The Section of Rheumatology and Clinical Immunology (SRKI, www.ukm.de/index.php) of the Medical Clinic D is closely linked with the Department of Translational Rheumatology and Immunology at the IMM. Both are headed by Prof. Kriegel, which facilitates bench-to-bedside as well as reverse translation in this research area. In addition to specialized clinical care for rheumatologic patients, the SRKI is also developing translational studies that examine the microbiome in autoimmune diseases in more detail. Stool, skin and oral cavity samples, among other, are collected in order to mechanistically study the microbiota in these clinical settings in the Department of Translational Rheumatology.
The Department of Translational Rheumatology and Immunology researches the development of rheumatic and other immune-mediated diseases with a focus on the role of the microbiome. In particular, we investigate the interaction between the immune system and commensal bacteria on the skin, the intestines and other mucosal sites such as the oral cavity. We have previously discovered (at Yale University, medicine.yale.edu/lab/kriegel/) so called pathobionts that trigger or worsen autoimmunity through various cellular and molecular mechanisms. In addition, we have developed strategies in experimental models to modulate the microbiome in order to reduce the severity or prevent the development of these diseases. These interventions relate to vaccinations against commensal bacteria, dietary changes, and antibiotics. You can find more details about our research, the location of our research laboratory and detailed projects here: www.medizin.uni-muenster.de/mikrobiom/startseite/
A) The role of intestinal wall permeability and translocating pathobionts in autoimmune diseases
B) The influence of diet and the environment on the microbiome and microbiome-associated diseases
C) Disruption of immunological tolerance by microbiota
D) The role of the microbiome in the development of tumors of lymphatic tissue.
- Vieira SM, Hiltensperger M, Kumar V, Zegarra-Ruiz D, Dehner C, Kahn N, Costa FRC, Tiniakou E, Greiling T, Ruff W, Barbieri A, Kriegel C, Mehta SS, Knight JR, Jain D, Goodman AL, Kriegel MA. Translocation of a Gut Pathobiont Drives Autoimmunity in Mice and Humans. Science, 2018; 359:1156-1161.
- Greiling TM*, Dehner C*, Chen X*, Hughes K, Renfroe SC, Vieira SM, Ruff WE, Boccitto M, Sim S, Kriegel C, Chen X, Girardi M, Degnan P, Goodman AL, Wolin SL#, Kriegel MA#. Commensal Orthologs of the Human Autoantigen Ro60 as Triggers of Autoimmunity in Lupus. Science Translational Medicine, 2018; eaan2306. (#co-correspondence).
- Zegarra-Ruiz D, El Beidaq A, Iniguez, AJ, Lubrano Di Ricco M, Manfredo Vieira S, Ruff WE, Mubiru D, Sterpka J, Greiling TM, Dehner C, Kriegel MA. A diet-sensitive commensal Lactobacillus strain mediates TLR7-dependent systemic autoimmunity. Cell Host Microbe, 2019; 25(1):113-127.
- Ruff WE, Dehner C, Kim WJ, Pagovich O, Aguiar CL, Yu AT, Roth AS, Manfredo Vieira, S, Kriegel S, Olamide A, Mulla MJ, Abrahams VM, Kwok WW, Nussinov R, Erkan D, Goodman AL, Kriegel MA. Pathogenic beta2-glycoprotein I autoreactive T and B cells cross-react with non-orthologous mimotopes expressed by a common human gut commensal. Cell Host Microbe, 2019; 26: 100-113.
- Ruff WE, Greiling TM, Kriegel MA. Host-microbiota interactions in immune-mediated diseases. Nature Reviews Microbiology 2020; Sep;18(9):521-538. PMID: 32457482.