Identification and functional analysis of barrier-breaking genes in myeloid cells
Research area: Oncology, biology of myeloid cellsProf. Dr. med. Carsten Müller-TidowFunding period: July 2012 - December 2014
SummaryIdentification and functional analysis of barrier-breaking genes in myeloid cells Genes and mechanisms that determine the invasive potential of myeloid and myelo-monocytic cells remain incompletely understood. In this project, we will systematically identify and characterize genes and functional mechanisms that determine the invasiveness of myeloid cells with a focus on myeloid leukemia blasts. S100P functions in myeloid invasiveness will be analyzed in detail along with genes identified in a shRNA library screen. Functional analyses in mouse models will determine the relevance for overcoming natural barriers for myeloid cells in vivo.
- Bäumer N, Krause A, Köhler G, Lettermann S, Evers G, Hascher A, Bäumer S, Berdel WE, Müller-Tidow C, Tickenbrock L (2014) Proteinase-Activated Receptor 1 (PAR1) regulates leukemic stem cell functions. PLoS One 9 (4): e94993. [doi: 10.1371/journal.pone.0094993. eCollection 2014]
- Schoofs T, Berdel WE, Mü̈ller-Tidow C (2014) Origins of aberrant DNA methylation in acute myeloid leukemia. Leukemia 28: 1–14.
Principal investigatorProf. Dr. med. Carsten Müller-Tidow
Medical Clinic of Internal Medicine A (Hematology, Oncology, and Oneumology)
Phone: +49 (0) 251 83 52995
Principal investigator: A 07