformation-regulated mechanosensory control via titin domains in cardiac muscle.
  Voelkel T, Linke WA. , Pflugers Arch. (2011) , 462(1) : 143-54
• The giant protein titin: a regulatory node that integrates myocyte signaling pathways.
  Krüger M, Linke WA , J Biol Chem. (2011) , 286(12) : 9905-12 (Review)

• Modulation of Human Ether A Gogo Related Channels by CASQ2 Contributes to Etiology of Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)
  Eckey K, Strutz-Seebohm N, Katz G, Fuhrmann G, Henrion U, Pott L, Linke WA, Arad M, Lang F, Seebohm G , Cell Physiol Biochem (2010) , 26(4-5) : 503-12
• Molecular Giant Vulnerable to Oxidative Damage. Titin Joins the Club of Proteins Degraded by Matrix Metalloproteinase-2
  Linke WA , Circulation (2010) , 122(20) : 2002-4
• Biomaterials: spider strength and stretchability
  Linke WA , Nat Chem Biol (2010) , 6(10) : 702-3
• Treatment of heart failure with normal ejection fraction.
  Hamdani N, Paulus WJ. , Curr Treat Options Cardiovasc Med. (2011) , 13(1) : 26-34
• Differential cardiac remodeling in preload versus afterload
  Toischer K, Rokita AG, Unsöld B, Zhu W, Kararigas G, Sossalla S, Reuter SP, Becker A, Teucher N, Seidler T, Grebe C, Preuss L, Gupta SN, Schmidt K, Lehnart SE, Krüger M, Linke WA, Backs J, Regitz-Zagrosek V, Schäfer K, Field LJ, Maier LS, Hasenfuss G , Circulation (2010) , 122(10) : 993-1003
• Multiple potential molecular contributors to atrial hypocontractility caused by atrial tachycardia remodeling in dogs
  Wakili R, Yeh YH, Yan Qi X, Greiser M, Chartier D, Nishida K, Maguy A, Villeneuve LR, Boknik P, Voigt N, Krysiak J, Kääb S, Ravens U, Linke WA, Stienen GJ, Shi Y, Tardif JC, Schotten U, Dobrev D, Nattel S , Circ Arrhythm Electrophysiol (2010) , 3(5) : 530-41
• The giant protein titin as an integrator of myocyte signaling pathways
  Linke WA, Krüger M , Physiology (Bethesda) (2010) , 25(3) : 186-98 (Review)
• Insulin signaling regulates cardiac titin properties in heart development and diabetic cardiomyopathy
  Krüger M, Babicz K, von Frieling-Salewsky M, Linke WA , J Mol Cell Cardiol (2010) , 48(5) : 910-16
• Regulation of oscillatory contraction in insect flight muscle by troponin
  Krzic U, Rybin V, Leonard KR, Linke WA, Bullard B , J Mol Biol (2010) , 397(1) : 110-18
• A common MLP (muscle LIM protein) variant is associated with cardiomyopathy
  Knöll R, Kostin S, Klede S, Savvatis K, Klinge L, Stehle I, Gunkel S, Kötter S, Babicz K, Sohns M, Miocic S, Didié M, Knöll G, Zimmermann WH, Thelen P, Bickeböller H, Maier LS, Schaper W, Schaper J, Kraft T, Tschöpe C, Linke WA, Chien KR , Circ Res (2010) , 106(4) : 695-704

