The role of MAPK in influenza virus (IV) replication and bacterial super-infection
Invasion of influenza viruses (IV) and/or Staphylococcus aureus into cells of epithelial and endothelia barriers results in the activation of the Raf/MEK/ERK kinase cascade. It was previously shown that active ERK promotes nuclear export of IV genomes thereby supporting viral replication. The detailed mechanisms will now be further elucidated. Furthermore, regulation and function of the ERK pathway upon IV and/or S. aureus infection will be explored with respect to changes in immune responses, inflammation and pathogen load. Finally, suitability of the pathway as a target for anti-pathogen therapy will be evaluated.