A05: Publications


  1. Rutten BPF, Vermetten E, Vinkers CH, Ursini G, Daskalakis NP, Pishva E, de Nijs L, Houtepen LC, Eijssen L, Jaffe AE, Kenis G, Viechtbauer W, van den Hove D, Schraut KG, Lesch KP, Kleinman JE, Hyde TM, Weinberger DR, Schalkwyk L, Lunnon K, Mill J, Cohen H, Yehuda R, Baker DG, Maihofer AX, Nievergelt CM, Geuze E, Boks MPM (2018)
    Longitudinal analyses of the DNA methylome in deployed military servicemen identify susceptibility loci for post-traumatic stress disorder. Mol Psychiatry. 23(5):1145-1156. doi: 10.1038/mp.2017.120.
  2. Kiser DP, Popp S, Schmitt-Böhrer AG, Strekalova T, van den Hove DL, Lesch KP, Rivero O (2018)
    Early-life stress impairs developmental programming in Cadherin 13 (CDH13)-deficient mice. Prog Neuropsychopharmacol Biol Psychiatry. 89:158-168. doi: 10.1016/j.pnpbp.2018.08.010. [Epub ahead of print].
  3. Auth CS, Weidner MT, Popp S, Strekalova T, Schmitt-Böhrer AG, van den Hove D, Lesch KP, Waider J (2018)
    Differential anxiety-related behaviours and brain activation in Tph2-deficient female mice exposed to adverse early environment. Eur Neuropsychopharmacol. pii: S0924-977X(18)30288-8. doi: 10.1016/j.euroneuro.2018.07.103.
  4. Riemens RJM, van den Hove DLA, Esteller M, Delgado-Morales R (2018)
    Directing neuronal cell fate in vitro: Achievements and challenges. Prog Neurobiol. 168:42-68. doi: 10.1016/j.pneurobio.2018.04.003.


  1. Leibold NK, van den Hove D, Viechtbauer W, Kenis G, Goossens L, Lange I, Knuts I, Smeets HJ, Myin-Germeys I, Steinbusch HW, Schruers KR (2017)
    Amiloride-sensitive cation channel 2 genotype affects the response to a carbon dioxide panic challenge. J Psychopharmacol. 31(10):1294-1301. doi: 10.1177/0269881116686880.
  2. Vangeel EB, Pishva E, Hompes T, van den Hove D, Lambrechts D, Allegaert K, Freson K, Izzi B, Claes S (2017)
    Newborn genome-wide DNA methylation in association with pregnancy anxiety reveals a potential role for GABBR1. Clin Epigenetics. 9:107. doi: 10.1186/s13148-017-0408-5.
  3. Bodden C, van den Hove D, Lesch KP, Sachser N (2017)
    Impact of varying social experiences during life history on behaviour, gene expression, and vasopressin receptor gene methylation in mice. Sci Rep. 7(1):8719. doi: 10.1038/s41598-017-09292-0.


  1. Leibold NK, van den Hove DL, Viechtbauer W, Buchanan GF, Goossens L, Lange I, Knuts I, Lesch KP, Steinbusch HW, Schruers KR (2016)
    CO2 exposure as translational cross-species experimental model for panic. Transl Psychiatry 6(9):e885. doi: 10.1038/tp.2016.162.


  1. Gutknecht L, Popp S, Waider J, Sommerlandt FMJ, Göppner C, Post A, Reif A, van den Hove D, Strekalova T, Schmitt A, Colaco MBN, Sommer C, Palme R, Lesch KP (2015)
    Interaction of brain 5-HT synthesis deficiency, chronic stress and sex differentially impact emotional behavior in Tph2 knockout mice. Psychopharmacol 232:2429-2441.
  2. Strekalova T, Evans M, Costa-Nunes J, Bachurin S, Yeritsyan N, Couch Y, Steinbusch HM, Köhler ES, Lesch KP, Anthony DC (2015)
    Tlr4 upregulation in the brain accompanies depression- and anxiety-like behaviors induced by a high-cholesterol diet. Brain Behav Immun 48:42-7. doi: 10.1016/j.bbi.2015.02.015. Epub 2015 Feb 21.
  3. O’Dushlaine C, Rossin L, Lee PH, Duncan L, Parikshak NN, Newhouse S, Ripke S, Neale BM, Purcell SM, ..., Lawson WB, Leboyer M, Ledbetter DH, Lencz T, Lesch KP,  DF, Lewis CM, Li J, Lichtenstein P, Lieberman JA, Lin DY, Linszen DH, Liu C, …, Craddock N, Kendler KS, Weiss LA, Wray NR, Zhao Z, Geschwind DH, Sullivan PF, Smoller JW, Holmans PA, Breen G, The Network and Pathway Analysis Subgroup of the Psychiatric Genomics Consortium (2015)
    Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways. Nat Neurosci 18:199-209.
  4. Leibold NK, van den Hove DLA, Esquivel G, De Cort K, Goossens L, Strackx E, Buchanan GF, Steinbusch HWM, Lesch KP, Schruers KRJ (2015)
    The brain acid-base homeostasis and serotonin: A perspective on the use of carbon dioxide as human and rodent experimental model of panic. Prog Neurobiol 129:58-78.
  5. Blum R, Lesch KP (2015)
    Parkinson's disease, anxious depression and serotonin - zooming in on hippocampal neurogenesis. J Neurochem. 135:441-4.