• Prevention of myofilament dysfunction by beta-blocker therapy in postinfarct remodeling
  Duncker DJ, Boontje NM, Merkus D, Versteilen A, Krysiak J, Mearini G, El-Armouche A, de Beer VJ, Lamers JM, Carrier L, Walker LA, Linke WA, Stienen GJ, van der Velden J , Circ Heart Fail (2009) , 2(3) : 233-42
• Modulation of titin-based stiffness by disulfide bonding in the cardiac titin N2-B unique sequence
  Grützner A, Garcia-Manyes S, Kötter S, Badilla CL, Fernandez JM, Linke WA , Biophys J (2009) , 97(3) : 825-34
• Titin-based mechanical signalling in normal and failing myocardium
  Krüger M, Linke WA , J Mol Cell Cardiol (2009) , 46(4) : 490-8 (Review)
• Titin and titin-associated proteins in myocardial stress-sensing and mechanical dysfunction
  Linke WA , Mechanosensitivity in cells and tissues, Mechanosensitivity of the heart (A. Kamkin & Kiseleva, I., Eds.) Springer, Heidelberg 4 (2009) : (Review)
• Functional role of the extended loop 2 in the myosin 9b head for binding F-actin
  Struchholz S, Elfrink K, Pieper U, Kalhammer G, Honnert U, Grützner A, Linke WA, Liao W, Bähler M , J Biol Chem (2009) , 284(6) : 3663-71
• Protein kinase G modulates human myocardial passive stiffness by phosphorylation of the titin springs
  Krüger M, Kötter S, Grützner A, Lang P, Andresen C, Redfield MM, Butt E, dos Remedios CG, Linke WA , Circ Res (2009) , 104(1) : 87-94

• Titin isoforms, extracellular matrix, and global chamber remodeling in experimental dilated cardiomyopathy: functional implications and mechanistic insight
  Jaber WA, Maniu C, Krysiak J, Shapiro BP, Meyer DM, Linke WA, Redfield MM , Circ Heart Fail (2008) , 1(3) : 192-9
• Thyroid hormone regulates developmental titin isoform transitions via the phosphatidylinositol-3-kinase/ AKT pathway
  Krüger M, Sachse C, Zimmermann WH, Eschenhagen T, Klede S, Linke WA , Circ Res (2008) , 102(4) : 439-47
• Mineralocorticoid signaling in transition to heart failure with normal ejection fraction
  Shapiro BP, Owan TE, Mohammed S, Kruger M, Linke WA, Burnett JC Jr, Redfield MM , Hypertension (2008) , 51(2) : 289-95
• Pulling single molecules of titin by AFM--recent advances and physiological implications
  Linke WA, Grützner A , Pflugers Arch (2008) , 456(1) : 101-15 (Review)
• Sense and stretchability: the role of titin and titin-associated proteins in myocardial stress-sensing and mechanical dysfunction
  Linke WA , Cardiovasc Res (2008) , 77(4) : 637-48 (Review)
• Taschenatlas Physiologie (Lehrbuch)
  Fahlke/Linke/Rassler/Wiesner (Eds) , Elsevier (2008) , 1. Auflage

• Acute and chronic ventricular-arterial coupling in systole and diastole: insights from an elderly hypertensive model
  Shapiro BP, Lam CS, Patel JB, Mohammed SF, Kruger M, Meyer DM, Linke WA, Redfield MM , Hypertension (2007) , 50(3) : 503-11

• Fibre type-specific increase in passive muscle tension in spinal cord-injured subjects with spasticity
  Olsson MC, Krüger M, Meyer LH, Ahnlund L, Gransberg L, Linke WA, Larsson L , J Physiol (2006) , 577(Pt 1) : 339-52
• Protein kinase-A phosphorylates titin in human heart muscle and reduces myofibrillar passive tension
  Krüger M, Linke WA , J Muscle Res Cell Motil (2006) , 27(5-7) : 435-44
• Mechanical properties of cardiac titin's N2B-region by single-molecule atomic force spectroscopy
  Leake MC, Grützner A, Krüger M, Linke WA , J Struct Biol (2006) , 155(2) : 263-72
• Developmental changes in passive stiffness and myofilament Ca2+ sensitivity due to titin and troponin-I isoform switching are not critically triggered by birth
  Krüger M, Kohl T, Linke WA , Am J Physiol Heart Circ Physiol (2006) , 291(2) : H496-506 (Erratum in: Am J Physiol Heart Circ Physiol (2007) 292(1):H726)
• Myocardial structure and function differ in systolic and diastolic heart failure
  van Heerebeek L, Borbély A, Niessen HW, Bronzwaer JG, van der Velden J, Stienen GJ, Linke WA, Laarman GJ, Paulus WJ , Circulation (2006) , 113(16) : 1966-73
• The molecular elasticity of the insect flight muscle proteins projectin and kettin
  Bullard B, Garcia T, Benes V, Leake MC, Linke WA, Oberhauser AF , Proc Natl Acad Sci U S A (2006) , 103(12) : 4451-6

