1.The potassium channel K2P2.1 shapes the morphology and function of brain endothelial cells via actin network remodeling. Lichtenberg S, Vinnenberg L, Steffen F, Plegge I, Hanuscheck N, Dobelmann V, Gruchot J, Schroeter CB, Ramachandran H, Wasser B, Bachir D, Nelke C, Franz J, Riethmüller C, Tenzer S, Distler U, Vogelaar CF, Kusche-Vihrog K, Skryabin BV, Rozhdestvensky TS, Schwab A, Krutmann J, Rossi A, Budde T, Bittner S, Meuth SG, Ruck T. Nat Commun. 2025 Jul 18;16(1):6622. doi: 10.1038/s41467-025-61816-9. PMID: 40681505
2.CRISPR-Cas9 HDR optimization: RAD52, denatured, and 5'-modified DNA templates in knock-in mice generation. Skryabin BV, Braun DA, Kaiser H, Gubar L, Seeger B, Khanam T, Stegemann A, Pavenstädt H, Rozhdestvensky TS. iScience. 2025 Oct 20;28(11):113803. doi: 10.1016/j.isci.2025.113803. eCollection 2025 Nov 21. PMID: 41244575
3.Advancing 3Rs: The Mouse Estrus Detector (MED) as a Low-Stress, Painless, and Efficient Tool for Estrus Determination in MiceBelozertseva IV, Merkulovs DD, Kaiser H, Rozhdestvensky TS, Skryabin BV. Int J Mol Sci. 2024 Aug 30;25(17):9429. doi: 10.3390/ijms25179429. PMID: 39273375 Free PMC article.
4.Human model of primary carnitine deficiency cardiomyopathy reveals ferroptosis as a novel mechanism. Loos M, Klampe B, Schulze T, Yin X, Theofilatos K, Ulmer BM, Schulz C, Behrens CS, van Bergen TD, Adami E, Maatz H, Schweizer M, Brodesser S, Skryabin BV, Rozhdestvensky TS, Bodbin S, Stathopoulou K, Christ T, Denning C, Hübner N, Mayr M, Cuello F, Eschenhagen T, Hansen A. Stem Cell Reports. 2023 Nov 14;18(11):2123-2137. doi: 10.1016/j.stemcr.2023.09.002. Epub 2023 Oct 5. PMID: 37802072 Free PMC article.
5.A Carboxy-terminal Smarcb1 Point Mutation Induces Hydrocephalus Formation and Affects AP-1 and Neuronal Signalling Pathways in Mice. Brugmans AK, Walter C, Moreno N, Göbel C, Holdhof D, de Faria FW, Hotfilder M, Jeising D, Frühwald MC, Skryabin BV, Rozhdestvensky TS, Wachsmuth L, Faber C, Dugas M, Varghese J, Schüller U, Albert TK, Kerl K. Cell Mol Neurobiol. 2023 Oct;43(7):3511-3526. doi: 10.1007/s10571-023-01361-5. Epub 2023 May 23. PMID: 37219662 Free PMC article.
6.Ablation of C-type natriuretic peptide/cGMP signaling in fibroblasts exacerbates adverse cardiac remodeling in mice. Werner F, Prentki Santos E, Michel K, Schrader H, Völker K, Potapenko T, Krebes L, Abeßer M, Möllmann D, Schlattjan M, Schmidt H, Skryabin BV, Špiranec Spes K, Schuh K, Denton CP, Baba HA, Kuhn M. JCI Insight. 2023 Jul 10;8(13):e160416. doi: 10.1172/jci.insight.160416. PMID: 37227779 Free PMC article.
7.CRISPR/Cas9 Knock-Out in Primary Neonatal and Adult Cardiomyocytes Reveals Distinct cAMP Dynamics Regulation by Various PDE2A and PDE3A Isoforms. Skryabin EB, De Jong KA, Subramanian H, Bork NI, Froese A, Skryabin BV, Nikolaev VO. Cells. 2023 Jun 4;12(11):1543. doi: 10.3390/cells12111543. PMID: 37296663 Free PMC article.
