Abdelwhab EM, Veits J, Tauscher K, Ziller M, Teifke JP, Stech J, Mettenleiter TC. A Unique Multibasic Proteolytic Cleavage Site and Three Mutations in the HA2 Domain Confer High Virulence of H7N1 Avian Influenza Virus in Chickens. J Virol. 2015 Oct 21. pii: JVI.02082-15. [Epub ahead of print]Arafa AS, Naguib MM, Luttermann C, Selim AA, Kilany WH, Hagag N, Samy A, Abdelhalim A, Hassan MK, Abdelwhab EM, Makonnen Y, Dauphin G, Lubroth J, Mettenleiter TC, Beer M, Grund C, Harder TC. Emergence of a novel cluster of influenza A(H5N1) virus clade 2.2.1.2 with putative human health impact in Egypt, 2014/15.
Euro Surveill. 2015 Apr 2;20(13):2-8.Börgeling Y, Rozhdestvensky TS, Schmolke M, Resa-Infante P, Robeck T, Randau G, Wolff T, Gabriel G, Brosius J, and Ludwig S (2015) Evidence for a Novel Mechanism of Influenza Virus-Induced Type I Interferon Expression by a Defective RNA-Encoded Protein. PLoS Pathogens. 11:e1004924Conraths FJ, Sauter-Louis C, Globig A, Dietze K, Pannwitz G, Albrecht K, Höreth-Böntgen D, Beer M, Staubach C, Homeier-Bachmann T. Highly Pathogenic Avian Influenza H5N8 in Germany: Outbreak Investigations. Transbound Emerg Dis. 2015 Oct 30. doi: 10.1111/tbed.12443. [Epub ahead of print]Gambaryan AS, Matrosovich M. 2015. What adaptive changes in hemagglutinin and neuraminidase are necessary for emergence of pandemic influenza virus from its avian precursor? Biochemistry (Moscow) 80:872-880.Gnirß K, Zmora P, Blazejewska P, Winkler M, Lins A, Nehlmeier I, Gärtner S, Moldenhauer AS, Hofmann-Winkler H, Wolff T, Schindler M, Pöhlmann S.
Tetherin Sensitivity of Influenza A Viruses Is Strain Specific: Role of Hemagglutinin and Neuraminidase. J Virol. 2015 Sep;89(18):9178-88. doi: 10.1128/JVI.00615-15. Epub 2015 Jun 24.Harder T, Maurer-Stroh S, Pohlmann A, Starick E, Höreth-Böntgen D, Albrecht K, Pannwitz G, Teifke J, Gunalan V, Lee RT, Sauter-Louis C, Homeier T, Staubach C, Wolf C, Strebelow G, Höper D, Grund C, Conraths FJ, Mettenleiter TC, BeerM.
Influenza A(H5N8) Virus Similar to Strain in Korea Causing Highly Pathogenic Avian Influenza in Germany.
Emerg Infect Dis. 2015 May;21(5):860-3. doi: 10.3201/eid2105.141897.Heider A, Mochalova L, Harder T, Tuzikov A, Bovin N, Wolff T, Matrosovich M, Schweiger B. 2015. Alterations in hemagglutinin receptor-binding specificity accompany the emergence of highly pathogenic avian influenza viruses. J Virol 89:5395-5405.Herold S, Becker C, Ridge KM, Budinger GR.
Influenza virus-induced lung injury: pathogenesis and implications for treatment.
Eur Respir J. 2015 May;45(5):1463-78. doi: 10.1183/09031936.00186214. Epub 2015 Mar 18.Herrmann VL, Hartmayer C, Planz O, Groettrup M.
Cytotoxic T cell vaccination with PLGA microspheres interferes with influenza A virus replication in the lung and suppresses the infectious disease.
