Research areas: Vascular Matrix Biology, Integrin-Matrix Interaction, Protein Chemistry
Funding periodt: January 2014 - June 2020
Interplay of integrin-mediated adhension and MMP14-driven proteolysis in matrix barrier-breaking invadopodia of tumour cells
The molecular linkage between b1 integrins and MMP14 within invadopodia of melanoma cells will be disclosed at protein-chemical and cellular level. To study their functional linkage, integrin-dependent localization and activity of MMP14 within invadopodia will be analyzed. Inhibition of melanoma invasion by individually targeting MMP14 will be compared with an approach of dual targeting both b1 integrins and MMP14 with novel bifunctional integrin- and MMP14-targeting (BIMT) molecules at the cellular level. Translationally, BIMTs will be tested for their potential to inhibit melanoma invasion in chicken CAM and murine lung assay.
Prof. Dr. rer. nat. Johannes Eble
Institute of Physiological Chemistry and Pathobiochemistry
Phone: +49 (0) 251 83 55591
Principal investigator: A 09