8.Familial atrial fibrillation mutation M1875T-SCN5A increases early sodium current and dampens the effect of flecainide. O'Reilly M, Sommerfeld LC, O'Shea C, Broadway-Stringer S, Andaleeb S, Reyat JS, Kabir SN, Stastny D, Malinova A, Delbue D, Fortmueller L, Gehmlich K, Pavlovic D, Skryabin BV, Holmes AP, Kirchhof P, Fabritz L.Europace. 2023 Mar 30;25(3):1152-1161. doi: 10.1093/europace/euac218. PMID: 36504385 Free PMC article.
9.Impaired myocellular Ca2+ cycling in protein phosphatase PP2A-B56α KO mice is normalized by β-adrenergic stimulation.Glaser D, Heinick A, Herting JR, Massing F, Müller FU, Pauls P, Rozhdestvensky TS, Schulte JS, Seidl MD, Skryabin BV, Stümpel F, Kirchhefer U. J Biol Chem. 2022 Sep;298(9):102362. doi: 10.1016/j.jbc.2022.102362. Epub 2022 Aug 10. PMID: 35963431 Free PMC article.
10.Reference Genes across Nine Brain Areas of Wild Type and Prader-Willi Syndrome Mice: Assessing Differences in Igfbp7, Pcsk1, Nhlh2 and Nlgn3 Expression. Kummerfeld DM, Skryabin BV, Brosius J, Vakhrushev SY, Rozhdestvensky TS. Int J Mol Sci. 2022 Aug 5;23(15):8729. doi: 10.3390/ijms23158729. PMID: 35955861 Free PMC article.
11.Rise of cGMP by partial phosphodiesterase-3A degradation enhances cardioprotection during hypoxia.Bork NI, Kuret A, Cruz Santos M, Molina CE, Reiter B, Reichenspurner H, Friebe A, Skryabin BV, Rozhdestvensky TS, Kuhn M, Lukowski R, Nikolaev VO. Redox Biol. 2021 Nov 6;48:102179. doi: 10.1016/j.redox.2021.102179. Online ahead of print. PMID: 34763298
12.Knock-in genome targeting risks: comprehensive analysis is essential for precision chromosome-editing identification.Rozhdestvensky, T. S.; Kummerfeld, D.; Roth, J.;Meuth, S. G.; Pavenstaedt, H.; Sherwood, J.; Pap, T.; Wedlich-Soeldner, R.; Sunderkoetter, C.; Schwartz, Y. B.; Brosius, J.; Skryabin, B. V. FEBS OPEN BIO; Vol 11, p 280-280; Meeting Abstract; P-05.3-04; 2021Jul
13.SNORD116 and growth hormone therapy impact IGFBP7 in Prader-Willi syndrome. Eddiry S, Diene G, Molinas C, Salles J, Auriol FC, Gennero I, Bieth E, Skryabin BV, Rozhdestvensky TS, Burnett LC, Leibel RL, Tauber M, Salles JP. Genet Med. 2021 Sep;23(9):1664-1672. doi: 10.1038/s41436-021-01185-y. Epub 2021 May 26. PMID: 34040195 Free PMC article.
14. Comprehensive Review of Genetically Engineered Mouse Models for Prader-Willi Syndrome Research.Kummerfeld DM, Raabe CA, Brosius J, Mo D, Skryabin BV, Rozhdestvensky TS. AInt J Mol Sci. 2021 Mar 31;22(7):3613. doi: 10.3390/ijms22073613. PMID: 33807162 Free PMC article. Review.
15.TrkC Is Essential for Nephron Function and Trans-Activates Igf1R Signaling. Lepa C, Hoppe S, Stöber A, Skryabin BV, Sievers LK, Heitplatz B, Ciarimboli G, Neugebauer U, Lindenmeyer MT, Cohen CD, Drexler HCA, Boor P, Weide T, Pavenstädt H, George B. J Am Soc Nephrol. 2021 Feb;32(2):357-374. doi: 10.1681/ASN.2020040424. Epub 2020 Dec 30. PMID: 33380522 Free PMC article.