• Plasticity of cardiac titin/connectin in heart development
  Opitz CA, Linke WA , J Muscle Res Cell Motil (2005) , 26(6-8) : 333-42
• Isoform diversity of giant proteins in relation to passive and active contractile properties of rabbit skeletal muscles
  Prado LG, Makarenko I, Andresen C, Krüger M, Opitz CA, Linke WA , J Gen Physiol (2005) , 126(5) : 461-80

• Multiple sources of passive stress relaxation in muscle fibres
  Linke WA, Leake MC , Phys Med Biol (2004) , 49(16) : 3613-27
• Passive stiffness changes caused by upregulation of compliant titin isoforms in human dilated cardiomyopathy hearts
  Makarenko I, Opitz CA, Leake MC, Neagoe C, Kulke M, Gwathmey JK, del Monte F, Hajjar RJ, Linke WA , Circ Res (2004) , 95(7) : 708-16
• Developmentally regulated switching of titin size alters myofibrillar stiffness in the perinatal heart
  Opitz CA, Leake MC, Makarenko I, Benes V, Linke WA , Circ Res (2004) , 94(7) : 967-75
• A troponin switch that regulates muscle contraction by stretch instead of calcium
  Agianian B, Krzic U, Qiu F, Linke WA, Leonard K, Bullard B , EMBO J (2004) , 23(4) : 772-9
• Association of the chaperone alphaB-crystallin with titin in heart muscle
  Bullard B, Ferguson C, Minajeva A, Leake MC, Gautel M, Labeit D, Ding L, Labeit S, Horwitz J, Leonard KR, Linke WA , J Biol Chem (2004) , 279(9) : 7917-24

• Gigantic variety: expression patterns of titin isoforms in striated muscles and consequences for myofibrillar passive stiffness
  Neagoe C, Opitz CA, Makarenko I, Linke WA , J Muscle Res Cell Motil (2003) , 24(2-3) : 175-89
• Damped elastic recoil of the titin spring in myofibrils of human myocardium
  Opitz CA, Kulke M, Leake MC, Neagoe C, Hinssen H, Hajjar RJ, Linke WA , Proc Natl Acad Sci U S A (2003) , 100(22) : 12688-93
• Alcohol affects the skeletal muscle proteins, titin and nebulin in male and female rats
  Hunter RJ, Neagoe C, Järveläinen HA, Martin CR, Lindros KO, Linke WA, Preedy VR , J Nutr (2003) , 133(4) : 1154-7
• Titin stiffness in heart disease
  Linke WA , Circulation (2003) , 107(11) : e73
• Cardiac titin: Molecular basis of elasticity and cellular contribution to elastic and viscous stiffness components in myocardium
  Linke WA, Fernandez JM , In Mechanics of Elastic Biomolecules (Linke, W.A., H. Granzier & M. Kellermayer, Hrg.) Kluwer: Dordrecht (2003) : 483-497
• Varieties of elastic protein in invertebrate muscles
  Bullard B, Linke WA, Leonard K , In Mechanics of Elastic Biomolecules (Linke, W.A., H. Granzier & M. Kellermayer, Hrg.) Kluwer: Dordrecht (2003) : 435-447

