Robert-Koch-Str. 27 a
+ 49 251-83.55553 (phone)
+ 49 251-83.55551 (fax)

Research Projects

  1. Functional circuit analysis of the extended amygdala
    in relation to sustained fear

  • Curriculum vitae

    Business Address: Institute of Physiology I,
    Westfälische Wilhelms-University
    Robert-Koch-Str. 27a
    D-48149 Münster, Germany
    Phone number: +49(0251) 8355553

    Education and training

    2002 school leaving examination
    10/2002-02/2006 Bachelor of Science (biology/chemistry), Ruhr-University, Bochum
    Bachelor thesis: „Der Einfluss von FCS behandelten Astrozyten auf Na+-Ströme in Nervenzellen aus dem Hippocampus postnataler Ratten“
    10/2002-01/2008 Dipl. Biol., Ruhr-University, Bochum
    Diploma thesis: „In vivo Untersuchungen zur Interaktion der Geruchsrezeptoren der Taufliege Drosophila melanogaster mit Komponenten der Signaltransduction“
    03/2006-11/2008 Master of Education (biology/chemistry), Ruhr-University, Bochum
    Master thesis: „Der Einfluss von bFGF, NT-3 und T3 sowie von Trk-Rezeptor-Blockern und Antikörpern auf die Na+-Stromdichte in kultivierten Hippocampusneuronen“
    10/2008-06/2012 scholarship of the Otto Creuzfeldt Center for Cognitive and Behavioral Neuroscience (OCC), Westfälische Wilhelms-University, Münster
    10/2008-06/2012 Dr. rer. nat. at the department of physiology I (Prof. Dr. Pape), Westfälische Wilhelms-University, Münster
    Thesis title: “Synaptic plasticity and the role of the 65-kDa isoform of glutamic acid decarboxylase in GABAergic synaptic transmission in the lateral amygdala related to fear memory”
    Since 07/2012 Postdoctoral research associate at the department of physiology I, Westfälische Wilhelms-University, Münster
  • Publications


    1. Haaker J, Maren S, Andreatta M, Merz CJ, Richter J, Richter SH, Meir Drexler S, Lange MD, Jüngling K, Nees F,Seidenbecher T, Fullana MA, Wotjak CT, Lonsdorf TB (2019)
      Making translation work: Harmonizing cross-species methodology in the behavioural neuroscience of Pavlovian fear conditioning.
      Neurosci Biobehav Rev. 107: 329-345. doi: 10.1016/j.neubiorev.2019.09.020.
    2. Klinke CM, Fiedler D, Lange MD, Andreatta M (2019)
      Evidence for impaired extinction learning in humans after distal stress exposure. Neurobiol Learn Mem. 22;167:107127.
    3. Verma D, Jamil S, Tasan RO, Lange MD, Pape HC (2019)
      Single stimulation of Y2 receptors in BNSTav facilitates extinction and dampens reinstatement of fear. Psychopharmacology (Berl). 236(1):281-291.
    4. Zimmermann T, Bartsch JC, Beer A, Lomazzo E, Guggenhuber S, Lange MD, Bindila L, Pape HC, Lutz B (2019)
      Impaired anandamide/palmitoylethanolamide signaling in hippocampal glutamatergic neurons alters synaptic plasticity, learning, and emotional responses. Neuropsychopharmacology. 44(8):1377-1388.


    1. Walter AL, Bartsch JC, Datunashvili M, Blaesse P, Lange MD, Pape HC (2018)
      Physiological Profile of Neuropeptide Y-Expressing Neurons in Bed Nucleus of Stria Terminalis in Mice: State of High Excitability. Front Cell Neurosci.5;12:393.