16.Basic DGK and DZHK position paper on genome editing: basic science applications and future perspective. Brandes RP, Dueck A, Engelhardt S, Kaulich M, Kupatt C, De Angelis MT, Leisegang MS, le Noble F, Moretti A, Müller OJ, Skryabin BV, Thum T, Wurst W. Res Cardiol. 2021 Jan 15;116(1):2. doi: 10.1007/s00395-020-00839-3. PMID: 33449167 Free PMC article. Review.
17.TrkC Is Essential for Nephron Function and Trans-Activates Igf1R SignalingGorinski N, Wojciechowski D, Guseva D, Abdel Galil D, Mueller FE, Wirth A, Lepa C, Hoppe S, Stöber A, Skryabin BV, Sievers LK, Heitplatz B, Ciarimboli G, Neugebauer U, Lindenmeyer MT, Cohen CD, Drexler HCA, Boor P, Weide T, Pavenstädt H, George B. J Am Soc Nephrol. 2020 Dec 30:ASN.2020040424. doi:10.1681/ASN.2020040424. Epub ahead of print. PMID: 33380522.
18.C-type natriuretic peptide moderates titin-based cardiomyocyte stiffness. Michel K, Herwig M, Werner F, Špiranec Spes K, Abeßer M, Schuh K, Dabral S, Mügge A, Baba HA, Skryabin BV, Hamdani N, Kuhn M. JCI Insight. 2020 Nov19;5(22):e139910. doi: 10.1172/jci.insight.139910. PMID: 33055420; PMCID:PMC7710274.
19.A paradoxical increase of force development in saphenous and tail arteries from heterozygous ANO1 knockout mice. Matchkov VV, Black Joergensen H, Kamaev D, Hoegh Jensen A, Beck HC, Skryabin BV, Aalkjaer C. Physiol Rep. 2020 Nov;8(22):e14645. doi: 10.14814/phy2.14645. PMID: 33245843; PMCID: PMC7695021.
20.Circular RNA Encoded Amyloid Beta peptides-A Novel Putative Player in Alzheimer's Disease. Mo D, Li X, Raabe CA, Rozhdestvensky TS, Skryabin BV, Brosius J. Cells. 2020 Sep 29;9(10):2196. doi: 10.3390/cells9102196. PMID: 33003364; PMCID:PMC7650678.
21.The Receptor for Advanced Glycation Endproducts (RAGE) Contributes to Severe Inflammatory Liver Injury in Mice. Weinhage T, Wirth T, Schütz P, Becker P, Lueken A, Skryabin BV, Wittkowski H, Foell D. Front Immunol. 2020 Jun 3;11:1157. doi: 10.3389/fimmu.2020.01157. PMID: 32670276; PMCID: PMC7326105.
22.DHHC7-mediated palmitoylation of the accessory protein barttin critically regulates the functions of ClC-K chloride channels. Thiemann S, Zeug A, Schmidt S, Zareba-Kozioł M, Wlodarczyk J, Skryabin BV, Glage S, Fischer M, Al-Samir S, Kerkenberg N, Hohoff C, Zhang W, Endeward V, Ponimaskin E. J Biol Chem. 2020 May 1;295(18):5970-5983. doi: 10.1074/jbc.RA119.011049. Epub 2020 Mar 17. PMID: 32184353; PMCID: PMC7196637.
23.Pervasive head-to-tail insertions of DNA templates mask desired CRISPR-Cas9-mediated genome editing events.Skryabin BV, Kummerfeld DM, Gubar L, Seeger B, Kaiser H, Stegemann A, Roth J, Meuth SG, Pavenstädt H, Sherwood J, Pap T, Wedlich-Söldner R, Sunderkötter C, Schwartz YB, Brosius J, Rozhdestvensky TS. Sci Adv. 2020 Feb 12;6(7):eaax2941. doi: 10.1126/sciadv.aax2941. PMID: 32095517; PMCID: PMC7015686. * (Paper oft the month UKM)
24.DNA barcoding reveals that injected transgenes are predominantly processed by homologous recombination in mouse zygote.Smirnov A, Fishman V, Yunusova A, Korablev A, Serova I, Skryabin BV, Rozhdestvensky TS, Battulin N. Nucleic Acids Res. 2020 Jan 24;48(2):719-735. doi: 10.1093/nar/gkz1085. PMID: 31740957; PMCID: PMC7145541.