J Control Release. 2015 Oct 28;216:121-31. doi: 10.1016/j.jconrel.2015.08.019. Epub 2015 Aug 12.Hoffmann D, Röhrs S, Rahn J, Stech J, Beer M. Pathogenicity evaluation of neuraminidase-negative H5 and H7 viruses in day-old chicks and adult chicken. Vaccine. 2015 Oct 21. pii: S0264-410X(15)01408-5. doi: 10.1016/j.vaccine.2015.09.106. [Epub ahead of print]Hrincius ER, Liedmann S, Finkelstein D, Vogel P, Gansebom S, Ehrhardt C, Ludwig S, Hains DS, Webby R, and McCullers JA. (2015) NS1 mediated inhibition of c-Abl results in acute lung injury and priming for bacterial co-infections; insights into 1918 H1N1 pandemic?Journal of Infectious Diseases. 211, 1418-1428Kathum OA, Schräder T, Anhlan, D, Nordhoff C, Liedmann S, Pande A, Mellmann A, Ehrhardt C, Wixler, V and Ludwig S (2015) Phosphorylation of Influenza A virus NS1 protein at threonine 49 suppresses its interferon antagonistic activity. Cellular Microbiology, in pressLê, V.B., Schneider, J.G., Börgeling, Y., Berri, F., Ducatez, M., Guerin, J.-L., Adrian, I., Errazuriz-Cerda, E., Frasquilho, S., Antunes, L., Lina, B., Bordet, J.-C., Jandrot-Perrus, M., Ludwig S., and Riteau, B. (2015) Platelet activation and aggregation promote lung inflammation and influenza virus 1 pathogenesis. American Journal of Respiratory and Critical Care Medicine, 191, 804-819Meng F, Wu NH, Nerlich A, Herrler G, Valentin-Weigand P, Seitz M. Dynamic virus-bacterium interactions in a porcine precision-cut lung slice coinfection model: Swine influenza virus paves the way for Streptococcus suis infection in a two-step process. Infect Immun. 2015; 83:2806-2815.Mostafa A, Kanrai P, Petersen H, Ibrahim S, Rautenschlein S, Pleschka S. Efficient generation of recombinant influenza A viruses employing a new approach to overcome the genetic instability of HA segments. PLoS One. 2015 Jan 23;10(1):e0116917. doi: 10.1371/journal.pone.0116917. eCollection 2015.Mühlbauer D, Dzieciolowski J, Hardt M, Hocke A, Schierhorn KL, Mostafa A, Müller C, Wisskirchen C, Herold S, Wolff T, Ziebuhr J, Pleschka S. Influenza virus-induced caspase-dependent enlargement of nuclear pores promotes nuclear export of viral ribonucleoprotein complexes. J Virol. 2015 Jun;89(11):6009-21. doi: 10.1128/JVI.03531-14. Epub 2015 Mar 25.Naguib MM, Kinne J, Chen H, Chan KH, Joseph S, Wong PC, Woo PC, Wernery R, Beer M, Wernery U, Harder TC.
Outbreaks of highly pathogenic avian influenza H5N1 clade 2.3.2.1c in hunting falcons and kept wild birds in Dubai implicate intercontinental virus spread.
J Gen Virol. 2015 Sep 7. doi: 10.1099/jgv.0.000274. [Epub ahead of print]Naguib MM, Arafa AS, El-Kady MF, Selim AA, Gunalan V, Maurer-Stroh S, Goller KV, Hassan MK, Beer M, Abdelwhab EM, Harder TC.
Evolutionary trajectories and diagnostic challenges of potentially zoonotic avian influenza viruses H5N1 and H9N2 co-circulating in Egypt.
Infect Genet Evol. 2015 Aug;34:278-91. doi: 10.1016/j.meegid.2015.06.004. Epub 2015 Jun 3.Patil HP, Murugappan S, de Vries-Idema J, Meijerhof T, de Haan A, Frijlink HW, Wilschut J, Hinrichs WL, Huckriede A. Comparison of adjuvants for a spray freeze-dried whole inactivated virus influenza vaccine for pulmonary administration. Eur J Pharm Biopharm. 2015 Jun;93:231-41.Preusse, M., Schughart, K., Wilk, E., Klawonn, F., and Pessler, F. (2015). Hematological parameters in the early phase of influenza A virus infection in differentially susceptible inbred mouse strains. BMC Res Notes 8, 225.
