Body and Brain
In this research area, we examine how the interaction between the body and the brain shape neural function and contribute to neurological disease. One focus is on disorders in which immune processes directly alter neuronal communication and brain activity, such as multiple sclerosis and autoimmune anti-NMDA receptor encephalitis. Rather than viewing these diseases solely through their molecular or structural pathology, we study how immune-mediated changes affect cortical network dynamics and brain states across different stages of disease progression. Our goal is to identify early circuit dysfunction and mechanisms of resilience that may precede irreversible damage and clinical symptoms.
To address these questions, we combine advanced in vivo imaging and neurophysiological approaches. Using multiphoton microscopy (2-photon and 3-photon imaging), optogenetic manipulation, electrophysiology, and multimodal functional recordings, we aim to uncover disease-related network alterations and their relation to sensory, cognitive and neuropsychiatric symptoms. By linking translational animal models with state-of-the-art neurophysiological methods, we seek to contribute to the development of advanced diagnostic and therapeutic approaches.