Modern next-generation sequencing techniques allow, in addition to providing insights into the average gene expression of cell samples, the analysis of the transcriptome of individual cells (single-cell RNA-seq or scRNA-seq) and the investigation of expression in the spatial tissue context (spatial transcriptomics). These highly specialized techniques can be used to explore disease mechanisms at various levels and potentially identify new treatment approaches.
In collaboration with the Department of Neurology (Prof. Klotz), we use not only RNA-seq and scRNA-seq, but also current spatial transcriptomics techniques to characterize inflammatory processes in neurological diseases such as multiple sclerosis, or to analyze processes involved in immunosenescence, a premature aging of the immune system.
 

Contact: Dr. Carolin Walter