25.Time origin and structural analysis of the induced CRISPR/cas9 megabase-sized deletions and duplications involving the Cntn6 gene in mice.Pristyazhnyuk IE, Minina J, Korablev A, Serova I, Fishman V, Gridina M, Rozhdestvensky TS, Gubar L, Skryabin BV, Serov OL. Sci Rep. 2019 Oct 2;9(1):14161. doi: 10.1038/s41598-019-50649-4.
26.A universal approach to investigate circRNA protein coding function. Mo D, Li X, Raabe CA, Cui D, Vollmar JF, Rozhdestvensky TS, Skryabin BV, Brosius J. Sci Rep. 2019 Aug 12;9(1):11684. doi: 10.1038/s41598-019-48224-y.
27.A simple method for in-house Pfu DNA polymerase purification for high-fidelity PCR amplification.Sankar PS, Citartan M, Siti AA, Skryabin BV, Rozhdestvensky TS, Khor GH, Tang TH. Iran J Microbiol. 2019 Apr;11(2):181-186.
28.Deficiency of the palmitoyl acyltransferase ZDHHC7 impacts brain and behavior of mice in a sex-specific manner.Hohoff C, Zhang M, Ambrée O, Kravchenko M, Buschert J, Kerkenberg N, Gorinski N, Abdel Galil D, Schettler C, Vom Werth KL, Wewer MF, Schneider I, Grotegerd D, Wachsmuth L, Faber C, Skryabin BV, Brosius J, Ponimaskin E, Zhang W. Brain Struct Funct. 2019 Jul;224(6):2213-2230. doi: 10.1007/s00429-019-01898-6. Epub 2019 Jun 10.
29.Ectopic expression of Snord115 in choroid plexus interferes with editing but not splicing of 5-Ht2c receptor pre-mRNA in mice.Raabe CA, Voss R, Kummerfeld DM, Brosius J, Galiveti CR, Wolters A, Seggewiss J, Huge A, Skryabin BV, Rozhdestvensky TS. Sci Rep. 2019 Mar 12;9(1):4300. doi: 10.1038/s41598-019-39940-6.
30.A novel isoform of myosin 18A (Myo18Aγ) is an essential sarcomeric protein in mouse heart.Horsthemke M, Nutter LMJ, Bachg AC, Skryabin BV, Honnert U, Zobel T, Bogdan S, Stoll M, Seidl MD, Müller FU, Ravens U, Unger A, Linke WA, van Gorp PRR, de Vries AAF, Bähler M, Hanley PJ. J Biol Chem. 2019 May 3;294(18):7202-7218. doi: 10.1074/jbc.RA118.004560. Epub 2019 Feb 8.
31.BPhenotypic analysis of Myo10 knockout (Myo10tm2/tm2) mice lacking full-length (motorized) but not brain-specific headless myosin X.achg AC, Horsthemke M, Skryabin BV, Klasen T, Nagelmann N, Faber C, Woodham E, Machesky LM, Bachg S, Stange R, Jeong HW, Adams RH, Bähler M, Hanley PJ. Sci Rep. 2019 Jan 24;9(1):597. doi: 10.1038/s41598-018-37160-y.
32.Using CRISPR/Cas9 Nucleases for the production of transgenic mice. Skryabin BV, Rozhdestvensky TS, 2018. in Editing genes and genomes, 2nd edition, RAN, Novosibirsk, Vol. 3, pp 263-281. (Russ)
33.Instrumental method for determining the estrous cycle stages in small laboratory rodents. I.V. Belozertseva, D.D. Merkulovs, O.J. Vilitis, B.V. Skryabin, Laboratory Animals for Science. 2018; Vol. 4, pp 125-135. (Russ)
34.Nephron specific knockin of the PIKfyve binding deficient Vac14L156R mutant results in albuminuria and mesangial expansion.Michgehl U, Skryabin BV, Bayraktar S, Vollenbröker B, Ciarimboli G, Heitplatz B, Van Marck V, Gröne HJ, Pavenstädt H, Weide T. Am J Physiol Renal Physiol. 2018 Aug 1.
