The aim of the experimental in situ and in vivo studies is to identify the alterations of intrinsic neuronal properties (ion channels, membrane receptors), network circuitry and modulation of neurons by neurotransmitters (acetylcholine, GABA, noradrenaline, and serotonin) in different thalamic nuclei (first and higher order, intralaminar) which underlie the switch from physiological sleep related activity (e.g. delta oscillations) to absence epilepsy-related spike-and-wave discharges (SWD) and play an important role in the development of chronic pain.
|Alterations of thalamic ion channels and activity in psychostimulant abuse (funded by DFG).
|Francisco J. Urbano
Optogentic control of epileptic seizures by influencing nodes and choke points (funded by DFG).
|Unraveling brain networks of absence epilepsy
|Seizure prediction and prevention
|Biomarkers for the ictogenesis of absence seizures