• Cardiac titin: molecular basis of elasticity and cellular contribution to elastic and viscous stiffness components in myocardium
  Linke WA, Fernandez JM , J Muscle Res Cell Motil (2002) , 23(5-6) : 483-97
• Varieties of elastic protein in invertebrate muscles
  Bullard B, Linke WA, Leonard K , J Muscle Res Cell Motil (2002) , 23(5-6) : 435-47 (Review)
• Passive stiffness changes in soleus muscles from desmin knockout mice are not due to titin modifications
  Anderson J, Joumaa V, Stevens L, Neagoe C, Li Z, Mounier Y, Linke WA, Goubel F , Pflugers Arch (2002) , 444(6) : 771-6
• Titin isoform switch in ischemic human heart disease
  Neagoe C, Kulke M, del Monte F, Gwathmey JK, de Tombe PP, Hajjar RJ, Linke WA , Circulation (2002) , 106(11) : 1333-41
• Reverse engineering of the giant muscle protein titin
  Li H, Linke WA, Oberhauser AF, Carrion-Vazquez M, Kerkvliet JG, Lu H, Marszalek PE, Fernandez JM , Nature (2002) , 418(6901) : 998-1002
• PEVK domain of titin: an entropic spring with actin-binding properties
  Linke WA, Kulke M, Li H, Fujita-Becker S, Neagoe C, Manstein DJ, Gautel M, Fernandez JM , J Struct Biol (2002) , 137(1-2) : 194-205
• Titin-based contribution to shortening velocity of rabbit skeletal myofibrils
  Minajeva A, Neagoe C, Kulke M, Linke WA , J Physiol (2002) , 540(Pt 1) : 177-88

• Interaction between PEVK-titin and actin filaments: origin of a viscous force component in cardiac myofibrils
  Kulke M, Fujita-Becker S, Rostkova E, Neagoe C, Labeit D, Manstein DJ, Gautel M, Linke WA , Circ Res (2001) , 89(10) : 874-81
• Differentiation- and stress-dependent nuclear cytoplasmic redistribution of myopodin, a novel actin-bundling protein
  Weins A, Schwarz K, Faul C, Barisoni L, Linke WA, Mundel P , J Cell Biol (2001) , 155(3) : 393-404
• Kettin, a major source of myofibrillar stiffness in Drosophila indirect flight muscle
  Kulke M, Neagoe C, Kolmerer B, Minajeva A, Hinssen H, Bullard B, Linke WA , J Cell Biol (2001) , 154(5) : 1045-57
• Unfolding of titin domains explains the viscoelastic behavior of skeletal myofibrils
  Minajeva A, Kulke M, Fernandez JM, Linke WA , Biophys J (2001) , 80(3) : 1442-51
• Hypercontractile properties of cardiac muscle fibers in a knock-in mouse model of cardiac myosin-binding protein-C
  Witt CC, Gerull B, Davies MJ, Centner T, Linke WA, Thierfelder L , J Biol Chem (2001) , 276(7) : 5353-9

• Titin elasticity in the context of the sarcomere: force and extensibility measurements on single myofibrils
  Linke WA , Adv Exp Med Biol (2000) , 481 : 179-206 (Review)
• Stretching molecular springs: elasticity of titin filaments in vertebrate striated muscle
  Linke WA , Histol Histopathol (2000) , 15(3) : 799-811 (Review)
• Sarcomere length-tension relationship of rat cardiac myocytes at lengths greater than optimum
  Weiwad WK, Linke WA, Wussling MH , J Mol Cell Cardiol (2000) , 32(2) : 247-59

• I-band titin in cardiac muscle is a three-element molecular spring and is critical for maintaining thin filament structure
  Linke WA, Rudy DE, Centner T, Gautel M, Witt C, Labeit S, Gregorio CC , J Cell Biol (1999) , 146(3) : 631-44
• The titin cDNA sequence and partial genomic sequences: insights into the molecular genetics, cell biology and physiology of the titin filament system
  Kolmerer B, Witt CC, Freiburg A, Millevoi S, Stier G, Sorimachi H, Pelin K, Carrier L, Schwartz K, Labeit D, Gregorio CC, Linke WA, Labeit S , Rev Physiol Biochem Pharmacol (1999) , 138 : 19-55 (Review)
• Mechanically driven contour-length adjustment in rat cardiac titin's unique N2B sequence: titin is an adjustable spring
  Helmes M, Trombitás K, Centner T, Kellermayer M, Labeit S, Linke WA, Granzier H , Circ Res (1999) , 84(11) : 1339-52