  1. van den Hove DL, Leibold NK, Strackx E, Martinez-Claros M, Lesch KP, Steinbusch HW, Schruers KR, Prickaerts J (2014)
    Prenatal stress and subsequent exposure to chronic mild stress in rats; interdependent effects on emotional behavior and the serotonergic system. Eur Neuropsychopharmacol 24:595-607.
  2. Laas K, Reif A, Akkermann K, Kiive E, Domschke K, Lesch KP, Veidebaum T, Harro J. (2014)
    Interaction of the neuropeptide S receptor gene Asn107Ile variant and environment: contribution to affective and anxiety disorders, and suicidal behaviour. Int J Neuropsychopharmacol 17:541-552
  3. Jakob S, Schraut KG, Schmitt AG, Scholz CJ, Ortega G, Steinbusch HW, Lesch KP, van den Hove DL (2014)
    Differential effects of prenatal stress in female 5-Htt-deficient mice: towards molecular mechanisms of resilience. Dev Neurosci 36:454-464.
  4. Schraut KG, Jakob SB, Weidner MT, Schmitt AG, Scholz CJ, Strekalova T, El Hajj N, Eijssen LMT, Domschke K, Reif A, Haaf T, Ortega G, Steinbusch HWM, Lesch KP*, van den Hove DL* (2014)
    Prenatal stress-induced programming of genome-wide promoter DNA methylation in 5-HTT deficient mice. Translational Psychiatry 4:e473 *equal contribution.


  1. Waider J, Proft F, Langlhofer G, Asan E, Lesch KP, Gutknecht L (2013)
    GABA concentration and GABAergic neuron populations in limbic areas are differentially altered by brain serotonin deficiency in Tph2 knockout mice. Histochem Cell Biol 24:1225-1235.
  2. van den Hove DLA, Kenis G, Brass A, Rutten BPF, Bruschettini M, Blanco CE, Lesch KP, Steinbusch HWM, Prickaerts J (2013)
    Vulnerability versus resilience to prenatal stress in male versus female Sprague-Dawley rats; implications from gene expression profiles in the hippocampus and frontal cortex. Eur Neuropsychopharmacol 23:1226-46.
  3. Karabeg MM, Grauthoff S, Kollert S, Weidner M, Heiming RS, Jansen F, Popp S, Lesch KP, Sachser N, Schmitt AG, Lewejohann L (2013)
    5-HTT deficiency impacts the expression of different markers of neuroplasticity and increases stress sensitivity resulting in altered spatial learning performance. PloS One 8:e78238
  4. Smoller JW, Craddock N, Kendler K, Lee PH, Neale BM,, … Lesch KP, …, Craddock N, Kendler K, Cross-Disorder Group of the Psychiatric Genomics Consortium (2013)
    Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Lancet 381:1371-1379.
  5. Lee SH, Ripke S, Neale BM, Faraone SV, …, Lesch KP, …, Craddock N, Sullivan PF, Smoller JW, Kendler KS, Wray NR, Cross-Disorder Group of the Psychiatric Genomics Consortium  (2013)
    Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet 45:984-94.


