Organoids as kidney models
We generate kidney organoids from human pluripotent stem cells. These kidney organoids closely resemble the architecture and cellular composition of the native kidney, providing a valuable in vitro model to study physiological processes and kidney diseases.
Using kidney organoids, we investigate mechanisms and potential therapies for acute and chronic kidney injury, vascular development within organoids, and cellular reprogramming of kidney cells as a strategy for kidney regeneration.
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Kidney organoids derived from human induced pluripotent stem cells (hiPSCs).
Immunofluorescence analysis of a kidney organoid at day 21 for podocytes (PODXL), proximal tubule (LTL), distal tubule (CDH1) and nuclei (DAPI).Scale bars, 100 μm (left panel), 20 μm (right panels).