Punyadarsaniya D, Winter C, Mork AK, Amiri M, Naim HY, Rautenschlein S, Herrler G.Precision-cut intestinal slices as a culture system to analyze the infection of differentiated intestinal epithelial cells by avian influenza viruses. J Virol Methods. 2015 Feb;212:71-5. doi: 10.1016/j.jviromet.2014.10.015. Epub 2014 Nov 13.Rahn J, Hoffmann D, Harder TC, Beer M.
Vaccines against influenza A viruses in poultry and swine: Status and future developments.
Vaccine. 2015 May 15;33(21):2414-24. doi: 10.1016/j.vaccine.2015.03.052. Epub 2015 Mar 31. Review.Reiche J, Böttcher S, Diedrich S, Buchholz U, Buda S, Haas W, Schweiger B, WolffT.
Low-level Circulation of Enterovirus D68-Associated Acute Respiratory Infections, Germany, 2014.
Emerg Infect Dis. 2015 May;21(5):837-41. doi: 10.3201/eid2105.141900.Reppe K, Radünzel P, Dietert K, Tschernig T, WolffT, Hammerschmidt S, Gruber AD, Suttorp N, Witzenrath M.
Pulmonary Immunostimulation with MALP-2 in Influenza Virus-Infected Mice Increases Survival after Pneumococcal Superinfection.
Infect Immun. 2015 Dec;83(12):4617-29. doi: 10.1128/IAI.00948-15. Epub 2015 Sep 14.Reuther P, Göpfert K, Dudek AH, Heiner M, Herold S, Schwemmle M.
Generation of a variety of stable Influenza A reporter viruses by genetic engineering of the NS gene segment. Sci Rep. 2015 Jun 12;5:11346. doi: 10.1038/srep11346.Schmier S, Mostafa A, Haarmann T, Bannert N, Ziebuhr J, Veljkovic V, Dietrich U, Pleschka S. In Silico Prediction and Experimental Confirmation of HA Residues Conferring Enhanced Human Receptor Specificity of H5N1 Influenza A Viruses. Sci Rep. 2015 Jun 19;5:11434. doi: 10.1038/srep11434.Silva IT, Carvalho A, Lang KL, Dudek SE, Masemann D, Durán FJ, Caro MSB, Rapp UR, Wixler V, Schenkel EP, Simões CMO, and Ludwig S (2015) In vitro and in vivo antitumor activity of a novel semisynthetic derivative of cucurbitacin B https://www.ncbi.nlm.nih.gov/pubmed/?term=In+vitro+and+in+vivo+antitumor+activity+of+a+novel+semisynthetic+derivative+of+cucurbitacin+BPLoS ONE,10:e0117794Stech O, Veits J, Abdelwhab el-SM, Wessels U, Mettenleiter TC, Stech J.
The Neuraminidase Stalk Deletion Serves as Major Virulence Determinant of H5N1 Highly Pathogenic Avian Influenza Viruses in Chicken. Sci Rep. 2015 Aug 26;5:13493. doi: 10.1038/srep13493.Shin, D.L., Hatesuer, B., Bergmann, S., Nedelko, T., and Schughart, K. (2015). Protection from Severe Influenza Virus Infections in Mice Carrying the Mx1 Influenza Virus Resistance Gene Strongly Depends on Genetic Background. J Virol 89, 9998-10009.Shpacovitch V, Temchura V, Matrosovich M, Hamacher J, Skolnik J, Libuschewski P, Siedhoff D, Weichert F, Marwedel P, Muller H, Uberla K, Hergenroder R, Zybin A. 2015. https://www.ncbi.nlm.nih.gov/pubmed/?term=Application+of+surface+plasmon+resonance+imaging+technique+for+the+detection+of+single+spherical+biological+submicrometer+particles.Application of surface plasmon resonance imaging technique for the detection of single spherical biological submicrometer particles. Anal Biochem 486:62-69.Sid H, Benachour K, Rautenschlein S. Co-infection with Multiple Respiratory Pathogens Contributes to Increased Mortality Rates in Algerian Poultry Flocks. Avian Dis. 2015 Sep;59(3):440-6.Stoel M, Pool J, de Vries-Idema J, Zaaraoui-Boutahar F, Bijl M, Andeweg AC, Wilschut J, Huckriede A. Innate responses induced by whole inactivated virus or subunit influenza vaccines in cultured dendritic cells correlate with immune responses in vivo. PLoS One. 2015 May 1;10(5):e0125228. van Doorn E, Liu H, Huckriede A, Hak E.