  1. Lewejohann L, Kloke V, Heiming RS, Jansen F, Kaiser S, Schmitt A, Lesch KP, Sachser N (2010)
    Social status and day-to-day behaviour of male serotonin transporter knockout mice. Behav Brain Res. 25; 211(2): 220-8. 
  2. Scholz CJ, Jacob CP, Buttenschon HN, Kittel-Schneider S, Boreatti-Hümmer A, Zimmer M, Walter U, Lesch KP, Mors O, Kneitz S, Deckert J, Reif A (2010) 
    Funcitonal variants of TSPAN8 are associated with bipolar disorder and schizophrenia. Am J Med Genet B Neuropsychiatr Genet.153B(4):967-72.
  3. Dresler T, Ehlis A-C, Heinzel S, Renner TJ, Reif A, Bähne C, Heine M, Boreatti-Hümmer A, Jacob CP, Lesch KP, Fallgatter AJ (2010)
    Dopamine Transporter genotype impacts neurophysiological correlates of cognitive response control in an adult sample of patients with ADHD; Neuropsychopharmacology 35: 2193-2202
  4. Kriegebaum C, Gutknecht L, Bartke L, Reif A,  Buttenschon AN,  Mors O, Lesch KP,  Schmitt A (2010)
    The expression of the transcription factor FEV in adult human brain and its association with affective disorders. Journal of Neural Transmission 117 (7): 831-836 
  5. Kriegebaum C, Gutknecht L, Song NN,  Huang Y, Schmitt A, Reif A, Ding YQ,  Lesch KP (2010)
    Brain-specific conditional and time-specific inducible Tph2 knockout mice possess normal serotonergic gene expression in the absence of serotonin during adult life. Neurochemistry International 57: 512-517
  6. Laas K, Reif A, Herterich S,  Eensoo D,  Lesch KP,  Harro J (2010)
    The effect of a functional NOS1 promoter polymorphism on impulsivity is moderated by platelet MAO activity; Psychopharmacology 209 (3) 255-261
  7. Landaas ET, Johansson S, Jacobsen KK, Ribasés M, Bosch R, Sánchez-Mora C,  Fernàndez-Castillo N, Bayés M, Casas M,  Jacob CP, Boreatti-Hümmer A,  Heine M, Kreiker S,  Groß-Lesch S, Lesch KP, Kiemeney LA, Kooij JJS, Kan C, Hoogman M,  Buitelaar JK, Faraone SV, Halmøy A, Ramos-Quiroga JA, Cormand B,  Reif A,  Franke B, Mick E, Knappskog PM, Haavik J (2010)
    An international multicenter association study of the serotonin transporter gene in persistent ADHD; Genes, Brain and Behavior 9(5): 449-458
  8. Lazary J, Juhasz G, Anderson I, Jacob CP, Nguyen TT, Lesch KP, Reif A, Deakin JFW,  Bagdy G (2010)
    Epistatic interaction of CREB1 and KCNJ6 on rumination and negative emotionality; in press at European Neuropsychopharmacology
  9. Lesch KP, Selch S, Renner TJ, Jacob CP, Nguyen TT, Hahn T, Romanos M,  Walitza S, Shoichet S, Dempfle A, Heine M, Boreatti-Hümmer A, Romanos J, Gross-Lesch S, Zerlaut H, Wultsch T, Heinzel S, Fassnacht M, Fallgatter AJ,  Allolio B,  Schäfer H, Warnke A, Reif A, Ropers HH, Ullmann R (2010)
    Genome-wide copy number variation analysis in ADHD: association with neuropeptide Y gene dosage in an extended pedigree; Molecular Psychiatry 16(5):491-503
  10. Reif A, Kiive E, Kurrikoff T, Paaver M, Herterich S, Konstabel K, Tulviste T,  Lesch KP,  Harro J (2010)
    A functional NOS1 promoter polymorphism interacts with adverse environment on functional and dysfunctional impulsivity; in press at Psychopharmacology 214(1):239-48
  11. Sánchez-Mora C, Ribasés M, Ramos-Quiroga JA, Casas M, Bosch R, Boreatti-Hümmer A, Heine M, Jacob CP, Lesch KP, Fasmer OB,  Knappskog PM,  Sandra Kooij JJ,  Kan C, Buitelaar JK, Mick E, Asherson P, Faraone SV, Franke B, Johansson S,  Haavik J,  Reif A, Bayés M, Cormand B (2010)
    Meta-analysis of brain-derived neurotrophic factor p.Val66Met in adult ADHD in four european populations; American Journal of Medical Genetics 153B(2): 512-523
  12. Hahn T, Dresler T, Plichta MM, Ehlis AC, Ernst LH, Markulin F, Polak T, Blaimer M, Deckert J, Lesch KP, Jakob PM, Fallgatter AJ (2010)
    Functional Amygdala-Hippocampus Connectivity During Anticipation of Aversive Events is Associated with Gray's Trait "Sensitivity to Punishment". Biol Psychiatry. 68(5) 459-464
  13. Hahn T, Heinzel S, Dresler T, Plichta MM, Renner TJ, Markulin F, Jakob PM, Lesch KP, Fallgatter AJ (2010)
    Association between reward-related activation in the ventral striatum and trait reward sensitivity is moderated by dopamine transporter genotype. in press at Human Brain Mapping.
  14. Rivero O, Reif A, Sanjuán J, Moltó MD, Kittel-Schneider S, Nájera C, Töpner T, Lesch KP (2010)
    Impact of the AHI1 gene on the vulnerability to schizophrenia: a case-control association study. PLoS One. 18;5(8):e12254
  15. Ehlis AC, Bauernschmitt K, Dresler T, Hahn T, Herrmann MJ, Röser C, Lesch KP, Fallgatter AJ, Renner TJ. (2010)
    Influence of a genetic variant of the Neuronal Growth Associated Protein Stathmin 1 on cognitive and affective control processes – An event-related potential study. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 156B(3):291-302
  16. Hahn T, Marquand AF, Ehlis AC, Dresler T, Kittel-Schneider S, Jarczok T, Lesch KP, Jakob PM, Mourao-Miranda J, Brammer M, Fallgatter AJ (2010)
    Integrating neurobiological markers of depression. in press at Archives of General Psychiatry.
  17. Hahn T, Heinzel S, Plichta MM, Reif A, Lesch KP, Fallgatter AJ (2010)
    Neurovascular Coupling in the Human Visual Cortex Is Modulated by Cyclooxygenase-1 (COX-1) Gene Variant. in press at Cereb Cortex.