• A spring tale: new facts on titin elasticity
  Linke WA, Granzier H , Biophys J (1998) , 75(6) : 2613-4
• Nature of PEVK-titin elasticity in skeletal muscle
  Linke WA, Ivemeyer M, Mundel P, Stockmeier MR, Kolmerer B , Proc Natl Acad Sci U S A (1998) , 95(14) : 8052-7
• Characterizing titin's I-band Ig domain region as an entropic spring
  Linke WA, Stockmeier MR, Ivemeyer M, Hosser H, Mundel P , J Cell Sci (1998) , 111 : 1567-74
• Striational autoantibodies in myasthenia gravis patients recognize I-band titin epitopes
  Lübke E, Freiburg A, Skeie GO, Kolmerer B, Labeit S, Aarli JA, Gilhus NE, Wollmann R, Wussling M, Rüegg JC, Linke WA , J Neuroimmunol (1998) , 81(1-2) : 98-108
• Auf den Spuren molekularer Federn. Genetische und mechanische Analyse des Muskelproteins Titin
  Linke WA, Labeit S, Rüegg JC , Physiologie. Deutsche Physiologische Gesellschaft (P. Scheid., Ed.) (1998) , 10 : 13-17

• Actin-titin interaction in cardiac myofibrils: probing a physiological role
  Linke WA, Ivemeyer M, Labeit S, Hinssen H, Rüegg JC, Gautel M , Biophys J (1997) , 73(2) : 905-19
• Tissue-specific expression and alpha-actinin binding properties of the Z-disc titin: implications for the nature of vertebrate Z-discs
  Sorimachi H, Freiburg A, Kolmerer B, Ishiura S, Stier G, Gregorio CC, Labeit D, Linke WA, Suzuki K, Labeit S , J Mol Biol (1997) , 270(5) : 688-95
• Basis of passive tension and stiffness in isolated rabbit myofibrils
  Bartoo ML, Linke WA, Pollack GH , Am J Physiol (1997) , 273(1 Pt 1) : C266-76
• The giant protein titin. Emerging roles in physiology and pathophysiology
  Labeit S, Kolmerer B, Linke WA , Circ Res (1997) , 80(2) : 290-4 (Review)

• Towards a molecular understanding of the elasticity of titin
  Linke WA, Ivemeyer M, Olivieri N, Kolmerer B, Rüegg JC, Labeit S , J Mol Biol (1996) , 261(1) : 62-71
• Limits of titin extension in single cardiac myofibrils
  Linke WA, Bartoo ML, Ivemeyer M, Pollack GH , J Muscle Res Cell Motil (1996) , 17(4) : 425-38

• Passive and active tension in single cardiac myofibrils
  Linke WA, Popov VI, Pollack GH , Biophys J (1994) , 67(2) : 782-92

• Spontaneous sarcomeric oscillations at intermediate activation levels in single isolated cardiac myofibrils
  Linke WA, Bartoo ML, Pollack GH , Circ Res (1993) , 73(4) : 724-34

12.10.2017: Posterpreis für Melissa Herwig

01.06.2017: The challenge of treating a stiff heart

30.03.2017: Seltene Muskelkrankheit entdeckt

09.02.2016: Protein Titin hilft, ein paar Kilogramm mehr zu stemmen

21.11.2015: Forschungspreis der Deutschen Duchenne Stiftung

28.08.2015: Herzerkrankung besser verstehen

27.04.2015: Stromausfall: Schaden für die Forschung noch nicht abzusehen

10.10.2014: Interview mit Prof. Linke im ORF 1

ORF1 Ankündigung.pdf   (51.9 kB)

ORF1_Beitrag.mp3 (ca. 7 min)   (4.1 MB)

29.09.2014: Weltherztag

19.03.2014: Wie Herzmuskelzellen ihre Elastizität regulieren

03.02.2014: Prof. Linke im Interview bei J Cell Biol

12.04.2013: Franz-Maximilian-Groedel-Forschungspreis 2013

15.03.2013: Molekularer Ansatz der diastolischen Herzinsuffizienz

14.01.2013: Das hält das Herz elastisch

21.11.2012: Titin - Bandwurmwort füllt dreieinhalbstündiges Video

18.01.2012 : Wie Proteinnetzwerke Muskelfasern stabilisieren

21.12.2011 : Viagra gegen Herzinsuffizienz

14.12.2010 : EU-Förderung (FP7) für MEDIA

Dez. 2004: Titan Titin - Herzmuskelforschung in Münster