    1. Remmers F, Lange MD, Hamann M, Ruehle S, Pape HC, Lutz B (2017)
      Addressing sufficiency of the CB1 receptor for endocannabinoid-mediated functions through conditional genetic rescue in forebrain GABAergic neurons. Brain Struct Funct. 2017 Apr 9. doi: 10.1007/s00429-017-1411-5. [Epub ahead of print], PMID: 28393261. 
    2. Grünewald B, Lange MD, Werner C, O'Leary A, Weishaupt A, Popp S, Pearce DA, Wiendl H, Reif A, Pape HC, Toyka KV, Sommer C, Geis C (2017)
      Defective synaptic transmission causes disease signs in a mouse model of juvenile neuronal ceroid lipofuscinosis. Elife. pii: e28685.
    3. Waider J, Popp S, Lange MD, Kern R, Kolter JF, Kobler J, Donner NC, Lowe KR, Malzbender JH, Brazell CJ, Arnold MR, Aboagye B, Schmitt-Böhrer A, Lowry CA, Pape HC, Lesch KP (2017)
      Genetically driven brain serotonin deficiency facilitates panic-like escape behavior in mice. Transl Psychiatry. 3;7(10):e1246.


    1. Lange MD, Daldrup T, Remmers F, Szkudlarek HJ, Lesting J, Guggenhuber S, Ruehle S, Jüngling K, Seidenbecher T, Lutz B, Pape HC (2016)
      Cannabinoid CB1 receptors in distinct circuits of the extended amygdala determine fear responsiveness to unpredictable threat. Molecular Psychiatry 2016 Oct 4. doi: 10.1038/mp.2016.156. [Epub ahead of print], PMID: 27698427.


    1. Jüngling K, Lange MD, Szkudlarek H, Lesting J, Erdmann F, Doengi M, Kügler S, Pape HC (2015)
      Increased GABAergic efficacy of central amygdala projections to neuropeptide neurons in the brainstem during fear memory retrieval. Neuropsychopharmacoloy, 2015 May 4. doi: 10.1038/npp.2015.125. [Epub ahead of print]
    2. Erdmann F, Kügler S, Blaesse P, Lange MD, Skryabin BV, Pape HC, Jüngling K (2015)
      Neuronal expression of the human neuropeptide S receptor NPSR1 identifies NPS-induced calcium signaling pathways.
      PLoS One. 10(2):e0117319. doi: 10.1371/journal.pone.0117319. eCollection 2015.
    3. Igelhorst BA, Niederkinkhaus V, Karus C, Lange MD, Dietzel ID (2015)
      Regulation of neuronal excitability by release of proteins from glial cells.
      Philos Trans R Soc Lond B Biol Sci. 2015 Jul 5;370(1672). pii: 20140194. doi: 10.1098/rstb.2014.0194.
    4. Sosulina L, Strippel C, Romo-Parra H, Walter AL, Kanyshkova T, Sartori SB, Lange MD, Singewald N, Pape HC (2015)
      Substance P excites GABAergic neurons in the mouse central amygdala through neurokinin 1 receptor activation. J Neurophysiology. 114(4):2500-8.
    5. Igelhorst BA, Niederkinkhaus V, Karus C, Lange MD, Dietzel ID (2015)
      Regulation of neuronal excitability by release of proteins from glial cells. Philos Trans R Soc Lond B Biol Sci. 5;370(1672).


    1. Lange MD, Jüngling K, Paulukat L, Vieler M, Gaburro S, Sosulina L, Blaesse P, Sreepathi HK, Ferraguti F, Pape HC (2014)
      Glutamic acid decarboxylase 65: a link between GABAergic synaptic plasticity in the lateral amygdala and conditioned fear generalization.
      Neuropsychopharmacology 39(9):2211-20.


    1. M.D. Lange, M. Doengi, J. Lesting, H.-C. Pape, K. Jüngling (2012)
      A novel form of heterosynaptic long-term potentiation at interneuron-principal-neuron synapses in the amygdala requires nitric oxide signalling.
      J. Physiol. 590: 131-143
    2. F. Chauveau, M.D. Lange, K. Jüngling, J. Lesting, T. Seidenbecher, H.-C. Pape (2012)
      Prevention of stress-impaired fear extinction through neuropeptide S action in the lateral amygdala.
      Neuropsychopharmacology 37(7): 1588-99.