  1. Gutknecht L, Araragi N, Merker S, Waider J, Sommerlandt FMJ, Mlinar B, Baccini G, Mayer U, Proft F, Post A, Hamon M, Schmitt AG, Corradetti R, Lanfumey L, Lesch KP (2012)
    Brain serotonin deficiency following Tph2 inactivation impacts somatic development but not raphe neuron specification. PloS One 7:e43157
  2. Kurrikoff T, Lesch KP, Kiive E, Konstabel K, Herterich S, Veidebaum T, Reif A, Harro J (2012)
    Association of a functional variant of the nitric oxide synthase 1 gene with personality, anxiety, and depressiveness. Development and Psychopathology 24:1225-1235
  3. Boulle F, van den Hove DL, Jakob SB, Rutten BP, Hamon M, van Os J, Lesch KP, Lanfumey L, Steinbusch HW, Kenis G (2012)
    Epigenetic regulation of the BDNF gene: implications for psychiatric disorders. Mol Psychiatry 17:584-596
  4. Lesch KP, Araragi N, Waider J, van den Hove D, Gutknecht L (2012)
    Targeting brain serotonin synthesis: insights into neurodevelopmental disorders with long-term outcomes related to negative emotionality, aggression and antisocial behavior. Philos Trans R Soc Lond B Biol Sci 367:2426-2443
  5. Lesch KP, Waider J (2012)
    Serotonin in the modulation of neural plasticity and networks: implications for neurodevelopmental disorders. Neuron 76:175-191


  1. Dresler T, Ehlis AC, Plichta MM, Richter MM, Jabs B, Lesch KP, Fallgatter AJ (2009)
    Panic disorder and a possible treatment approach by means of high-frequency r-TMS: A case report. World J Biol Psychiatry  (4 Pt 3):991-997. 
  2. Heiming RS, Jansen F, Lewejohann L, Kaiser S, Schmitt A, Lesch KP, Sachser N (2009)
    Living in a dangerous world: the shaping of behavioral profile by early environment and 5-HTT genotype. Front Behav Neurosci.3:26.
  3. Jansen F, Heiming RS, Lewejohann L, Touma C, Palme R, Schmitt A, Lesch KP, Sachser N (2009)
    Modulation of behavioural profile and stress response by 5-HTT genotype and social experience in adulthood. Behav Brain Res. 11; 207(1): 21-29.  
  4. Reif A, Jacob CP, Rujescu D, Herterich S, Lang S, Gutknecht L, Baehne CG, Strobel A, Freitag CM, Giegling I, Romanos M, Hartmann A, Rösler M, Renner TJ, Fallgatter AJ, Retz W, Ehlis AC, Lesch KP (2009)
    Influence of functional variant of neuronal nitric oxicde synthase on impulsive behaviors in humans. Arch Gen Psychiatry (1): 41-50.  
  5. Ribasés M, Bosch R, Hervás A, Ramos-Quiroga AR, Sánchez-Mora C, Bielsa A, Gastaminza X, Guijarro-Domingo S, Nogueira M, Gómez-Barros N, Kreiker S, Groß-Lesch S, Jacob CP, Lesch KP, Reif A, Johansson S, Plessen KJ, Knappskog PM, Haavik J, Estivill X, Casas M, Bayés M, Cormand B (2009)
    Case-control study of six genes asymmetricaly expressed in the two cerebral hemispheres: association of BAIAP2 with attention-deficit/hyperactivity disorder. Biol Psychiatry 15;66(10):926-934. 


  1. Lesch KP, Timmesfeld N, Renner TJ, Halperin R, Röser C, Nguyen TT, Craig DW, Romanos J, Heine M, Meyer J, Freitag C, Warnke A, Romanos M, Schäfer H, Walitza S, Reif A, Stephan DA, Jacob C (2008)
    Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linage studies. J Neural Transm 115 (11): 1573-1585.