35.Homozygous CREM-IbΔC-X Overexpressing Mice Are a Reliable and Effective Disease Model for Atrial Fibrillation.Stümpel FT, Stein J, Himmler K, Scholz B, Seidl MD, Skryabin BV, Müller FU. Front Pharmacol. 2018 Jul 5;9:706.
36.ndothelial C-Type Natriuretic Peptide Acts on Pericytes to Regulate Microcirculatory Flow and Blood Pressure. Špiranec K, Chen W, Werner F, Nikolaev VO, Naruke T, Koch F, Werner A, Eder-Negrin P, Diéguez-Hurtado R, Adams RH, Baba HA, Schmidt H, Schuh K, Skryabin BV, Movahedi K, Schweda F, Kuhn M. ECirculation. 2018 Jul 31;138(5):494-508.
37.Regulation and Function of TMEM16F in Renal Podocytes. Schenk LK, Ousingsawat J, Skryabin BV, Schreiber R,Pavenstädt H, Kunzelmann K. Int J Mol Sci. 2018 Jun 18;19(6).
38.Phenotype analysis of Myo10 knockout mice lacking the motorized full-length, but not the brain-specific headless isoform. Bachg AC, Horsthemke M, Skryabin BV, Klasen T, Nagelmann N, Faber C, Woodham EF, Machesky LM, Bachg, S, Stange R, Jeong, HW, Adams RH, Bahler M, Hanley PJ. FASEB J. 2018 April, Vol 32
39.The LIM-Only Protein Four and a Half LIM Domain Protein 2 Attenuates Development of Psoriatic Arthritis by Blocking Adam17-Mediated Tumor Necrosis Factor Release. Leite Dantas R, Brachvogel B, Schied T, Bergmeier V, Skryabin BV, Vogl T, Ludwig S, Wixler V. Am J Pathol. 2017 Nov;187(11):2388-2398. doi: 10.1016/j.ajpath.2017.07.015.
40.Differential effects of anoctamins on intracellular calcium signals. Cabrita I, Benedetto R, Fonseca A, Wanitchakool P, Sirianant L, Skryabin BV, Schenk LK, Pavenstädt H, Schreiber R, Kunzelmann K. FASEB J. 2017 May;31(5):2123-2134. doi: 10.1096/fj.201600797RR.
41.Eukaryotic elongation factor 2 is a prognostic marker and its kinase a potential therapeutic target in HCC. Pott LL, Hagemann S, Reis H, Lorenz K, Bracht T, Herold T, Skryabin BV, Megger DA, Kälsch J, Weber F, Sitek B, Baba HA. Oncotarget. 2017 Jan 2. doi: 10.18632/oncotarget.14447.
42.BC1 RNA motifs required for dendritic transport in vivo. Robeck T, Skryabin BV, Rozhdestvensky TS, Skryabin AB, Brosius J. Sci Rep. 2016 Jun 28;6:28300. doi: 10.1038/srep28300.
43.Lmbrd1 expression is essential for the initiation of gastrulation. Buers I, Pennekamp P, Nitschke Y, Lowe C, Skryabin BV, Rutsch F. J Cell Mol Med. 2016 Aug;20(8):1523-33. doi: 10.1111/jcmm.12844.
44.Maternal transcription of non-protein coding RNAs from the PWS-critical region rescues growth retardation in mice. Rozhdestvensky T.S.*, Robeck T., Galiveti C.R., Raabe, C.A., Seeger B., Wolters A., Gubar L.V., Skryabin B.V. Sci Rep., 2016 Feb 5;6:20398. doi: 10.1038/srep20398.
45.Neuronal expression of the human neuropeptide S receptor NPSR1 identifies NPS-induced calcium signaling pathways.Erdmann F, Kügler S, Blaesse P, Lange MD, Skryabin BV, Pape HC, Jüngling K. PLoS One. 2015 Feb 25;10(2):e0117319. doi: 10.1371/journal.pone.0117319.
