Fachgebiet

• Medizinische Biometrie

Tätigkeitsschwerpunkte

• Methodische Forschung
• Studienplanung und -auswertung
• Biometrische Beratung
• Lehre

Statistische Schwerpunkte:

• Flexible, adaptive Studiendesigns
• Studien mit Zwischenanalysen
• Ereigniszeitanalyse

Klinische Schwerpunkte:

• Pädiatrische Onkologie und Hämatologie
• Seltene Erkrankungen

• Danzer MF, Faldum A, Simon T, Hero B, Schmidt R (2024). Confirmatory adaptive group sequential designs for clinical trials with multiple time-to-event outcomes in Markov models. Biometrical Journal, 66: e202300181.

• Feld J, Danzer MF, Faldum A, Schmidt R (2024). Two-sample survival tests based on control arm summary statistics. PLoS One. 2024; 19(6): e0305434.

• Danzer MF, Faldum A, Schmidt R (2023). On Variance Estimation for the One-Sample Log-Rank Test. Statistics in Biopharmaceutical Research 15(2): 433-443.

• Danzer MF, Feld J, Faldum A, Schmidt R (2022). Reference curve sampling variability in one-sample log-rank tests. PLoS ONE 17(7): e0271094.

• Stock A, Hancken CV, Kandels D, Kortmann RD, Dietzsch S, Timmermann B, Pietsch T, Bison B, Schmidt R, Pham M, Gnekow AK, Warmuth-Metz M (2022). Pseudoprogression Is Frequent After Front-Line Radiation Therapy in Pediatric Low-Grade Glioma: Results from the German Low-Grade Glioma Cohort. International Journal of Radiation Oncology – Biology – Physics 112(5): 1190-1202

• Danzer M, Terzer T, Berthold F, Faldum A, Schmidt R (2022). Confirmatory adaptive group sequential designs for single-arm phase II studies with multiple time-to-event endpoints. Biometrical Journal 64(2): 312-342.

• Feld J, Faldum A, Schmidt R (2021). Adaptive group sequential survival comparisons based on log-rank and pointwise test statistics. Statistical Methods in Medical Research 30(12): 2562–2581.

• Kerschke L, Faldum A, Schmidt R (2020). An improved one-sample log-rank test. Statistical Methods in Medical Research 9(10): 2814–2829.

• Kandels D, Pietsch T, Bison B, Warmuth-Metz M, Thomale UW, Kortmann RD, Timmermann B, Hernáiz Driever P, Witt O, Schmidt R*, Gnekow AK* (2020). Loss of efficacy of subsequent nonsurgical therapy after primary treatment failure in pediatric low-grade glioma patients—Report from the German SIOP-LGG 2004 cohort. International Journal of Cancer147(12): 3471-3489.
  * These authors contributed equally.

• Berthold F, Faldum A, Ernst A, Boos J, Dilloo D, Eggert A, Fischer M, Frühwald M, Henze G, Klingebiel T, Kratz C, Kremens B, Grug B, Leuschner I, Schmidt M, Schmidt R, Schumacher-Kuckelkorn R, von Schweinitz D, Schilling FH, Hteissen J, Volland R, Hero B, Simon T (2020). Extended induction chemotherapy does not improve the outcome for high-risk neuroblastoma patients. Results of the randomized open-label GPOH trial NB2004-HR. Annals of Oncology 31(3): 422-429.