Dr. rer. nat. Samuel Young

Regenerative Biomedicine
Centre of Reproductive Medicine and Andrology
Albert-Schweitzer-Campus 1, Geb. D11
48149 Münster
Tel. +49 (0)251 83-54858
E-Mail: Samuel Young
Research Gate

  • Scientific career

    since 2021 Scientist at the Centre for Reproductive Medicine and Andrology of the University Hospital Münster
    2021 Ph.D. degree in Biology, University of Münster
    2017-2021 Ph.D. thesis at the Centre for Reproductive Medicine and Andrology of the University Hospital Münster
    2013-2017 Master's degree in Biomedical Engineering, Münster University of Applied Sciences
    2008-2010 Research Associate II, Synthetic Genomics Inc. (La Jolla, California, USA)
    2002-2008 Bachelor's degree in Chemical Engineering, Oregon State University (Corvallis, Oregon, USA)
  • Publications

    Young, S.*, Schiffer, C.*, Wagner, A., Patz, J., Potapenko, A., Herrmann, L., Nordhoff, V., Pock, T., Krallmann, C., Stallmeyer, B., Röpke, A., Kierzek, M., Biagioni, C., Wang, T., Haalck, L., Deuster, D., Hansen, J. N., Wachten, D., Risse, B., Behre, H. M., Schlatt, S., Kliesch, S., Tüttelmann, F., Brenker, C., Strünker, T. (2023) "Unexplained infertility is frequently caused by defective CatSper function preventing sperm from penetrating the egg coat" MedRxiv 2023.03.23.23286813, doi.org/10.1101/2023.03.23.23286813
    Schneider, S., Kovacevic, A., Mayer, M, Dicke, A. K., Arévalo, L., Koser, S. A., Hansen, J. N., Young, S., Brenker, C., Kliesch, S., Wachten, D., Kirfel, G., Strünker, T., Tüttelmann, F., Schorle, H., (2023) "Cylicins are a structural component of the sperm calyx being indispensable for male fertility in mice and human" Elife; reviewed preprint doi.org/10.7554/eLife.86100.1
    Dougherty GW, Mizuno K, Nöthe-Menchen T, Ikawa Y, Boldt K, Ta-Shma A, Aprea I, Minegishi K, Pang YP, Pennekamp P, Loges NT, Raidt J, Hjeij R, Wallmeier J, Mussaffi H, Perles Z, Elpeleg O, Rabert F, Shiratori H, Letteboer SJ, Horn N, Young S, Strünker T, Stumme F, Werner C, Olbrich H, Takaoka K, Ide T, Twan WK, Biebach L, Große-Onnebrink J, Klinkenbusch JA, Praveen K, Bracht DC, Höben IM, Junger K, Gützlaff J, Cindrić S, Aviram M, Kaiser T, Memari Y, Dzeja PP, Dworniczak B, Ueffing M, Roepman R, Bartscherer K, Katsanis N, Davis EE, Amirav I, Hamada H, Omran H. (2020) "CFAP45 deficiency causes situs abnormalities and asthenospermia by disrupting an axonemal adenine nucleotide homeostasis module." Nature Communications. 2020 Nov 2;11(1):5520. doi.org/10.1038/s41467-020-19113-0.
    Schiffer, C., Brenker, C., Strünker, T., Young, S. (2020) "CatSper-Activity-Test for determining male infertility." European Patent Application: PCT/EP2020/057904. patentscope.wipo.int/search/en/detail.jsf
    Wang, T., Young, S., Krenz, H., Tüttelmann, F., Röpke, A., Krallmann, C., Kliesch, S., Zeng, X., Brenker, C., & Strünker, T. (2020) "The Ca2+ channel CatSper is not activated by cAMP/PKA signaling but directly affected by chemicals used to probe the action of cAMP and PKA." Journal of Biological Chemistry. doi.org/10.1074/jbc.RA120.013218
    Schiffer C, Rieger S, Brenker C, Young S, Hamzeh H, Wachten D, Tüttelmann F, Röpke A, Kaupp UB, Wang T, Wagner A, Krallmann C, Kliesch S, Fallnich C, Strünker T. (2020) "Rotational motion and rheotaxis of human sperm do not require functional CatSper channels and transmembrane Ca2+ signaling." EMBO J. (2020) Jan 39:e102363. doi.org/10.15252/embj.2019102363.
    *contributed equally