The amygdala as part of the limbic system plays an important role in the processing, evaluation and retrieval of emotional and threatening environmental events.  Anxiety disorders (e.g. panic attacks, PTSD, phobias etc.) have been attributed to dysfunctions of the amygdala and related brain network structures (prefrontal cortex, hippocampus, bed nucleus of the stria terminalis, paraventricular thalamus). Our experimental studies, focusing on the neural mechanisms of fear memory and extinction, will be performed using a wide spectrum of behavioral, electrophysiological, pharmacological, and optogenetical  methods and techniques.

Research Projects

Project Staff Colaborators
Contribution of CRF and 5-HT in the anterodorsal BNST on phasic and sustained fear in freely behaving mice Seidenbecher
Distinct circuits of the extended amygdala regulating fear generalization and extinctionPape  
Cell type-specificity of endocannabinoid signaling in amygdala-BNST projections regulating sustained fearPape Lutz
Impact of the Neuropeptide S system and NPS-receptor polymorphisms on fear and anxietyJüngling  
The BDNF system as mediator for stress impaired fear acquisition, extinction and late fearLange Andreatta
Pathways and mechanisms of NPY and Y2 receptors for controlling conditioned fearPape,