Department of Medical Microbiology
University Medical Center Groningen

P.O. Box 30001, HPC EB88

NL-9700 RB Groningen

Visiting address:
A. Deusinglaan 1
NL-9713 AV Groningen
Phone: +31 50 3632714

Research Interests:
My research interests center on the development of vaccines against respiratory viruses, in particular influenza. Integrating knowledge of the relevant correlates of immune protection with recent insights in immunology, in particular mechanisms of innate immunology, my group attempts to take a rational approach towards the design of novel influenza vaccine modalities and formulations.  Our research activities can be divided into three major research lines. Using systems immunology techniques we try to find new leads for the development of improved vaccines. Among others, we have set up an in vitro vaccine evaluation system based on human PBMCs which can aid in the selection of promising vaccine candidates.
For the generation of universal influenza vaccines we re-evaluate old and design new vaccine formulations containing conserved virus antigens to evoke broadly reactive humoral and cellular immune responses. These activities we pursue in the context of the FP7 Project ‘UNISEC’ of which I am co-coordinator. In collaboration with my colleagues Professor H.W. Frijlink and Dr. W.L.J. Hinrichs from the Department of Pharmacy, University of Groningen, my group works onstabilization of influenza vaccines to increase vaccine shelf life and to enable vaccine administration via new, effective and patient-friendly ways like inhalation and sublingual delivery.