Safety and tolerability evaluation of the use of Montanide ISA™51 as vaccine adjuvant: A systematic review. Hum Vaccin Immunother. 2015 Sep 17:1-11.Van Poucke S, Doedt J, Baumann J, Qiu Y, Matrosovich T, Klenk HD, Van Reeth K, Matrosovich M. 2015.
Role of Substitutions in the Hemagglutinin in the Emergence of the 1968 Pandemic Influenza Virus. J Virol 89:12211-12216.Verhelst,J., Spitaels, J., Nürnberger, C., De Vlieger, D., Ysenbaert, T., Staeheli, P., Fiers, W., & Xavier Saelens. Functional comparison of Mx1 from two different mouse species reveals the involvement of loop L4 in the antiviral activity against influenza A viruses. J. Virol. 89: 10879-10890 (2015)von Recum-Knepper J, Sadewasser A, Weinheimer VK, Wolff T.
Fluorescence-Activated Cell Sorting-Based Analysis Reveals an Asymmetric Induction of Interferon-Stimulated Genes in Response to Seasonal Influenza A Virus.
J Virol. 2015 Jul;89(14):6982-93. doi: 10.1128/JVI.00857-15. Epub 2015 Apr 22.Warnking K, Klemm C, Löffler B, Niemann S, van Krüchten A, Peters G, Ludwig S, and Ehrhardt C (2015). Super-infection with Staphylococcus aureus inhibits influenza virus-induced type I IFN signalling through impaired STAT1-STAT2 dimerization. Cellular Microbiology. 17, 303-317Weber M, Sediri H, Felgenhauer U, Binzen I, Bänfer S, Jacob R, Brunotte L, García-Sastre A, Schmid-Burgk JL, Schmidt T, Hornung V, Kochs G, Schwemmle M, Klenk HD, Weber F.
Influenza virus adaptation PB2-627K modulates nucleocapsid inhibition by the pathogen sensor RIG-I.
Cell Host Microbe. 2015 Mar 11;17(3):309-19. doi: 10.1016/j.chom.2015.01.005. Epub 2015 Feb 19.Wedde M, Biere B, Wolff T, Schweiger B.Evolution of the hemagglutinin expressed by human influenza A(H1N1)pdm09 and A(H3N2) viruses circulating between 2008-2009 and 2013-2014 in Germany. Int J Med Microbiol. 2015 Oct;305(7):762-75. doi: 10.1016/j.ijmm.2015.08.030. Epub 2015 Aug 21. Wendel, I., Rubbenstroth, D., Doedt, J., Kochs, G., Wilhelm, J., Staeheli, P., Klenk, H., & M.Matrosovich. The avian-origin PB1 gene segment facilitated replication and transmissibility of the H3N2/1968 pandemic influenza virus. J. Virol. 89: 4170-4179 (2015)Wendel I, Matrosovich M, Klenk HD. 2015.
SnapShot: Evolution of Human Influenza A Viruses. Cell Host & Microbe 17:416-416.e411.Wessels U, Stech O, Abdelwhab el-SM, Judel A, Mettenleiter TC, Stech J.
