- Norkowski S., Schmidt M.A., and Rüter C. (2018) The species-spanning family of LPX-motif harboring effector proteins. Cell. Microbiol. 20(11):e12945.
- Benjamin Grabowski, M. Alexander Schmidt & Christian Rüter (2017) Immunomodulatory Yersinia outer proteins (Yops)–useful tools for bacteria and humans alike, Virulence. (doi: 10.1080/21505594.2017.1303588)
GomarascaM., MartinsT.F.C., Greune L., Hardwidge P.R., Schmidt M.A., and RüterC. (2017) Bacterium-derived CPP deliver gentamicin to kill intracellular pathogens. Antimicrob. Agents Chemother. 61(4):e02545-16.
- Norkowski S., Körner B., Greune L., Stolle A-S., Lubos M-L., Hardwidge P.R., Schmidt M.A. and Rüter C. (2017) Bacterial LPX motif-harboring virulence factors constitute a species-spanning family of cell-penetrating effectors. Cell. Mol. Life Sci. 75(12):2273–2289.
- Rüter C., and Schmidt M.A. (2017) Cell-Penetrating Bacterial Effector Proteins: Better Tools than Targets. Trends in Biotechnology. 35(2):109-120.
We have identified several T3SS-effectors of Gram-negative pathogens as ’cell-penetrating effector proteins (CPE)’. CPE derived from E. coli, Yersinia, and Shigella will be characterized for cellular uptake, intracellular trafficking, modulation of signaling pathways, their possibilities for heterologous cargo transport, and their effects on cellular barriers with and without shear stress under flow in 2-D and 3-D models. Furthermore, we will address potential therapeutic options in murine models of autoimmune diseases
Research area: Infection biology
Dr. rer. nat. Christian Rüter (since 07/2016)
Funding period: July 2012 - June 2020