Inflammation is the body’s defense response to any damage or trauma, and is characterized by redness, heat, swelling, and pain. To eliminate the harm causing agents and repair the damaged tissue circulating leukocytes interact with the structurally changed endothelium and transmigrate and accumulate at the site of inflammation. While the inflammatory response is beneficial and host-protective, deregulated inflammation is a pathologic and harmful condition.
The Institute of Medical Biochemistry investigates various aspects of the inflammatory process. Our goal is to understand inflammation and develop methods to control the inflammatory response. Specifically, we analyze how endothelial cells regulate exocytosis of inflammatory mediators that are stored in specialized secretory granules; how endothelial and epithelial cells establish and regulate cell-cell contacts in the course of their polarization; and how chemoattractant receptors modulate leukocyte adhesion and transmigration.
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The contact address of the Institute of Medical Biochemistry is displayed below.
Institut für Medizinische Biochemie - Institute of Medical Biochemistry
phone +49 251 835-2118 / Fax - 6748
e-mail: hentrey at uni-muenster.de