Improved universal cloning of influenza A virus genes by LacZα-mediated blue/white selection. J Virol Methods. 2015 Dec 1;225:87-9. doi: 10.1016/j.jviromet.2015.09.009. Epub 2015 Sep 25.Wilk, E., Pandey, A.K., Leist, S.R., Hatesuer, B., Preusse, M., Pommerenke, C., Wang, J., and Schughart, K. (2015). RNAseq expression analysis of resistant and susceptible mice after influenza A virus infection identifies novel genes associated with virus replication and important for host resistance to infection. BMC Genomics 16, 655.Wu NH, Meng F, Seitz M, Valentin-Weigand P, Herrler G.
Sialic acid-dependent interactions between influenza viruses and Streptococcus suis affect the infection of porcine tracheal cells. J Gen Virol. 2015; 96:2557-2568.
Euro Surveill. 2015 Apr 2;20(13):2-8.Börgeling Y, Rozhdestvensky TS, Schmolke M, Resa-Infante P, Robeck T, Randau G, Wolff T, Gabriel G, Brosius J, and Ludwig S (2015) Evidence for a Novel Mechanism of Influenza Virus-Induced Type I Interferon Expression by a Defective RNA-Encoded Protein. PLoS Pathogens. 11:e1004924Conraths FJ, Sauter-Louis C, Globig A, Dietze K, Pannwitz G, Albrecht K, Höreth-Böntgen D, Beer M, Staubach C, Homeier-Bachmann T. Highly Pathogenic Avian Influenza H5N8 in Germany: Outbreak Investigations. Transbound Emerg Dis. 2015 Oct 30. doi: 10.1111/tbed.12443. [Epub ahead of print]Gambaryan AS, Matrosovich M. 2015. What adaptive changes in hemagglutinin and neuraminidase are necessary for emergence of pandemic influenza virus from its avian precursor? Biochemistry (Moscow) 80:872-880.Gnirß K, Zmora P, Blazejewska P, Winkler M, Lins A, Nehlmeier I, Gärtner S, Moldenhauer AS, Hofmann-Winkler H, Wolff T, Schindler M, Pöhlmann S.
Tetherin Sensitivity of Influenza A Viruses Is Strain Specific: Role of Hemagglutinin and Neuraminidase. J Virol. 2015 Sep;89(18):9178-88. doi: 10.1128/JVI.00615-15. Epub 2015 Jun 24.Harder T, Maurer-Stroh S, Pohlmann A, Starick E, Höreth-Böntgen D, Albrecht K, Pannwitz G, Teifke J, Gunalan V, Lee RT, Sauter-Louis C, Homeier T, Staubach C, Wolf C, Strebelow G, Höper D, Grund C, Conraths FJ, Mettenleiter TC, BeerM.
Influenza A(H5N8) Virus Similar to Strain in Korea Causing Highly Pathogenic Avian Influenza in Germany.
Emerg Infect Dis. 2015 May;21(5):860-3. doi: 10.3201/eid2105.141897.Heider A, Mochalova L, Harder T, Tuzikov A, Bovin N, Wolff T, Matrosovich M, Schweiger B. 2015. Alterations in hemagglutinin receptor-binding specificity accompany the emergence of highly pathogenic avian influenza viruses. J Virol 89:5395-5405.Herold S, Becker C, Ridge KM, Budinger GR.
Influenza virus-induced lung injury: pathogenesis and implications for treatment.
Eur Respir J. 2015 May;45(5):1463-78. doi: 10.1183/09031936.00186214. Epub 2015 Mar 18.Herrmann VL, Hartmayer C, Planz O, Groettrup M.
Cytotoxic T cell vaccination with PLGA microspheres interferes with influenza A virus replication in the lung and suppresses the infectious disease.