46.FHL2 regulates the resolution of tissue damage in chronic inflammatory arthritis.Wixler V, Cromme C, Retser E, Meyer LH, Smyth N, Mühlenberg K, Korb-Pap A, Koers-Wunrau C, Sotsios Y, Bassel-Duby R, Baeten D, Tak PP, Niederreiter B, Redlich K, Bertrand J, Skryabin BV, Ludwig S, Pap T. Ann Rheum Dis. 2015 Dec;74(12):2216-23. doi: 10.1136/annrheumdis-2013-205061.
47.Anoctamins support calcium-dependent chloride secretion by facilitating calcium signaling in adult mouse intestine. Schreiber R, Faria D, Skryabin BV, Wanitchakool P, Rock JR, Kunzelmann K. Pflugers Arch. 2015 Jun;467(6):1203-13. doi: 10.1007/s00424-014-1559-2.
48.Annexin A8 controls leukocyte recruitment to activated endothelial cells via cell surface delivery of CD63.Poeter M, Brandherm I, Rossaint J, Rosso G, Shahin V, Skryabin BV, Zarbock A, Gerke V, Rescher U. Nat Commun. 2014 Apr 28;5:3738. doi: 10.1038/ncomms4738.
49.Evolutionary and molecular facts link the WWC protein family to Hippo signaling. Wennmann DO, Schmitz J, Wehr MC, Krahn MP, Koschmal N, Gromnitza S, Schulze U, Weide T, Chekuri A, Skryabin BV, Gerke V, Pavenstädt H, Duning K, Kremerskothen J. Mol Biol Evol. 2014 Jul;31(7):1710-23. doi: 10.1093/molbev/msu115.
50.Amodified TALEN-based system for robust generation of knock-out human pluripotent stem cell lines and disease models.Frank S, Skryabin BV, Greber B. BMC Genomics. 2013 Nov 9;14:773. doi: 10.1186/1471-2164-14-773.
51.KIBRA (KIdney/BRAin protein) regulates learning and memory and stabilizes Protein kinase Mζ. Vogt-Eisele A, Krüger C, Duning K, Weber D, Spoelgen R, Pitzer C, Plaas C, Eisenhardt G, Meyer A, Vogt G, Krieger M, Handwerker E, Wennmann DO, Weide T, Skryabin BV, Klugmann M, Pavenstädt H, Huentelmann MJ, Kremerskothen J, Schneider A.J Neurochem. 2014 Mar;128(5):686-700. doi: 10.1111/jnc.12480.
52.Doxycycline-induced expression of transgenic human tumor necrosis factor α in adult mice results in psoriasis-like arthritis.Retser E, Schied T, Skryabin BV, Vogl T, Kanczler JM, Hamann N, Niehoff A, Hermann S, Eisenblätter M, Wachsmuth L, Pap T, van Lent PL, Loser K, Roth J, Zaucke F, Ludwig S, Wixler V. Arthritis Rheum. 2013 Sep;65(9):2290-300. doi: 10.1002/art.38026.
53.Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2. Schmeisser MJ, Ey E, Wegener S, Bockmann J, Stempel AV, Kuebler A, Janssen AL, Udvardi PT, Shiban E, Spilker C, Balschun D, Skryabin BV, Dieck St, Smalla KH, Montag D, Leblond CS, Faure P, Torquet N, Le Sourd AM, Toro R, Grabrucker AM, Shoichet SA, Schmitz D, Kreutz MR, Bourgeron T, Gundelfinger ED, Boeckers TM. Nature. 2012 Apr 29;486(7402):256-60. doi: 10.1038/nature11015.
54.CREMα overexpression decreases IL-2 production, induces a T(H)17 phenotype and accelerates autoimmunity.Lippe R, Ohl K, Varga G, Rauen T, Crispin JC, Juang YT, Kuerten S, Tacke F, Wolf M, Roebrock K, Vogl T, Verjans E, Honke N, Ehrchen J, Foell D, Skryabin B, Wagner N, Tsokos GC, Roth J, Tenbrock K. J Mol Cell Biol. 2012 Apr;4(2):121-3. doi: 10.1093/jmcb/mjs004.