Jens Hausmann
Ph.D.

Wissenschaftlicher Mitarbeiter
Institut für Anatomie & Molekulare Neurobiologie

Vesaliusweg 2-4, 48149 Münster

Telefon: +49 (0) 251 83-55246
Telefax: +49 (0) 251 83-50248
Email: Jens Hausmann

  • Lebenslauf

  • Publikationen


    Originalarbeiten (nur „peer-reviewed“):

    1. Cremers C.M., Reichmann D., Hausmann J., Ilbert M. and Jakob U. (2010); Unfolding of metastable linker region is at the core of Hsp33 activation as a redox-regulated chaperone; J. Biol. Chem. 285(15):11243-11251
    2. Day J.E., Hall T, Pegg L.E., Benson T.E., Hausmann J. and Kamtekar S. (2010); Crystallization and preliminary X-ray diffraction analysis of rat autotaxin; Acta Crystallogr. F 66(Pt 9):1127-1129
    3. Hausmann J., Christodoulou E., Kasiem M., De Marco V., van Meeteren L.A., Moolenaar W.H., Axford D., Owen R.L., Evans G., and Perrakis A. (2010); Mammalian cell expression, purification, crystallization and microcrystal data collection of autotaxin/ENPP2, a secreted mammalian glycoprotein; Acta Crystallogr. F 66(Pt 9):1130-1135
    4. Karagoz G.E., Duarte A.M., Ippel H., Uetrecht C., Sinnige T., van Rosmalen M., Hausmann J., Heck A.J., Boelens R., and Rudiger S.G. (2011); N-terminal domain of human Hsp90 triggers binding to the cochaperone p23; PNAS 108(2):580-585
    5. Hausmann J., Kamtekar S., Christodoulou E., Day J.E., Wu T., Fulkerson Z., Albers H.M.H.G., van Meeteren L.A., Houben A.J., van Zeijl L., Jansen S., Andries M., Hall T., Pegg L.E., Benson T.E., Kasiem M., Harlos K., Kooi C.W., Smyth S.S., Ovaa H., Bollen M., Morris A.J., Moolenaar W.H. and Perrakis A.; (2011) Structural basis of substrate discrimination and integrin binding by autotaxin; Nat. Struct. Mol. Biol. 18:198-204
    6. Albers H.M.H.G., Hendrickx L.J., van Tol R.J., Hausmann J., Perrakis A., and Ovaa H. (2011); Structure-based design of novel boronic acid-based inhibitors of autotaxin; J. Med. Chem. 54(13):4619-4626
    7. Kryshtafovych A., Moult J., Bartual S.G., Bazan J.F., Berman H., Casteel D.E., Christodoulou E., Everett J.K., Hausmann J., Heidebrecht T., Hills T., Hui R., Hunt J.F., Seetharaman J., Joachimiak A., Kennedy M.A., Kim C., Lingel A., Michalska K., Montelione G.T., Otero J.M., Perrakis A., Pizarro J.C., van Raaij M.J., Ramelot T.A., Rousseau F., Tong L., Wernimont A.K., Young J. and Schwede T. (2011); Target highlights in CASP9: Experimental target structures for the critical assessment of techniques for protein structure prediction; Proteins 79(10):6-20
    8. Houben A.J., van Wijk X.M., van Meeteren L.A., van Zeijl L., van de Westerlo E.M., Hausmann J., Fish A., Perrakis A., van Kuppevelt T.H. and Moolenaar W.H. (2013); The Polybasic Insertion in Autotaxin alpha Confers Specific Binding to Heparin and Cell Surface Heparan Sulfate Proteoglycans; J. Biol. Chem. 288(1):510-519
    9. Keune W.J., Hausmann J., Bolier R., Tolenaars D., Kremer A., Heidebrecht T., Joosten R., Sunkara M., Morris A.J., Matas-Rico E., Moolenaar W.H., Oude Elferink R., Perrakis A. (2016); Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signaling; Nat. Commun. 7:11248
    10. Hausmann J., Joosten R., van Zeijl L., Hipgrave Ederveen A.L., Moolenaar W.H., Perrakis A. (2016); Structural Snapshots of Autotaxin/ENPP2 and their implications for the catalysis; J. Struct. Biol. 195(2):199-206
    11. Brandt N., Willmer J.P., Ayon-Olivas M.S., Banicka V., Witt M., Wree A., Groß I., Gläser A., Hausmann J., Bräuer A.U. (2022); PRG3 and PRG5 C-Termini: Important Players in Early Neuronal Differentiation; Int. J. Mol. Sci. 23(21):13007
    12. Eymery M.C., McCarthy A.A., Hausmann J. (2023); Linking medicinal cannabis to autotaxinlysophosphatidic acid signaling; Life Sci. Alliance 6(2):e202201595
    13. Becker L., Hausmann J., Hartmann A.M. (2023); Both chloride binding sites are required for KCC2 mediated-transport; J. Biol. Chem. 299(10):105190
    14. Eymery M.C., Nguyen K., Basu S., Hausmann J., Nguyen V.T., Seidel H.S., Gutierrez L., Boumendjel A., McCarthy A.A. (2023); Discovery of potent chromone-based autotaxin inhibitors inspired by cannabinoids; Eur. J. Med. Chem. 263:115944
    15. Becker L., Hausmann J., Wellpott R., Hartmann A.M. (2025); Highly conserved ion binding sites are not all functionally relevant in mouse KCC4; Front. Mol. Biosci. 12:1556250
    16. Chen Y., Hausmann J., Zimmermann B., Helgers S.O.A., Dömer P., Woitzik J., Raap U., Gray N., Büttner A., Koch K.W., Bräuer A.U. (2025); Retinal degeneration protein 3 mutants are associated with cell-cycle arrest and apoptosis; Cell Death Discov. 11 (1):175
    17. Hamze M., Whitney R., Ville D., Villeneuve N., Hartmann A.M., Becker L., Hausmann J., Zhang J., Brier C., Pisella L.I., Friedel P., Labalme A., Alix E., Chatron N., Sanlaville D., Gory-Faur S., Denarier E., Porcher C., Lesca G., Medina I. (2026); Compound heterozygous SLC12A5 variants expand the molecular and functional spectrum of KCC2-developmental and epileptic encephalopathy; Epilepsia 67(7):3657-3673 Online ahead of print

    Übersichtsarbeiten („peer-reviewed“):

    1. Hausmann J., Perrakis A. and Moolenaar W.H. (2013); Structure-function relationships of autotaxin, a secreted lysophospholipase D; Adv. Biol. Regul. 53(1):112–117
    2. Eymery M.C., Boumendjel A., McCarthy A.A., Hausmann J. (2024); Linking the Autotaxin-LPA Axis to Medicinal Cannabis and the Endocannabinoid System; Int. J. Mol. Sci. 25(6):3212
    3. Brandt N., Köper F., Hausmann J., Bräuer A.U. (2025); Spotlight on plasticity-related genes: Current insights in health and disease; Pharmacol. Ther. 260:108687

  • Stipendien & Auszeichnungen