J Control Release. 2015 Oct 28;216:121-31. doi: 10.1016/j.jconrel.2015.08.019. Epub 2015 Aug 12.Hoffmann D, Röhrs S, Rahn J, Stech J, Beer M. Pathogenicity evaluation of neuraminidase-negative H5 and H7 viruses in day-old chicks and adult chicken. Vaccine. 2015 Oct 21. pii: S0264-410X(15)01408-5. doi: 10.1016/j.vaccine.2015.09.106. [Epub ahead of print]Hrincius ER, Liedmann S, Finkelstein D, Vogel P, Gansebom S, Ehrhardt C, Ludwig S, Hains DS, Webby R, and McCullers JA. (2015) NS1 mediated inhibition of c-Abl results in acute lung injury and priming for bacterial co-infections; insights into 1918 H1N1 pandemic?Journal of Infectious Diseases. 211, 1418-1428Kathum OA, Schräder T, Anhlan, D, Nordhoff C, Liedmann S, Pande A, Mellmann A, Ehrhardt C, Wixler, V and Ludwig S (2015) Phosphorylation of Influenza A virus NS1 protein at threonine 49 suppresses its interferon antagonistic activity. Cellular Microbiology, in pressLê, V.B., Schneider, J.G., Börgeling, Y., Berri, F., Ducatez, M., Guerin, J.-L., Adrian, I., Errazuriz-Cerda, E., Frasquilho, S., Antunes, L., Lina, B., Bordet, J.-C., Jandrot-Perrus, M., Ludwig S., and Riteau, B. (2015) Platelet activation and aggregation promote lung inflammation and influenza virus 1 pathogenesis. American Journal of Respiratory and Critical Care Medicine, 191, 804-819Meng F, Wu NH, Nerlich A, Herrler G, Valentin-Weigand P, Seitz M. Dynamic virus-bacterium interactions in a porcine precision-cut lung slice coinfection model: Swine influenza virus paves the way for Streptococcus suis infection in a two-step process. Infect Immun. 2015; 83:2806-2815.Mostafa A, Kanrai P, Petersen H, Ibrahim S, Rautenschlein S, Pleschka S. Efficient generation of recombinant influenza A viruses employing a new approach to overcome the genetic instability of HA segments. PLoS One. 2015 Jan 23;10(1):e0116917. doi: 10.1371/journal.pone.0116917. eCollection 2015.Mühlbauer D, Dzieciolowski J, Hardt M, Hocke A, Schierhorn KL, Mostafa A, Müller C, Wisskirchen C, Herold S, Wolff T, Ziebuhr J, Pleschka S. Influenza virus-induced caspase-dependent enlargement of nuclear pores promotes nuclear export of viral ribonucleoprotein complexes. J Virol. 2015 Jun;89(11):6009-21. doi: 10.1128/JVI.03531-14. Epub 2015 Mar 25.Naguib MM, Kinne J, Chen H, Chan KH, Joseph S, Wong PC, Woo PC, Wernery R, Beer M, Wernery U, Harder TC.
Outbreaks of highly pathogenic avian influenza H5N1 clade 2.3.2.1c in hunting falcons and kept wild birds in Dubai implicate intercontinental virus spread.
J Gen Virol. 2015 Sep 7. doi: 10.1099/jgv.0.000274. [Epub ahead of print]Naguib MM, Arafa AS, El-Kady MF, Selim AA, Gunalan V, Maurer-Stroh S, Goller KV, Hassan MK, Beer M, Abdelwhab EM, Harder TC.
Evolutionary trajectories and diagnostic challenges of potentially zoonotic avian influenza viruses H5N1 and H9N2 co-circulating in Egypt.
Infect Genet Evol. 2015 Aug;34:278-91. doi: 10.1016/j.meegid.2015.06.004. Epub 2015 Jun 3.Patil HP, Murugappan S, de Vries-Idema J, Meijerhof T, de Haan A, Frijlink HW, Wilschut J, Hinrichs WL, Huckriede A. Comparison of adjuvants for a spray freeze-dried whole inactivated virus influenza vaccine for pulmonary administration. Eur J Pharm Biopharm. 2015 Jun;93:231-41.Preusse, M., Schughart, K., Wilk, E., Klawonn, F., and Pessler, F. (2015). Hematological parameters in the early phase of influenza A virus infection in differentially susceptible inbred mouse strains. BMC Res Notes 8, 225.
