Section of Rheumatology and Clinical Immunology

The Section of Rheumatology and Clinical Immunology (SRKI, www.ukm.de/index.php) of the Medical Clinic D is closely linked with the Department of Translational Rheumatology and Immunology at the IMM. Both are headed by Prof. Kriegel, which facilitates bench-to-bedside as well as reverse translation in this research area. In addition to specialized clinical care for rheumatologic patients, the SRKI is also developing translational studies that examine the microbiome in autoimmune diseases in more detail. Stool, skin and oral cavity samples, among other, are collected in order to mechanistically study the microbiota in these clinical settings in the Department of Translational Rheumatology.

Department of Translational Rheumatology and Immunology

The Department of Translational Rheumatology and Immunology researches the development of rheumatic and other immune-mediated diseases with a focus on the role of the microbiome. In particular, we investigate the interaction between the immune system and commensal bacteria on the skin, the intestines and other mucosal sites such as the oral cavity. We have previously discovered (at Yale University, medicine.yale.edu/lab/kriegel/) so called pathobionts that trigger or worsen autoimmunity through various cellular and molecular mechanisms. In addition, we have developed strategies in experimental models to modulate the microbiome in order to reduce the severity or prevent the development of these diseases. These interventions relate to vaccinations against commensal bacteria, dietary changes, and antibiotics. You can find more details about our research, the location of our research laboratory and detailed projects here: www.medizin.uni-muenster.de/mikrobiom/startseite/