Immune-cell interactions with endothelial cells and pericytes at the blood-brain-barrier: Mechanisms and consequences
Our project investigates mechanisms how lymphocytes breach the blood-brain-barrier and contribute to CNS inflammation. In the first part, we aim to reveal the key influencing factors as well as underlying mechanisms of immune cell-mediated brain endothelial barrier disruption under static and under flow conditions. In the second part, we aim to study the role of pericytes as cellular constituents of the blood-brain-barrier during the process of immune cell transmigration in the context of CNS autoimmunity, especially with regard to potential interactions with autoreactive T cells shaping T cell activity and migratory behaviour.
- , Gross CC (2013) Modulation of IL-2Rα with daclizumab for treatment of multiple sclerosis. Nature Rev Neurol 9: 394-404.
Clinic for general neurology - Inflammatory disorders of the nervous system
Phone: +49 (0) 251 980 29-00
Principal investigator: A 03 (since 07/2016)