Punyadarsaniya D, Winter C, Mork AK, Amiri M, Naim HY, Rautenschlein S, Herrler G.Precision-cut intestinal slices as a culture system to analyze the infection of differentiated intestinal epithelial cells by avian influenza viruses. J Virol Methods. 2015 Feb;212:71-5. doi: 10.1016/j.jviromet.2014.10.015. Epub 2014 Nov 13.Rahn J, Hoffmann D, Harder TC, Beer M.
Vaccines against influenza A viruses in poultry and swine: Status and future developments.
Vaccine. 2015 May 15;33(21):2414-24. doi: 10.1016/j.vaccine.2015.03.052. Epub 2015 Mar 31. Review.Reiche J, Böttcher S, Diedrich S, Buchholz U, Buda S, Haas W, Schweiger B, WolffT.
Low-level Circulation of Enterovirus D68-Associated Acute Respiratory Infections, Germany, 2014.
Emerg Infect Dis. 2015 May;21(5):837-41. doi: 10.3201/eid2105.141900.Reppe K, Radünzel P, Dietert K, Tschernig T, WolffT, Hammerschmidt S, Gruber AD, Suttorp N, Witzenrath M.
Pulmonary Immunostimulation with MALP-2 in Influenza Virus-Infected Mice Increases Survival after Pneumococcal Superinfection.
Infect Immun. 2015 Dec;83(12):4617-29. doi: 10.1128/IAI.00948-15. Epub 2015 Sep 14.Reuther P, Göpfert K, Dudek AH, Heiner M, Herold S, Schwemmle M.
Generation of a variety of stable Influenza A reporter viruses by genetic engineering of the NS gene segment. Sci Rep. 2015 Jun 12;5:11346. doi: 10.1038/srep11346.Schmier S, Mostafa A, Haarmann T, Bannert N, Ziebuhr J, Veljkovic V, Dietrich U, Pleschka S. In Silico Prediction and Experimental Confirmation of HA Residues Conferring Enhanced Human Receptor Specificity of H5N1 Influenza A Viruses. Sci Rep. 2015 Jun 19;5:11434. doi: 10.1038/srep11434.Silva IT, Carvalho A, Lang KL, Dudek SE, Masemann D, Durán FJ, Caro MSB, Rapp UR, Wixler V, Schenkel EP, Simões CMO, and Ludwig S (2015) In vitro and in vivo antitumor activity of a novel semisynthetic derivative of cucurbitacin B https://www.ncbi.nlm.nih.gov/pubmed/?term=In+vitro+and+in+vivo+antitumor+activity+of+a+novel+semisynthetic+derivative+of+cucurbitacin+BPLoS ONE,10:e0117794Stech O, Veits J, Abdelwhab el-SM, Wessels U, Mettenleiter TC, Stech J.
The Neuraminidase Stalk Deletion Serves as Major Virulence Determinant of H5N1 Highly Pathogenic Avian Influenza Viruses in Chicken. Sci Rep. 2015 Aug 26;5:13493. doi: 10.1038/srep13493.Shin, D.L., Hatesuer, B., Bergmann, S., Nedelko, T., and Schughart, K. (2015). Protection from Severe Influenza Virus Infections in Mice Carrying the Mx1 Influenza Virus Resistance Gene Strongly Depends on Genetic Background. J Virol 89, 9998-10009.Shpacovitch V, Temchura V, Matrosovich M, Hamacher J, Skolnik J, Libuschewski P, Siedhoff D, Weichert F, Marwedel P, Muller H, Uberla K, Hergenroder R, Zybin A. 2015. https://www.ncbi.nlm.nih.gov/pubmed/?term=Application+of+surface+plasmon+resonance+imaging+technique+for+the+detection+of+single+spherical+biological+submicrometer+particles.Application of surface plasmon resonance imaging technique for the detection of single spherical biological submicrometer particles. Anal Biochem 486:62-69.Sid H, Benachour K, Rautenschlein S. Co-infection with Multiple Respiratory Pathogens Contributes to Increased Mortality Rates in Algerian Poultry Flocks. Avian Dis. 2015 Sep;59(3):440-6.Stoel M, Pool J, de Vries-Idema J, Zaaraoui-Boutahar F, Bijl M, Andeweg AC, Wilschut J, Huckriede A. Innate responses induced by whole inactivated virus or subunit influenza vaccines in cultured dendritic cells correlate with immune responses in vivo. PLoS One. 2015 May 1;10(5):e0125228. van Doorn E, Liu H, Huckriede A, Hak E.
