Reconstruction of clonal evolution

In the field of cancer research, analyzing the clonal evolution of a tumor is of major interest. The early identification of aggressive subclones can enable new therapeutic options. Therapy resistance might be detected prior to relapse, thus, having the potential to influence survival significantly. However, the actual reconstruction of clonal evolution on the basis of mutational data is not trivial, but a challenge for bioinformatics.

We currently have collaborations in the following clinical and theoretical research projects:

  • Analysis of clonal evolution in pediatric cases of Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML); cooperation with the Medizinische Hochschule Hannover (MHH, Dr. Gudrun Göhring)

  • Analysis of clonal evolution in cases of Multiple Myeloma (MM); cooperation with the Medical Clinic A of the UKM (PD Dr. Cyrus Khandanpour)

  • Analysis of clonal evolution in cases of pediatric T-cell lymphoblastic lymphoma; cooperation with the Clinic for Pediatric and Adolescent Medicine of the UKM (Univ.-Prof. Birgit Burkhardt)

  • Analysis of clonal expansion in the human male germline; cooperation with the Clinical Research Unit „Male Germ Cells: From Genes to Function“ (Univ.-Prof. Schlatt and PD Dr. Nina Neuhaus)

  • Optimization of algorithms for automatic reconstruction of clonal evolution; cooperation with the Institute of Computer Science of the WWU (Univ.-Prof. Xiaoyi Jiang)

First results of our work, analyzing clonal evolution in Burkitt's Lymphoma, have been published in Leukemia. Results regarding clonal evolution in MDS have been published in Nature Communications.

Contact: Dr. Sarah Sandmann-Varghese