In cooperation with the Department of Pediatric Oncology, Hematology and Clinical Immunology in Düsseldorf, paired-end sequencing data of patients with AML and ALL are analyzed with respect to large genomic aberrations, so called structural variations. This includes detection and annotation of deletions, insertions, duplications, inversions and translocations of genomic sequences, which have potential to influence tumor growth and develpoment. One key aspect is the computational detection of artificially generated variations to optimize and speed up subsequent laboratory validation.

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