Safety and tolerability evaluation of the use of Montanide ISA™51 as vaccine adjuvant: A systematic review. Hum Vaccin Immunother. 2015 Sep 17:1-11.Van Poucke S, Doedt J, Baumann J, Qiu Y, Matrosovich T, Klenk HD, Van Reeth K, Matrosovich M. 2015.
Role of Substitutions in the Hemagglutinin in the Emergence of the 1968 Pandemic Influenza Virus. J Virol 89:12211-12216.Verhelst,J., Spitaels, J., Nürnberger, C., De Vlieger, D., Ysenbaert, T., Staeheli, P., Fiers, W., & Xavier Saelens. Functional comparison of Mx1 from two different mouse species reveals the involvement of loop L4 in the antiviral activity against influenza A viruses. J. Virol. 89: 10879-10890 (2015)von Recum-Knepper J, Sadewasser A, Weinheimer VK, Wolff T.
Fluorescence-Activated Cell Sorting-Based Analysis Reveals an Asymmetric Induction of Interferon-Stimulated Genes in Response to Seasonal Influenza A Virus.
J Virol. 2015 Jul;89(14):6982-93. doi: 10.1128/JVI.00857-15. Epub 2015 Apr 22.Warnking K, Klemm C, Löffler B, Niemann S, van Krüchten A, Peters G, Ludwig S, and Ehrhardt C (2015). Super-infection with Staphylococcus aureus inhibits influenza virus-induced type I IFN signalling through impaired STAT1-STAT2 dimerization. Cellular Microbiology. 17, 303-317Weber M, Sediri H, Felgenhauer U, Binzen I, Bänfer S, Jacob R, Brunotte L, García-Sastre A, Schmid-Burgk JL, Schmidt T, Hornung V, Kochs G, Schwemmle M, Klenk HD, Weber F.
Influenza virus adaptation PB2-627K modulates nucleocapsid inhibition by the pathogen sensor RIG-I.
Cell Host Microbe. 2015 Mar 11;17(3):309-19. doi: 10.1016/j.chom.2015.01.005. Epub 2015 Feb 19.Wedde M, Biere B, Wolff T, Schweiger B.Evolution of the hemagglutinin expressed by human influenza A(H1N1)pdm09 and A(H3N2) viruses circulating between 2008-2009 and 2013-2014 in Germany. Int J Med Microbiol. 2015 Oct;305(7):762-75. doi: 10.1016/j.ijmm.2015.08.030. Epub 2015 Aug 21. Wendel, I., Rubbenstroth, D., Doedt, J., Kochs, G., Wilhelm, J., Staeheli, P., Klenk, H., & M.Matrosovich. The avian-origin PB1 gene segment facilitated replication and transmissibility of the H3N2/1968 pandemic influenza virus. J. Virol. 89: 4170-4179 (2015)Wendel I, Matrosovich M, Klenk HD. 2015.
SnapShot: Evolution of Human Influenza A Viruses. Cell Host & Microbe 17:416-416.e411.Wessels U, Stech O, Abdelwhab el-SM, Judel A, Mettenleiter TC, Stech J.
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